The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.
Midkine and Pleiotrophin: Two Related Proteins Involved in Development, Survival, Inflammation and Tumorigenesis
Abstract
Midkine (MK) and pleiotrophin (PTN) are low molecular weight proteins with closely related structures. They are mainly composed of two domains held by disulfide bridges, and there are three antiparallel beta-sheets in each domain. MK and PTN promote the growth, survival, and migration of various cells, and play roles in neurogenesis and epithelial mesenchymal interactions during organogenesis. A chondroitin sulfate proteoglycan, protein-tyrosine phosphatase zeta (PTPzeta), is a receptor for MK and PTN. The downstream signaling system includes ERK and PI3 kinase. MK binds to the chondroitin sulfate portion of PTPzeta with high affinity. Among the various chondroitin sulfate structures, the E unit, which has 4,6-disulfated N-acetylgalactosamine, provides the strongest binding site. The expression of MK and PTN is increased in various human tumors, making them promising as tumor markers and as targets for tumor therapy. MK and PTN expression also increases upon ischemic injury. MK enhances the migration of inflammatory cells, and is involved in neointima formation and renal injury following ischemia. MK is also interesting from the viewpoints of the treatment of neurodegenerative diseases, increasing the efficiency of in vitro development, and the prevention of HIV infection.
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arrow encodes an LDL-receptor-related protein essential for Wingless signalling
Wehrli, M., Dougan, S. T., Caldwell, K., O'Keefe, L., Schwartz, S., Vaizel-Ohayon, D., Schejter, E., Tomlinson, A., & DiNardo, S. (2000) · Nature · doi:10.1038/35035110 · Cited by 871
Kadomatsu, K., Tomomura, M., & Muramatsu, T. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80505-9 · Cited by 486
Self-citationLi, Y.-S., Milner, P. G., Chauhan, A. K., Watson, M. A., Hoffman, R. M., Kodner, C. M., Milbrandt, J., & Deuel, T. F. (1990) · Science · doi:10.1126/science.2270483 · Cited by 474
Meng, K., Rodríguez-Peña, A., Dimitrov, T., Chen, W., Yamin, M., Noda, M., & Deuel, T. F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.020487997 · Cited by 418
Reelin-induced tryosine phosphorylation of Disabled 1 during neuronal positioning
Howell, B. W., Herrick, T. M., & Cooper, J. A. (1999) · Genes & Development · doi:10.1101/gad.13.6.643 · Cited by 411
Identification of Anaplastic Lymphoma Kinase as a Receptor for the Growth Factor Pleiotrophin
Stoica, G. E., Kuo, A., Aigner, A., Sunitha, I., Souttou, B., Malerczyk, C., Caughey, D. J., Wen, D., Karavanov, A., Riegel, A. T., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010660200 · Cited by 382
Rauvala, H. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08443.x · Cited by 372
Maeda, N., Ichihara-Tanaka, K., Kimura, T., Kadomatsu, K., Muramatsu, T., & Noda, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.18.12474 · Cited by 315
Self-citationMitsiadis, T. A., Salmivirta, M., Muramatsu, T., Muramatsu, H., Rauvala, H., Lehtonen, E., Jalkanen, M., & Thesleff, I. (1995) · Development · doi:10.1242/dev.121.1.37 · Cited by 292
Self-citationRaulo, E., Chernousov, M. A., Carey, D. J., Nolo, R., & Rauvala, H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99975-8 · Cited by 284
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Metadata
- Authors
- Muramatsu, T.
- Venue
- Journal of Biochemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-09-01
- Volume
- 132
- Issue
- 3
- Pages
- 359-371
- ISSN
- 0021-924X (ISSN-L)
- OpenAlex
- W2074274229
- Cited by
- 405
- References
- 113
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Midkine and Pleiotrophin: Two Related Proteins Involved in Development, Survival, Inflammation and Tumorigenesis. https://app.cochat.ai/papers/10.1093/oxfordjournals.jbchem.a003231
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- Muramatsu, T. (2002). Midkine and Pleiotrophin: Two Related Proteins Involved in Development, Survival, Inflammation and Tumorigenesis. Journal of Biochemistry. https://doi.org/10.1093/oxfordjournals.jbchem.a003231
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