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Hierarchical patterns of global human Y-chromosome diversity.

Hammer, Michael F., Karafet, Tatiana M., Redd, Alan J., Jarjanazi, Hamdi, Santachiara-Benerecetti, Silvana, Soodyall, Himla, Zegura, Stephen L.·2001·Molecular Biology and Evolution
DOI 10.1093/oxfordjournals.molbev.a003906
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Abstract

We examined 43 biallelic polymorphisms on the nonrecombining portion of the Y chromosome (NRY) in 50 human populations encompassing a total of 2,858 males to study the geographic structure of Y-chromosome variation. Patterns of NRY diversity varied according to geographic region and method/level of comparison. For example, populations from Central Asia had the highest levels of heterozygosity, while African populations exhibited a higher level of mean pairwise differences among haplotypes. At the global level, 36% of the total variance of NRY haplotypes was attributable to differences among populations (i.e., Phi(ST) = 0.36). When a series of AMOVA analyses was performed on different groupings of the 50 populations, high levels of among-groups variance (Phi(CT)) were found between Africans, Native Americans, and a single group containing all 36 remaining populations. The same three population groupings formed distinct clusters in multidimensional scaling plots. A nested cladistic analysis (NCA) demonstrated that both population structure processes (recurrent gene flow restricted by isolation by distance and long-distance dispersals) and population history events (contiguous range expansions and long-distance colonizations) were instrumental in explaining this tripartite division of global NRY diversity. As in our previous analyses of smaller NRY data sets, the NCA detected a global contiguous range expansion out of Africa at the level of the total cladogram. Our new results s…

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Cited by

Metadata

Authors
Hammer, M. F., Karafet, T. M., Redd, A. J., Jarjanazi, H., Santachiara-Benerecetti, S., Soodyall, H., & Zegura, S. L.
Venue
Molecular Biology and Evolution
Publisher
Oxford University Press (OUP)
Published
2001-07-01
Volume
18
Issue
7
Pages
1189-1203
ISSN
  • 1537-1719
  • 0737-4038
DOI
10.1093/oxfordjournals.molbev.a003906
Cited by
192
References
0
Language
en

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