Cited by 101Fatty Acid Research and HealthLipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

LDL cholesterol-raising effect of low-dose docosahexaenoic acid in middle-aged men and women.

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Theobald, Hannah E, Chowienczyk, Philip J, Whittall, Ros, Humphries, Steve E, Sanders, Thomas AB·2004·The American Journal of Clinical Nutrition

Abstract

Background Long-chain n-3 polyunsaturated fatty acids have variable effects on LDL cholesterol, and the effects of docosahexaenoic acid (DHA) are uncertain.Objective The objective of the study was to determine the effect on blood lipids of a daily intake of 0.7 g DHA as triacylglycerol in middle-aged men and women.Design Men and women aged 40-65 y (n = 38) underwent a double-blind, randomized, placebo-controlled, crossover trial of treatment with 0.7 g DHA/d for 3 mo.Results DHA supplementation increased the DHA concentration in plasma by 76% (P < 0.0001) and the proportion in erythrocyte lipids by 58% (P < 0.0001). Values for serum total cholesterol, LDL cholesterol, and plasma apolipoprotein B concentrations were 4.2% (0.22 mmol/L; P = 0.04), 7.1% (0.23 mmol/L; P = 0.004), and 3.4% (P = 0.03) higher, respectively, with DHA treatment than with placebo. In addition, the LDL cholesterol:apolipoprotein B ratio was 3.1% higher with DHA treatment than with placebo (P = 0.04), which suggested an increase in LDL size. Plasma lathosterol and plant sterol concentrations were unaffected by treatment.Conclusion A daily intake of approximately 0.7 g DHA increases LDL cholesterol by 7% in middle-aged men and women. It is suggested that DHA down-regulates the expression of the LDL receptor.

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Crossref · 10.1093/ajcn/79.4.558

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Authors
Theobald, H. E., Chowienczyk, P. J., Whittall, R., Humphries, S. E., & Sanders, T. A.
Affiliations
  • King's College London (GB)
  • St Thomas' Hospital (GB)
Corresponding author
Sanders, Thomas AB
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2004-04
Volume
79
Issue
4
Pages
558-563
ISSN
0002-9165 (ISSN-L)
OpenAlex
W2128858609
Cited by
101
References
33
Citations by year
2025: 2 · 2023: 6 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 7 · 2013: 2 · 2012: 4
FWCI
10.50
Type
journal article
Language
en
Open access
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords
docosahexaenoic acid, LDL cholesterol, omega-3 fatty acids, dietary supplementation, serum lipids, apolipoprotein B, LDL particle size, serum cholesterol, middle-aged adults, erythrocyte fatty acids
MeSH terms
Adult, Aged, Docosahexaenoic Acids, Double-Blind Method, Female, Humans, Lipids, Lipoproteins, Cholesterol, LDL, Male, Middle Aged, Cross-Over Studies

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