Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

Neutrophil Extracellular Traps Kill Bacteria

Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268 · see citing works

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107000-00002 · Cited by 8,503 · see citing works

The epidemiology of sepsis in the United States from 1979 through 2000

Martin, G. S., Mannino, D. M., Eaton, S., & Moss, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022139 · Cited by 5,841 · see citing works

Novel cell death program leads to neutrophil extracellular traps

Fuchs, T. A., Abed, U., Goosmann, C., Hurwitz, R., Schulze, I., Wahn, V., Weinrauch, Y., Brinkmann, V., & Zychlinsky, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200606027 · Cited by 3,197 · see citing works

Extracellular DNA traps promote thrombosis

Fuchs, T. A., Brill, A. G., Duerschmied, D., Schatzberg, D., Monestier, M., Myers, D. D., Wrobleski, S. K., Wakefield, T. W., Hartwig, J. H., & Wagner, D. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005743107 · Cited by 2,517 · see citing works

Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood

Clark, S. R., Ma, A. C., Tavener, S. A., McDonald, B., Goodarzi, Z., Kelly, M. M., Patel, K. D., Chakrabarti, S., McAvoy, E., Sinclair, G. D., et al. (2007) · Nature Medicine · doi:10.1038/nm1565 · Cited by 2,309 · see citing works

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

Papayannopoulos, V., Metzler, K. D., Hakkim, A., & Zychlinsky, A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201006052 · Cited by 2,103 · see citing works

HOW NEUTROPHILS KILL MICROBES

Segal, A. W. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115653 · Cited by 1,783 · see citing works

Netting neutrophils in autoimmune small-vessel vasculitis

Kessenbrock, K., Krumbholz, M., Schönermarck, U., Back, W. E., Gross, W. L., Werb, Z., Gröne, H., Brinkmann, V., & Jenne, D. E. (2009) · Nature Medicine · doi:10.1038/nm.1959 · Cited by 1,650 · see citing works

Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus

Diep, B. A., Gill, S. R., Chang, R. F., Phan, T. H., Chen, J. H., Davidson, M. G., Lin, F., Lin, J., Carleton, H. A., Mongodin, E. F., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68231-7 · Cited by 1,633 · see citing works

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

Wang, Y., Li, M., Stadler, S. C., Correll, S., Li, P., Wang, D., Hayama, R., Leonelli, L., Han, H., Grigoryev, S. A., et al. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200806072 · Cited by 1,532 · see citing works

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

Li, P., Li, M., Lindberg, M. R., Kennett, M. J., Xiong, N., & Wang, Y. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100239 · Cited by 1,495 · see citing works

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

Hakkim, A., Fürnrohr, B. G., Amann, K., Laube, B., Abed, U. A., Brinkmann, V., i, M. H., Voll, R. E., & Zychlinsky, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909927107 · Cited by 1,473 · see citing works

A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to <i>Staphylococcus aureus</i>

Pilsczek, F. H., Salina, D., Poon, K. K. H., Fahey, C., Yipp, B. G., Sibley, C. D., Robbins, S. M., Green, F. H. Y., Surette, M. G., Sugai, M., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000675 · Cited by 1,114 · see citing works

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

Yousefi, S., Mihalache, C., Kozlowski, E., Schmid, I., & Simon, H. U. (2009) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2009.96 · Cited by 1,036 · see citing works

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

Yousefi, S., Gold, J. A., Andina, N., Lee, J. J., Kelly, A. M., Kozlowski, E., Schmid, I., Straumann, A., Reichenbach, J., Gleich, G. J., et al. (2008) · Nature Medicine · doi:10.1038/nm.1855 · Cited by 967 · see citing works

Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

Flannagan, R. S., Cosío, G., & Grinstein, S. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2128 · Cited by 947 · see citing works

Beneficial suicide: why neutrophils die to make NETs

Brinkmann, V., & Zychlinsky, A. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1710 · Cited by 937 · see citing works

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

Hakkim, A., Fuchs, T. A., Martinez, N. E., Hess, S., Prinz, H., Zychlinsky, A., & Waldmann, H. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.496 · Cited by 793 · see citing works

How human neutrophils kill and degrade microbes: an integrated view

Nauseef, W. M. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00550.x · Cited by 756 · see citing works

