Paired sequence difference in ribosomal RNAs: evolutionary and phylogenetic implications.
Open accessAbstract
Ribosomal RNAs have secondary structures that are maintained by internal Watson-Crick pairing. Through analysis of chordate, arthropod, and plant 5S ribosomal RNA sequences, we show that Darwinian selection operates on these nucleotide sequences to maintain functionally important secondary structure. Insect phylogenies based on nucleotide positions involved in pairing and the production of secondary structure are incongruent with those constructed on the basis of positions that are not. Furthermore, phylogeny reconstruction using these nonpairing bases is concordant with other, morphological data.
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rDNA stem nucleotide positions covary because natural selection tends to maintain secondary Watson-Crick base-pairing structure in the functional rRNA.
“Wheeler and Honeycutt ( 1988) noted that rDNA stem nucleotide positions covary because natural selection tends to maintain secondary Watson-Crick base-pairing structure in the functional rRNA.”
From Phylogeny of the Bovidae (Artiodactyla, Mammalia), based on mitochondrial ribosomal DNA sequences. (1992) · cites this paper as Wheeler and Honeycutt 1988
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- Authors
- Wheeler, W. C., & Honeycutt, R. L.
- Affiliations
- Harvard University (US)
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 1988-01
- Volume
- 5
- Issue
- 1
- Pages
- 90-6
- ISSN
- 0737-4038 (ISSN-L)
- 1537-1719
- OpenAlex
- W1918720391
- Cited by
- 234
- References
- 12
- Citations by year
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- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Biology and Evolution (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Keywords
- ribosomal RNA, 5S rRNA, Watson-Crick base pairing, secondary structure, phylogenetic incongruence, insect phylogeny, Chordata, arthropods, plants, nucleotide selection, phylogenetic inference
- MeSH terms
- Animals, Base Sequence, Biological Evolution, Invertebrates, Models, Genetic, Nucleic Acid Conformation, Phylogeny, Plants, RNA, Ribosomal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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