The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
Molecular Basis of the Core Regulatory Network in ABA Responses: Sensing, Signaling and Transport
Open accessAbstract
ABA is a major phytohormone that regulates a broad range of plant traits and is especially important for adaptation to environmental conditions. Our understanding of the molecular basis of ABA responses in plants improved dramatically in 2009 and 2010, banner years for ABA research. There are three major components; PYR/PYL/ RCAR (an ABA receptor), type 2C protein phosphatase (PP2C; a negative regulator) and SNF1-related protein kinase 2 (SnRK2; a positive regulator), and they offer a double negative regulatory system, [PYR/PYL/RCAR-| PP2C-| SnRK2]. In the absence of ABA, PP2C inactivates SnRK2 by direct dephosphorylation. In response to environmental or developmental cues, ABA promotes the interaction of PYR/PYL/RCAR and PP2C, resulting in PP2C inhibition and SnRK2 activation. This signaling complex can work in both the nucleus and cytosol, as it has been shown that SnRK2 phosphorylates basic-domain leucine zipper (bZIP) transcription factors or membrane proteins. Several structural analyses of PYR/PYL/RCAR have provided the mechanistic basis for this 'core signaling' model, by elucidating the mechanism of ABA binding of receptors, or the 'gate-latch-lock' mechanism of interaction with PP2C in inhibiting activity. On the other hand, intercellular ABA transport had remained a major issue, as had intracellular ABA signaling. Recently, two plasma membrane-type ABC transporters were identified and shed light on the influx/efflux system of ABA, resolving how ABA is transported from cell to cell in plants. Our knowledge of ABA responses in plants has been greatly expanded from intracellular signaling to intercellular transport of ABA.
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Citations
Cites
MYB transcription factors in Arabidopsis
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ABC Transporters: From Microorganisms to Man
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Abscisic Acid: Emergence of a Core Signaling Network
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Abscisic Acid Inhibits Type 2C Protein Phosphatases via the PYR/PYL Family of START Proteins
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Regulators of PP2C Phosphatase Activity Function as Abscisic Acid Sensors
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ABSCISIC ACID BIOSYNTHESIS AND CATABOLISM
Nambara, E., & Marion-Poll, A. (2005) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.56.032604.144046 · Cited by 2,237
The Physcomitrella Genome Reveals Evolutionary Insights into the Conquest of Land by Plants
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bZIP transcription factors in Arabidopsis
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Mechanism of auxin perception by the TIR1 ubiquitin ligase
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Cited by
Effects of abiotic stress on plants: a systems biology perspective
Cramer, G. R., Urano, K., Delrot, S., Pezzotti, M., & Shinozaki, K. (2011) · BMC Plant Biology · doi:10.1186/1471-2229-11-163 · Cited by 1,375
Self-citationNakashima, K., Yamaguchi-Shinozaki, K., & Shinozaki, K. (2014) · Frontiers in Plant Science · doi:10.3389/fpls.2014.00170 · Cited by 891
Self-citationABA signaling in stress-response and seed development
Nakashima, K., & Yamaguchi-Shinozaki, K. (2013) · Plant Cell Reports · doi:10.1007/s00299-013-1418-1 · Cited by 852
Self-citationWRKY transcription factors: key components in abscisic acid signalling
Rushton, D. L., Tripathi, P., Rabara, R. C., Lin, J., Ringler, P., Boken, A. K., Langum, T. J., Smidt, L., Boomsma, D. D., Emme, N. J., et al. (2012) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2011.00634.x · Cited by 638
Gonzalez-Guzman, M., Pizzio, G. A., Antoni, R., Vera-Sirera, F., Merilo, E., Bassel, G. W., Fernández, M. A., Holdsworth, M. J., Perez-Amador, M. A., Kollist, H., et al. (2012) · The Plant Cell · doi:10.1105/tpc.112.098574 · Cited by 579
Metadata
- Authors
- Umezawa, T., Nakashima, K., Miyakawa, T., Kuromori, T., Tanokura, M., Shinozaki, K., & Yamaguchi-Shinozaki, K.
- Venue
- Plant and Cell Physiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-10-26
- Volume
- 51
- Issue
- 11
- Pages
- 1821-1839
- ISSN
- 0032-0781 (ISSN-L)
- 1471-9053
- OpenAlex
- W2147124511
- Cited by
- 929
- References
- 109
- FWCI
- 47.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Umezawa, T., Nakashima, K., Miyakawa, T., Kuromori, T., Tanokura, M., Shinozaki, K., & Yamaguchi-Shinozaki, K. (2010). Molecular Basis of the Core Regulatory Network in ABA Responses: Sensing, Signaling and Transport. Plant and Cell Physiology. https://doi.org/10.1093/pcp/pcq156
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