DNase Expression Allows the Pathogen Group A Streptococcus to Escape Killing in Neutrophil Extracellular Traps

Buchanan, J. T., Simpson, A. J., Aziz, R. K., Liu, G. Y., Kristian, S. A., Kotb, M., Feramisco, J. R., & Nizet, V. (2006) · Current Biology · doi:10.1016/j.cub.2005.12.039 · Cited by 683 · see citing works

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

Remijsen, Q., Kuijpers, T. W., Wirawan, E., Lippens, S., Vandenabeele, P., & Berghe, T. V. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.1 · Cited by 612 · see citing works

Nuclear mechanics during cell migration

Friedl, P., Wolf, K., & Lammerding, J. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.10.015 · Cited by 511 · see citing works

Nuclease Expression by Staphylococcus aureus Facilitates Escape from Neutrophil Extracellular Traps

Berends, E. T. M., Horswill, A. R., Haste, N. M., Monestier, M., Nizet, V., & von Köckritz‐Blickwede, M. (2010) · Journal of Innate Immunity · doi:10.1159/000319909 · Cited by 492 · see citing works

Phagocytosis by neutrophils

Lee, W. L., Harrison, R. E., & Grinstein, S. (2003) · Microbes and Infection · doi:10.1016/j.micinf.2003.09.014 · Cited by 433 · see citing works

DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection

Walker, M. J., Hollands, A., Sanderson‐Smith, M. L., Cole, J. N., Kirk, J. K., Henningham, A., McArthur, J. D., Dinkla, K., Aziz, R. K., Kansal, R. G., et al. (2007) · Nature Medicine · doi:10.1038/nm1612 · Cited by 427 · see citing works

Molecular insight into invasive group A streptococcal disease

Cole, J. N., Barnett, T. C., Nizet, V., & Walker, M. J. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2648 · Cited by 375 · see citing works

Extracellular deoxyribonuclease made by group A Streptococcus assists pathogenesis by enhancing evasion of the innate immune response

Sumby, P., Barbian, K., Gardner, D. J., Whitney, A. R., Welty, D. M., Long, R. D., Bailey, J. R., Parnell, M. J., Hoe, N. P., Adams, G. G., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406641102 · Cited by 341 · see citing works

Gene replacement in Staphylococcus carnosus and Staphylococcus xylosus

Brückner, R. (2006) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1997.tb10387.x · Cited by 295 · see citing works

Crosstalk pathways between Toll-like receptors and the complement system

Hajishengallis, G., & Lambris, J. D. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.01.002 · Cited by 276 · see citing works

Gene replacement in Staphylococcus carnosus and Staphylococcus xylosus

Brückner, R. (1997) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(97)00116-x · Cited by 254 · see citing works

A Role for Platelets and Endothelial Selectins in Tumor Necrosis Factor-α–Induced Leukocyte Recruitment in the Brain Microvasculature

Tavares, J. C., Hickey, M. J., Hutchison, J. S., Michaud, J., Sutcliffe, I. T., & Kubes, P. (2000) · Circulation Research · doi:10.1161/01.res.87.12.1141 · Cited by 236 · see citing works

Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases and mDia2

Ji, P., Jayapal, S. R., & Lodish, H. F. (2008) · Nature Cell Biology · doi:10.1038/ncb1693 · Cited by 234 · see citing works

Neutrophil Extracellular Trap (NET)-Mediated Killing of Pseudomonas aeruginosa: Evidence of Acquired Resistance within the CF Airway, Independent of CFTR

Young, R. L., Malcolm, K. C., Kret, J. E., Caceres, S. M., Poch, K. R., Nichols, D. P., Taylor‐Cousar, J. L., Saavedra, M. T., Randell, S. H., Vasil, M. L., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023637 · Cited by 226 · see citing works

Ultrastructural characterization of cystic fibrosis sputum using atomic force and scanning electron microscopy

Manzenreiter, R., Kienberger, F., Marcos, V., Schilcher, K., Krautgartner, W. D., Obermayer, A., Huml, M., Stoiber, W., Hector, A., Griese, M., et al. (2011) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2011.09.008 · Cited by 200 · see citing works

Formation of mammalian erythrocytes: chromatin condensation and enucleation

Ji, P., Murata‐Hori, M., & Lodish, H. F. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.04.003 · Cited by 188 · see citing works

Evidence for reactive nitrogen intermediates in killing of staphylococci by human neutrophil cytoplasts. A new microbicidal pathway for polymorphonuclear leukocytes.

