Cited by 234RNA and protein synthesis mechanismsGenomics and Phylogenetic StudiesChromosomal and Genetic Variations

Paired sequence difference in ribosomal RNAs: evolutionary and phylogenetic implications.

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Ward C. Wheeler, Rodney L. Honeycutt·1988·Molecular Biology and Evolution

Abstract

Ribosomal RNAs have secondary structures that are maintained by internal Watson-Crick pairing. Through analysis of chordate, arthropod, and plant 5S ribosomal RNA sequences, we show that Darwinian selection operates on these nucleotide sequences to maintain functionally important secondary structure. Insect phylogenies based on nucleotide positions involved in pairing and the production of secondary structure are incongruent with those constructed on the basis of positions that are not. Furthermore, phylogeny reconstruction using these nonpairing bases is concordant with other, morphological data.

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Crossref · 10.1093/oxfordjournals.molbev.a040480

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  • rDNA stem nucleotide positions covary because natural selection tends to maintain secondary Watson-Crick base-pairing structure in the functional rRNA.

    “Wheeler and Honeycutt ( 1988) noted that rDNA stem nucleotide positions covary because natural selection tends to maintain secondary Watson-Crick base-pairing structure in the functional rRNA.”

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Authors
Wheeler, W. C., & Honeycutt, R. L.
Affiliations
Harvard University (US)
Venue
Molecular Biology and Evolution
Published
1988-01
Volume
5
Issue
1
Pages
90-6
ISSN
  • 0737-4038 (ISSN-L)
  • 1537-1719
OpenAlex
W1918720391
Cited by
234
References
12
Citations by year
2025: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 1 · 2012: 3
FWCI
2.90
Type
journal article
Language
en
Open access
Locations
  • Molecular Biology and Evolution (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Science Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
Keywords
ribosomal RNA, 5S rRNA, Watson-Crick base pairing, secondary structure, phylogenetic incongruence, insect phylogeny, Chordata, arthropods, plants, nucleotide selection, phylogenetic inference
MeSH terms
Animals, Base Sequence, Biological Evolution, Invertebrates, Models, Genetic, Nucleic Acid Conformation, Phylogeny, Plants, RNA, Ribosomal

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