Advances in functionalized polymer coatings on biodegradable magnesium alloys–A review
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Magnesium (Mg) and its alloys have become a research frontier in biodegradable materials owing to their superior biocompatibility and excellent biomechanical compatibility. However, their high degradation rate in the physiological environment should be well tackled prior to clinical applications. This review summarizes the latest progress in the development of polymeric coatings on biodegradable Mg alloys over the last decade, regarding preparation strategies for polylactic acid (PLA), poly (latic-co-glycolic) acid (PLGA), polycaprolactone (PCL), polydopamine (PDA), chitosan (CS), collagen (Col) and their composite, and their performance in terms of corrosion resistance and biocompatibility. Feasible perspectives and developing directions of next generation of polymeric coatings with respect to biomedical Mg alloys are briefly discussed.Statement of significance Magnesium (Mg) and its alloys have become a research frontier in biodegradable materials owing to their superior biocompatibility and suitable biomechanical compatibility. However, the principal drawback of Mg-based implants is their poor corrosion resistance in physiological environments. Hence, it is vital to mitigate the degradation/corrosion behavior of Mg alloys for safe biomedical deployments. This review summarizes the latest progress in development of polymeric coatings on biomedical Mg alloys regarding preparation strategy, corrosion resistance and biocompatibility, including polylactic acid (PLA), poly (latic-co-glycolic) acid (PLGA), polycaprolactone (PCL), chitosan (CS), polydopamine (PDA), collagen (Col) and their composite. In addition, functionalized polymer coatings with Mg alloys exhibits a promising prospect owing to their ability of degradation along with biocompatibility, self-healing, drug-delivery and osteoinduction.
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Natural polymer-based coatings have been actively investigated to simultaneously achieve degradation control and enhanced cell affinity for magnesium implants.
“Natural polymer-based coatings have been actively investigated to simultaneously achieve degradation control and enhanced cell affinity for magnesium implants [1].”
From Functional Surface Modification of Magnesium Implant by Drug-Loaded Biodegradable Polymer Coating (2026) · cites this paper as [1]
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Zou, Y.-H., Wang, J., Cui, L.-Y., Zeng, R.-C., Wang, Q.-Z., Han, Q.-X., Qiu, J., Chen, X.-B., Chen, D.-C., Guan, S.-K., et al. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.05.069 · Cited by 173 · see citing works
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Self-citationFunctional Surface Modification of Magnesium Implant by Drug-Loaded Biodegradable Polymer Coating
Park, J.-E., Jang, Y.-S., Ko, S.-O., & Lee, M.-H. (2026) · Applied Sciences · doi:10.3390/app16031542 · Cited by 2 · see citing works
- Authors
- Li, L.-Y., Cui, L.-Y., Zeng, R.-C., Li, S.-Q., Chen, X.-B., Zheng, Y., & Kannan, M. B.
- Affiliations
- Shandong University of Science and Technology (CN)
- Peking University (CN)
- James Cook University (AU)
- Corresponding author
- Zeng, Rong-Chang
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 79
- Pages
- 23-36
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W2888057232
- Cited by
- 466
- References
- 133
- Citations by year
- 2026: 26 · 2025: 50 · 2024: 59 · 2023: 59 · 2022: 69 · 2021: 70 · 2020: 81 · 2019: 46 · 2018: 6
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Acta Biomaterialia (publishedVersion)
- PubMed (publishedVersion)
- ResearchOnline - JCU (James Cook University) (submittedVersion)
- RMIT Research Repository (RMIT University Library) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- National Natural Science Foundation of China (51571134)
- Shandong University of Science and Technology (2014TDJH104)
- Science and Technology Innovation Fund of SDUST (SDKDYC180371)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Materials Science › Materials Chemistry › Titanium Alloys Microstructure and Properties
- Keywords
- biodegradable magnesium alloys, polymer coatings, corrosion resistance, biocompatibility, polylactic acid, PLGA, polycaprolactone, polydopamine, chitosan, collagen, composite coatings, magnesium implants, degradation rate, self-healing coatings, drug delivery, osteoinduction
- MeSH terms
- Alloys, Corrosion, Humans, Magnesium, Polymers, Coated Materials, Biocompatible
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