Malawista, S. E., Montgomery, R. R., & Blaricom, G. V. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115903 · Cited by 184 · see citing works

Visualization of Plasmodium falciparum– Endothelium Interactions in Human Microvasculature

Ho, M., Hickey, M. J., Murray, A. G., Andonegui, G., & Kubes, P. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.8.1205 · Cited by 109 · see citing works

The cytokineplast: purified, stable, and functional motile machinery from human blood polymorphonuclear leukocytes

Malawista, S. E., & Chevance, A. D. B. (1982) · The Journal of Cell Biology · doi:10.1083/jcb.95.3.960 · Cited by 102 · see citing works

Construction and Application of Epitope- and Green Fluorescent Protein-Tagging Integration Vectors for Bacillus subtilis

Kaltwasser, M., Wiegert, T., & Schumann, W. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.5.2624-2628.2002 · Cited by 98 · see citing works

Glutathione Reductase Facilitates Host Defense by Sustaining Phagocytic Oxidative Burst and Promoting the Development of Neutrophil Extracellular Traps

Yan, J., Meng, X., Wancket, L. M., Lintner, K. E., Nelin, L. D., Chen, B., Francis, K. P., Smith, C. V., Rogers, L. K., & Liu, Y. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102683 · Cited by 80 · see citing works

Methicillin-resistant Staphylococcus aureus: a new community-acquired pathogen?

Kollef, M. H., & Micek, S. T. (2006) · Current Opinion in Infectious Diseases · doi:10.1097/01.qco.0000216627.13445.e2 · Cited by 79 · see citing works

Neutrophil extracellular traps

Amulic, B., & Hayes, G. L. (2011) · Current Biology · doi:10.1016/j.cub.2011.03.021 · Cited by 74 · see citing works

In the middle of it all: Mutual mechanical regulation between the nucleus and the cytoskeleton

Dahl, K. N., Booth-Gauthier, E. A., & Ladoux, B. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.09.002 · Cited by 62 · see citing works

Cryopreservable neutrophil surrogates. Stored cytoplasts from human polymorphonuclear leukocytes retain chemotactic, phagocytic, and microbicidal function.

Malawista, S. E., Blaricom, G. V., & Breitenstein, M. G. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113939 · Cited by 47 · see citing works

Caenorhabditis elegans as a host model for community-associated methicillin-resistant Staphylococcus aureus

Wu, K., Conly, J. M., McClure-Warnier, J.-A., Elsayed, S., Louie, T., & Zhang, K. (2009) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2009.02765.x · Cited by 46 · see citing works

Cytoplasts made from human blood polymorphonuclear leukocytes with or without heat: preservation of both motile function and respiratory burst oxidase activity.

Malawista, S. E., & Blaricom, G. V. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.2.454 · Cited by 34 · see citing works

Phagocytic capacity of cytokineplasts from human blood polymorphonuclear leukocytes.

Malawista, S. E., & Blaricom, G. V. (1986) · PubMed · Cited by 11 · see citing works

Bench-to-bedside review: Understanding the impact of resistance and virulence factors on methicillin-resistant Staphylococcus aureus infections in the intensive care unit

Skrupky, L. P., Micek, S. T., & Kollef, M. H. (2009) · Critical Care · doi:10.1186/cc8028 · Cited by 5 · see citing works

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death &amp; Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works

Neutrophil recruitment and function in health and inflammation

Kolaczkowska, E., & Kubes, P. (2013) · Nature Reviews Immunology · doi:10.1038/nri3399 · Cited by 5,472 · see citing works

Neutrophil extracellular traps in immunity and disease

Papayannopoulos, V. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.105 · Cited by 3,428 · see citing works

The molecular machinery of regulated cell death

Tang, D., Kang, R., Berghe, T. V., Vandenabeele, P., & Kroemer, G. (2019) · Cell Research · doi:10.1038/s41422-019-0164-5 · Cited by 2,595 · see citing works

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

Berghe, T. V., Linkermann, A., Jouan-Lanhouet, S., Walczak, H., & Vandenabeele, P. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3737 · Cited by 1,735 · see citing works

Inflammation and aging: signaling pathways and intervention therapies

Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443 · see citing works

The multifaceted functions of neutrophils

Mayadas, T. N., Cullere, X., & Lowell, C. A. (2014) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-020712-164023 · Cited by 1,356 · see citing works

Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?

