Cited by 411Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Reelin-induced tryosine phosphorylation of Disabled 1 during neuronal positioning

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Howell, B. W., Herrick, T. M., Cooper, J. A.·1999·Genes & Development

Abstract

The reelin (reln) and disabled 1 (dab1) genes both ensure correct neuronal positioning during brain development. We have found that the intracellular Dab1 protein receives a tyrosine phosphorylation signal from extracellular Reln protein. Genetic analysis shows that reln function depends on dab1, and vice versa, as expected if both genes are in the same pathway. Dab1 is expressed at a higher level, yet phosphorylated at a lower level, in reln mutant embryo brains. In primary neuronal cultures, Dab1 tyrosine phosphorylation is stimulated by exogenous Reln. These results suggest that Reln regulates neuronal positioning by stimulating Dab1 tyrosine phosphorylation.

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Authors
Howell, B. W., Herrick, T. M., & Cooper, J. A.
Affiliations
Fred Hutch Cancer Center (US)
Venue
Genes & Development
Published
1999-03-15
Volume
13
Issue
6
Pages
643-648
ISSN
0890-9369 (ISSN-L)
OpenAlex
W2162321314
Cited by
411
References
40
Citations by year
2026: 2 · 2025: 6 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 14 · 2020: 8 · 2019: 6 · 2018: 8 · 2017: 19 · 2016: 13 · 2015: 10 · 2014: 14 · 2013: 13 · 2012: 10
Type
posted content
Language
en
Open access
Locations
  • Genes & Development (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (R37CA041072, CA41072, R01CA041072)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
reelin, Disabled-1, Dab1, tyrosine phosphorylation, neuronal positioning, brain development, extracellular signaling, primary neuronal cultures, signaling pathways
MeSH terms
Reelin Protein, Animals, Heterozygote, Mutation, Nerve Tissue Proteins, Neurons, Phosphoproteins, Phosphorylation, Serine Endopeptidases, Tyrosine, Signal Transduction, Cell Adhesion Molecules, Neuronal, Gene Expression, Extracellular Matrix Proteins, Mice

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