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Cited by 95Virology and Viral DiseasesBacterial Infections and VaccinesVaccine Coverage and Hesitancy

Outbreak of aseptic meningitis associated with mass vaccination with a Urabe-containing measles-mumps-rubella vaccine: implications for immunization programs

Dourado, I., Cunha, S., Teixeira, M. d. G., Farrington, C. P., Melo, A., Lucena, R., Barreto, M. L.·2000·American Journal of Epidemiology
DOI 10.1093/oxfordjournals.aje.a010239
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Abstract

A mass immunization campaign with a Urabe-containing measles-mumps-rubella vaccine was carried out in 1997 in the city of Salvador, northeastern Brazil, with a target population of children aged 1-11 years. There was an outbreak of aseptic meningitis following the mass campaign. Cases of aseptic meningitis were ascertained through data collected from the records of children admitted to the local referral hospital for infectious diseases between March and October of 1997, using previously defined eligibility criteria. Vaccination histories were obtained through home visits or telephone calls. Eighty-seven cases fulfilled the study criteria. Of those, 58 cases were diagnosed after the vaccination campaign. An elevated risk of aseptic meningitis was observed 3 weeks after Brazil's national vaccination day compared with the risk in the prevaccination period (relative risk = 14.3; 95% confidence interval: 7.9, 25.7). This result was confirmed by a case series analysis (relative risk = 30.4; 95% confidence interval: 11.5, 80.8). The estimated risk of aseptic meningitis was 1 in 14,000 doses. This study confirms a link between measles-mumps-rubella vaccination and aseptic meningitis. The authors discuss the implications of this for the organization and planning of mass immunization campaigns.

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Crossref · 10.1093/oxfordjournals.aje.a010239

Cites

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  • In Dourado 2000, the incidence of aseptic meningitis hospitalisation was significantly higher during the fourth week following the start of the immunisation campaign compared with the 23 pre-immunisation weeks (15 cases, RR 11.90; 95% CI 6.38 to 22.19).

    “fourth (15 cases RR 11.90; 95% CI 6.38 to 22.19)”

    From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Dourado 2000

  • In Dourado 2000, the authors attributed 32 of the 37 aseptic meningitis cases with known vaccination status and date occurring during epidemiological weeks 36 to 39 to the Urabe-containing MMR vaccine Pluserix (one in about 14,000 doses).

    “Authors attributed 32 of the 37 cases to be due to Urabe-containing MMR vaccine Pluserix (one in about 14,000 doses).”

    From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Dourado 2000

  • In Dourado 2000, the incidence of aseptic meningitis hospitalisation was significantly higher during the fifth week following the start of the immunisation campaign compared with the 23 pre-immunisation weeks (nine cases, RR 7.14; 95% CI 3.38 to 15.08).

    “fifth (nine cases, RR 7.14; 95% CI 3.38 to 15.08)”

    From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Dourado 2000

  • In Dourado 2000, the incidence of aseptic meningitis hospitalisation was significantly higher during the sixth week following the start of the immunisation campaign compared with the 23 pre-immunisation weeks (four cases, RR 3.17; 95% CI 1.12 to 9.02).

    “sixth (four cases, RR 3.17; 95% CI 1.12 to 9.02)”

    From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Dourado 2000

  • In Dourado 2000, the incidence of aseptic meningitis hospitalisation was significantly higher during the third week following the start of the immunisation campaign compared with the 23 pre-immunisation weeks (18 cases, RR 14.28; 95% CI 7.93 to 25.71).

    “The incidence of aseptic meningitis hospitalisation was significantly higher during the third (18 cases risk ratio (RR) 14.28; 95% CI 7.93 to 25.71)”

    From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Dourado 2000

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Cites

1 retracted

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Research works printed but not linked: 3

  1. Cunha S, Dourado I, Barreto ML, et al. Associac,3o entre meningite asseptica e uso da vacina triplice viral durante a campanha vacinal de 1997. (In Portuguese). Informe Epi- demiol SUS 1998;7:29-61.
  2. Furesz J, Hockin JC. A case of mumps meningitis: a post- immunization complication? Can Dis Wkly Rep 1987;13:155-7.
  3. Morris S. A desigualdade e a saiide publica. [Inequality and public health]. (Editorial). (In Portuguese). Rev Saiide Publica 1997;31:543^.

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Authors
Dourado, I., Cunha, S., Teixeira, M. D. G., Farrington, C. P., Melo, A., Lucena, R., & Barreto, M. L.
Affiliations
Universidade Federal da Bahia (BR)
Corresponding author
Dourado, I.
ORCID
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
2000-03-01
Volume
151
Issue
5
Pages
524-530
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
DOI
10.1093/oxfordjournals.aje.a010239
OpenAlex
W2131566531
Cited by
95
References
30
Citations by year
2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 7 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 6 · 2014: 1 · 2013: 4 · 2012: 5
FWCI
4.81
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
  • Open Research Online (The Open University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
  • Social Sciences › Health › Vaccine Coverage and Hesitancy
Keywords
aseptic meningitis, MMR vaccine, mass vaccination campaigns, vaccine adverse events, immunization program planning, children, Salvador, Bahia
MeSH terms
Brazil, Child, Child, Preschool, Disease Outbreaks, Humans, Infant, Measles Vaccine, Meningitis, Aseptic, Mumps Vaccine, Mumps virus, Product Surveillance, Postmarketing, Retrospective Studies, Risk Factors, Rubella Vaccine, Urban Population, Vaccination, Incidence, Vaccines, Combined, Measles-Mumps-Rubella Vaccine

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