Rosales, C. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00113 · Cited by 1,334 · see citing works

An emerging role for neutrophil extracellular traps in noninfectious disease

Jorch, S. K., & Kubes, P. (2017) · Nature Medicine · doi:10.1038/nm.4294 · Cited by 1,244 · see citing works

The roles of extracellular vesicles in the immune system

Buzás, E. I. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00763-8 · Cited by 1,236 · see citing works

The Neutrophil's Role During Health and Disease.

Liew, P., & Kubes, P. (2019) · Physiological Reviews · doi:10.1152/physrev.00012.2018 · Cited by 1,032 · see citing works

Programmed cell death as a defence against infection

Jørgensen, I., Rayamajhi, M., & Miao, E. A. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2016.147 · Cited by 1,014 · see citing works

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

Schauer, C., Janko, C., Munoz, L. E., Zhao, Y., Kienhöfer, D., Frey, B., Lell, M., Manger, B., Rech, J., Naschberger, E., et al. (2014) · Nature Medicine · doi:10.1038/nm.3547 · Cited by 998 · see citing works

Interplay between inflammation and thrombosis in cardiovascular pathology

Stark, K., & Massberg, S. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00552-1 · Cited by 1,033 · see citing works

NETosis: how vital is it?

Yipp, B. G., & Kubes, P. (2013) · Blood · doi:10.1182/blood-2013-04-457671 · Cited by 998 · see citing works

DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25

Yang, L., Liu, Q., Zhang, X., Liu, X., Zhou, B., Chen, J., Huang, D., Li, J., Li, H., Chen, F., et al. (2020) · Nature · doi:10.1038/s41586-020-2394-6 · Cited by 986 · see citing works

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

Lämmermann, T., Afonso, P. V., Angermann, B., Wang, J. M., Kastenmüller, W., Parent, C. A., & Germain, R. N. (2013) · Nature · doi:10.1038/nature12175 · Cited by 937 · see citing works

Neutrophils at work

Nauseef, W. M., & Borregaard, N. (2014) · Nature Immunology · doi:10.1038/ni.2921 · Cited by 893 · see citing works

Thrombosis: tangled up in NETs

Martinod, K., & Wagner, D. D. (2013) · Blood · doi:10.1182/blood-2013-10-463646 · Cited by 875 · see citing works

Neutrophils and NETS in modulating acute and chronic inflammation

Castanheira, F. V. S., & Kubes, P. (2019) · Blood · doi:10.1182/blood-2018-11-844530 · Cited by 792 · see citing works

A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis

Metzler, K. D., Goosmann, C., Lubojemska, A., Zychlinsky, A., & Papayannopoulos, V. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.06.044 · Cited by 741 · see citing works

COVID-19 update: Covid-19-associated coagulopathy

Becker, R. C. (2020) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-020-02134-3 · Cited by 698 · see citing works

Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview

Delgado‐Rizo, V., Martinez-Guzman, M. A., Íñiguez-Gutiérrez, L., García-Orozco, A., Alvarado‐Navarro, A., & Fafutis‐Morris, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00081 · Cited by 688 · see citing works

Diverse novel functions of neutrophils in immunity, inflammation, and beyond

Mócsai, A. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20122220 · Cited by 678 · see citing works

Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice

McDonald, B., Davis, R. P., Kim, S., Tse, M., Esmon, C. T., Kołaczkowska, E., & Jenne, C. N. (2017) · Blood · doi:10.1182/blood-2016-09-741298 · Cited by 666 · see citing works

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

Krüger, P., Saffarzadeh, M., Weber, A. N. R., Rieber, N. P., Radsak, M. P., von Bernuth, H., Benarafa, C., Roos, D., Skokowa, J., & Hartl, D. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004651 · Cited by 663 · see citing works

