Cited by 312Cardiovascular Health and Disease PreventionCardiovascular Function and Risk FactorsBlood Pressure and Hypertension Studies

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Nitroglycerin has more favourable effects on left ventricular afterload than apparent from measurement of pressure in a peripheral artery

KELLY, R. P., GIBS, H. H., O'ROURKE, M. F., DALEY, J. E., MANG, K., MORGEN, J. J., AVOLID, A. P.·1990·European Heart Journal

DOI 10.1093/oxfordjournals.eurheartj.a059669

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Abstract

Nitroglycerin (0.3 mg) was administered sublingually to 14 patients undergoing cardiac catheterization, and pressure waves compared in the ascending aorta and brachial artery. After nitroglycerin, ascending aortic systolic pressure fell in all cases (by 6-44, average 22 mmHg) whereas brachial systolic pressure remained unchanged (in three) or fell to a lesser degree (4-33, average 12 mmHg). Diastolic pressure did not change significantly. Alterations in pressure and in wave contour were explained on the basis of arterial dilation, with reduction in wave reflection. Nitroglycerin reduces left ventricular afterload through arterial dilation as well as preload through venous dilation. This effect on afterload is not apparent from measurement of pressure in the brachial artery.

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Authors: KELLY, R. P., GIBS, H. H., O'ROURKE, M. F., DALEY, J. E., MANG, K., MORGEN, J. J., & AVOLID, A. P.
Affiliations: UNSW Sydney (AU)
ORCID: KELLY, R. P.
Venue: European Heart Journal
Publisher: Oxford University Press (OUP)
Published: 1990-02
Volume: 11
Issue: 2
Pages: 138-144
ISSN: 0195-668X (ISSN-L)
1522-9645
DOI: 10.1093/oxfordjournals.eurheartj.a059669
OpenAlex: W1927450934
Cited by: 312
References: 0
Citations by year: 2026: 2 · 2025: 5 · 2024: 4 · 2023: 4 · 2022: 9 · 2021: 8 · 2020: 9 · 2019: 10 · 2018: 7 · 2017: 11 · 2016: 15 · 2015: 5 · 2014: 17 · 2013: 10 · 2012: 16
FWCI: 5.58
Type: journal article
Language: en
Open access: closed
Locations: European Heart Journal (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords: nitroglycerin, left ventricular afterload, arterial dilatation, wave reflection, aortic pressure, sublingual administration, venous dilation, preload
MeSH terms: Administration, Sublingual, Adult, Aged, Aorta, Blood Pressure, Blood Pressure Determination, Female, Nitroglycerin, Cardiac Catheterization, Heart Ventricles, Humans, Male, Middle Aged, Vasodilation

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Nitroglycerin has more favourable effects on left ventricular afterload than apparent from measurement of pressure in a peripheral artery

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