Reelin-induced tryosine phosphorylation of Disabled 1 during neuronal positioning
Open accessAbstract
The reelin (reln) and disabled 1 (dab1) genes both ensure correct neuronal positioning during brain development. We have found that the intracellular Dab1 protein receives a tyrosine phosphorylation signal from extracellular Reln protein. Genetic analysis shows that reln function depends on dab1, and vice versa, as expected if both genes are in the same pathway. Dab1 is expressed at a higher level, yet phosphorylated at a lower level, in reln mutant embryo brains. In primary neuronal cultures, Dab1 tyrosine phosphorylation is stimulated by exogenous Reln. These results suggest that Reln regulates neuronal positioning by stimulating Dab1 tyrosine phosphorylation.
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Reelin induces tyrosine phosphorylation of Dab1.
“Reelin induces tyrosine phosphorylation of Dab1 (24).”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [24]
Dab1 phosphorylation is essential in Reelin signaling.
“Because the Dab1 phosphorylation is essential in Reelin signaling (24, 35–37)”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [24]
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- Authors
- Howell, B. W., Herrick, T. M., & Cooper, J. A.
- Affiliations
- Fred Hutch Cancer Center (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-03-15
- Volume
- 13
- Issue
- 6
- Pages
- 643-648
- ISSN
- 0890-9369 (ISSN-L)
- PMC
- PMC316552
- OpenAlex
- W2162321314
- Cited by
- 411
- References
- 40
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 14 · 2020: 8 · 2019: 6 · 2018: 8 · 2017: 19 · 2016: 13 · 2015: 10 · 2014: 14 · 2013: 13 · 2012: 10
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R37CA041072, CA41072, R01CA041072)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- reelin, Disabled-1, Dab1, tyrosine phosphorylation, neuronal positioning, brain development, extracellular signaling, primary neuronal cultures, signaling pathways
- MeSH terms
- Reelin Protein, Animals, Heterozygote, Mutation, Nerve Tissue Proteins, Neurons, Phosphoproteins, Phosphorylation, Serine Endopeptidases, Tyrosine, Signal Transduction, Cell Adhesion Molecules, Neuronal, Gene Expression, Extracellular Matrix Proteins, Mice
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