DAMPs and NETs in Sepsis

Denning, N., Aziz, M., Gurien, S. D., & Wang, P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02536 · Cited by 632 · see citing works

Life and death of circulating cell-free DNA

Kustanovich, A., Schwartz, R., Peretz, T., & Grinshpun, A. (2019) · Cancer Biology & Therapy · doi:10.1080/15384047.2019.1598759 · Cited by 612 · see citing works

Cellular Mechanisms of NETosis

Thiam, H. R., Wong, S. L., Wagner, D. D., & Waterman, C. M. (2020) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-020520-111016 · Cited by 624 · see citing works

Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature

Kolaczkowska, E., Jenne, C. N., Surewaard, B. G. J., Thanabalasuriar, A., Lee, W.-Y., Sanz, M.-J., Mowen, K., Opdenakker, G., & Kubes, P. (2015) · Nature Communications · doi:10.1038/ncomms7673 · Cited by 584 · see citing works

Neutrophil Extracellular Traps in Atherosclerosis and Atherothrombosis

Döring, Y., Soehnlein, O., & Weber, C. (2017) · Circulation Research · doi:10.1161/circresaha.116.309692 · Cited by 579 · see citing works

Evolving concepts in bone infection: redefining "biofilm", "acute vs. chronic osteomyelitis", "the immune proteome" and "local antibiotic therapy"

Masters, E. A., Trombetta, R. P., de Mesy Bentley, K. L., Boyce, B. F., Gill, A. L., Gill, S. R., Nishitani, K., Ishikawa, M., Morita, Y., Ito, H., et al. (2019) · Bone Research · doi:10.1038/s41413-019-0061-z · Cited by 575 · see citing works

Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

Yoshida, M., Minagawa, S., Araya, J., Sakamoto, T., Hara, H., Tsubouchi, K., Hosaka, Y., Ichikawa, A., Saito, N., Kadota, T., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10991-7 · Cited by 572 · see citing works

NETosis: Molecular Mechanisms, Role in Physiology and Pathology

Vorobjeva, N. V., & Chernyak, B. V. (2020) · Biochemistry (Moscow) · doi:10.1134/s0006297920100065 · Cited by 559 · see citing works

Inflammation and thrombosis: roles of neutrophils, platelets and endothelial cells and their interactions in thrombus formation during sepsis

Iba, T., & Levy, J. H. (2017) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13911 · Cited by 556 · see citing works

Neutrophil extracellular traps in homeostasis and disease

Wang, H., Kim, S. J., Yu, L., Wang, S., Wang, H., Huang, H., Zhang, H., & Tsung, A. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01933-x · Cited by 579 · see citing works

Neutrophils: New insights and open questions

Ley, K. F., Hoffman, H. M., Kubes, P., Cassatella, M. A., Zychlinsky, A., Hedrick, C. C., & Catz, S. D. (2018) · Science Immunology · doi:10.1126/sciimmunol.aat4579 · Cited by 540 · see citing works

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

Martinod, K., Demers, M., Fuchs, T. A., Wong, S. L., Brill, A. G., Gallant, M., Hu, J., Wang, Y., & Wagner, D. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301059110 · Cited by 532 · see citing works

Neutrophil extracellular traps — the dark side of neutrophils

Sørensen, O. E., & Borregaard, N. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84538 · Cited by 532 · see citing works

Regulated cell death and inflammation: an auto-amplification loop causes organ failure

Linkermann, A., Stockwell, B. R., Krautwald, S., & Anders, H.-J. (2014) · Nature Reviews Immunology · doi:10.1038/nri3743 · Cited by 522 · see citing works

Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases

Wigerblad, G., & Kaplan, M. J. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00787-0 · Cited by 519 · see citing works

An overview of the role of neutrophils in innate immunity, inflammation and host-biomaterial integration

Selders, G. S., Fetz, A. E., Radic, M. Z., & Bowlin, G. L. (2017) · Regenerative Biomaterials · doi:10.1093/rb/rbw041 · Cited by 538 · see citing works

NETosis, complement, and coagulation: a triangular relationship

de Bont, C. M., Boelens, W. C., & Pruijn, G. J. M. (2018) · Cellular and Molecular Immunology · doi:10.1038/s41423-018-0024-0 · Cited by 493 · see citing works

Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review

Peltanová, B., Raudenská, M., & Masařík, M. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0983-5 · Cited by 470 · see citing works

NET balancing: a problem in inflammatory lung diseases

Cheng, O. Z., & Palaniyar, N. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00001 · Cited by 453 · see citing works

Macrophage Clearance of Neutrophil Extracellular Traps Is a Silent Process

Farrera, C., & Fadeel, B. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300436 · Cited by 445 · see citing works

To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps

Boeltz, S., Amini, P., Anders, H., Andrade, F., Bilyy, R. O., Chatfield, S. M., Cichoń, I., Clancy, D. M., Desai, J., Dumych, T. I., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-018-0261-x · Cited by 439 · see citing works

NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture

Thiam, H. R., Wong, S. L., Qiu, R., Kittisopikul, M., Vahabikashi, A., Goldman, A. E., Goldman, R. D., Wagner, D. D., & Waterman, C. M. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1909546117 · Cited by 438 · see citing works

The role of neutrophils and NETosis in autoimmune and renal diseases

Gupta, S., & Kaplan, M. J. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.71 · Cited by 433 · see citing works

Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia

Baral, P., Umans, B. D., Li, L., Wallrapp, A., Bist, M., Kirschbaum, T., Wei, Y., Zhou, Y., Kuchroo, V. K., Burkett, P. R., et al. (2018) · Nature Medicine · doi:10.1038/nm.4501 · Cited by 430 · see citing works

Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis

Zhang, H., Wang, Y., Qu, M., Li, W., Wu, D., Cata, J. P., & Miao, C. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1170 · Cited by 429 · see citing works

Neutrophils at the crossroads of innate and adaptive immunity

Rosales, C. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mir0220-574rr · Cited by 372 · see citing works

Liver ischaemia–reperfusion injury: a new understanding of the role of innate immunity

Hirao, H., Nakamura, K., & Kupiec‐Weglinski, J. W. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00549-8 · Cited by 375 · see citing works

Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease

Chen, G., Zhang, D., Fuchs, T. A., Manwani, D., Wagner, D. D., & Frenette, P. S. (2014) · Blood · doi:10.1182/blood-2013-10-529982 · Cited by 354 · see citing works

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis

Huebener, P., Pradère, J., Hernandez, C., Gwak, G., Caviglia, J. M., Mu, X., Loike, J. D., Jenkins, R. E., Antoine, D. J., & Schwabe, R. F. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76887 · Cited by 353 · see citing works

Neutrophil Extracellular Traps: The Biology of Chromatin Externalization

Sollberger, G., Tilley, D. O., & Zychlinsky, A. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.01.019 · Cited by 346 · see citing works

Neutrophil phenotypes and functions in cancer: A consensus statement

Quail, D. F., Amulic, B., Aziz, M., Barnes, B. J., Eruslanov, E. B., Fridlender, Z. G., Goodridge, H. S., Granot, Z., Hidalgo, A., Huttenlocher, A., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20220011 · Cited by 336 · see citing works

NETworking with cancer: The bidirectional interplay between cancer and neutrophil extracellular traps

Adrover, J. M., McDowell, S. A. C., He, X., Quail, D. F., & Egeblad, M. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.001 · Cited by 349 · see citing works

New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation

Yang, H., Biermann, M. H. C., Brauner, J., Liu, Y., Zhao, Y., & i, M. H. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00302 · Cited by 335 · see citing works

Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria.

Gaertner, F., Ahmad, Z., Rosenberger, G., Fan, S.-X., Nicolai, L., Busch, B., Yavuz, G., Luckner, M., Ishikawa-Ankerhold, H., Hennel, R., et al. (2017) · Cell · doi:10.1016/j.cell.2017.11.001 · Cited by 305 · see citing works

The role of extracellular histone in organ injury

Silk, E., Zhao, H., Weng, H., & Ma, D. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.52 · Cited by 331 · see citing works

The Role of HMGB1 in the Pathogenesis of Inflammatory and Autoimmune Diseases

Magna, M., & Pisetsky, D. S. (2014) · Molecular Medicine · doi:10.2119/molmed.2013.00164 · Cited by 358 · see citing works

Neutrophil Extracellular Trap Formation: Physiology, Pathology, and Pharmacology

Ravindran, M., Khan, M. A., & Palaniyar, N. (2019) · Biomolecules · doi:10.3390/biom9080365 · Cited by 328 · see citing works

Molecular mechanisms regulating NETosis in infection and disease

Branzk, N., & Papayannopoulos, V. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0384-6 · Cited by 319 · see citing works

Neutrophil Extracellular Traps in the Second Decade

Brinkmann, V. (2018) · Journal of Innate Immunity · doi:10.1159/000489829 · Cited by 315 · see citing works

Neutrophils Versus Staphylococcus aureus : A Biological Tug of War

Spaan, A. N., Surewaard, B. G. J., Nijland, R., & van Strijp, J. A. G. (2013) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092412-155746 · Cited by 305 · see citing works

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis

Huebener, P., Pradère, J., Hernandez, C., Gwak, G., Caviglia, J. M., Mu, X., Loike, J. D., Jenkins, R. E., Antoine, D. J., & Schwabe, R. F. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126975 · Cited by 301 · see citing works

The role of neutrophils in immune dysfunction during severe inflammation

Leliefeld, P. H. C., Wessels, C. M., Leenen, L. P. H., Koenderman, L., & Pillay, J. (2016) · Critical Care · doi:10.1186/s13054-016-1250-4 · Cited by 298 · see citing works

Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals

Hazeldine, J., Harris, P., Chapple, I., Grant, M. M., Greenwood, H. L., Livesey, A., Sapey, E., & Lord, J. M. (2014) · Aging Cell · doi:10.1111/acel.12222 · Cited by 297 · see citing works

Extracellular histones in tissue injury and inflammation

Allam, R., Kumar, S. V. R., Darisipudi, M. N., & Anders, H. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1148-z · Cited by 293 · see citing works

NETosis markers: Quest for specific, objective, and quantitative markers

Masuda, S., Nakazawa, D., Shida, H., Miyoshi, A., Kusunoki, Y., Tomaru, U., & Ishizu, A. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.05.029 · Cited by 289 · see citing works

Neutrophils in Psoriasis

Chiang, C.-C., Cheng, W.-J., Kořínek, M., Lin, C.-Y., & Hwang, T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02376 · Cited by 294 · see citing works

Neutrophils in innate and adaptive immunity

Jaillon, S., Galdiero, M. R., Prete, D. D., Cassatella, M. A., Garlanda, C., & Mantovani, A. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0374-8 · Cited by 284 · see citing works

Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap–mediated sterile inflammation

Rossaint, J., Herter, J. M., Aken, H. V., Napirei, M., Döring, Y., Weber, C., Soehnlein, O., & Zarbock, A. (2013) · Blood · doi:10.1182/blood-2013-07-516484 · Cited by 278 · see citing works

Neutrophil Extracellular Traps Go Viral

Schönrich, G., & Raftery, M. J. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00366 · Cited by 277 · see citing works

Hepatic platelet and leukocyte adherence during endotoxemia

Croner, R. S., Hoerer, E., Kulu, Y., Hackert, T., Gebhard, M. M., Herfarth, C., & Klar, E. (2006) · Critical Care · doi:10.1186/cc3968 · Cited by 275 · see citing works

The role of platelets in mediating a response to human influenza infection

Koupenova, M., Corkrey, H. A., Vitseva, O. I., Manni, G., Pang, C. J., Clancy, L., Yao, C., Rade, J. J., Levy, D. A., Wang, J. P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09607-x · Cited by 277 · see citing works

Neutrophil Extracellular Traps Induce Trypsin Activation, Inflammation, and Tissue Damage in Mice With Severe Acute Pancreatitis

Merza, M., Hartman, H., Rahman, M., Hwaiz, R. A., Zhang, E., Renström, E., Luo, L., Mörgelin, M., Regnér, S., & Thorlacius, H. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.08.026 · Cited by 277 · see citing works

Neutrophil extracellular traps (NETs) - formation and implications.

Zawrotniak, M., & Rąpała‐Kozik, M. (2013) · Acta Biochimica Polonica · doi:10.18388/abp.2013_1983 · Cited by 273 · see citing works

NETosis: A New Factor in Tumor Progression and Cancer-Associated Thrombosis

Demers, M., & Wagner, D. D. (2014) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0034-1370765 · Cited by 261 · see citing works

Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis

Guglietta, S., Chiavelli, A., Zagato, E., Krieg, C., Gandini, S., Ravenda, P. S., Bazolli, B., Lu, B., Penna, G., & Rescigno, M. (2016) · Nature Communications · doi:10.1038/ncomms11037 · Cited by 257 · see citing works

DNA Is an Antimicrobial Component of Neutrophil Extracellular Traps

Halverson, T. W. R., Wilton, M., Poon, K., Petri, B., & Lewenza, S. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004593 · Cited by 253 · see citing works

Neutrophil extracellular traps are indirectly triggered by lipopolysaccharide and contribute to acute lung injury

Liu, S., Su, X., Pan, P., Zhang, L., Hu, Y., Tan, H., Wu, D., Liu, B., Li, H., Li, H., et al. (2016) · Scientific Reports · doi:10.1038/srep37252 · Cited by 254 · see citing works

The Role of Reactive Oxygen Species (ROS) in the Formation of Extracellular Traps (ETs) in Humans

Stoiber, W., Obermayer, A., Steinbacher, P., & Krautgartner, W.-D. (2015) · Biomolecules · doi:10.3390/biom5020702 · Cited by 250 · see citing works

Neutrophil Extracellular Traps Induced by IL8 Promote Diffuse Large B-cell Lymphoma Progression via the TLR9 Signaling

Nie, M., Yang, L., Bi, X., Wang, Y., Sun, P., Yang, H., Liu, P., Li, Z., Xia, Y., & Jiang, W. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1226 · Cited by 251 · see citing works

The role of microglia and myeloid immune cells in acute cerebral ischemia

Benakis, C., García‐Bonilla, L., Iadecola, C., & Anrather, J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00461 · Cited by 249 · see citing works

Immune-Mediated Pore-Forming Pathways Induce Cellular Hypercitrullination and Generate Citrullinated Autoantigens in Rheumatoid Arthritis

Romero, V., Fert‐Bober, J., Nigrovic, P. A., Darrah, E., Haque, U. J., Lee, D. M., Eyk, J. E. V., Rosen, A., & Andrade, F. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006869 · Cited by 247 · see citing works

Opposition between PKC isoforms regulates histone deimination and neutrophil extracellular chromatin release

Neeli, I., & Radic, M. Z. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00038 · Cited by 248 · see citing works

Neutrophil extracellular traps in cancer

Cristinziano, L., Modestino, L., Antonelli, A., Marone, G., Simon, H., Varricchi, G., & Galdiero, M. R. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.07.011 · Cited by 247 · see citing works

Neutrophil chemotaxis

Petri, B., & Sanz, M. (2018) · Cell and Tissue Research · doi:10.1007/s00441-017-2776-8 · Cited by 247 · see citing works

Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow

Devi, S., Wang, Y., Chew, W. K., Lima, R., A-González, N., Mattar, C. N. Z., Chong, S. Z., Schlitzer, A., Bakočević, N., Chew, S. H. S., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130056 · Cited by 243 · see citing works

A Critical Reappraisal of Neutrophil Extracellular Traps and NETosis Mimics Based on Differential Requirements for Protein Citrullination

Konig, M. F., & Andrade, F. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00461 · Cited by 240 · see citing works

PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock

Martinod, K., Fuchs, T. A., Zitomersky, N. L., Wong, S. L., Demers, M., Gallant, M., Wang, Y., & Wagner, D. D. (2015) · Blood · doi:10.1182/blood-2014-07-587709 · Cited by 237 · see citing works

Neutrophil cytoplasts induce T H 17 differentiation and skew inflammation toward neutrophilia in severe asthma

Krishnamoorthy, N., Douda, D. N., Brüggemann, T. R., Ricklefs, I., Duvall, M. G., Abdulnour, R.-E. E., Martinod, K., Tavares, L. P., Wang, X., Cernadas, M., et al. (2018) · Science Immunology · doi:10.1126/sciimmunol.aao4747 · Cited by 234 · see citing works

Molecular mechanisms and therapeutic target of NETosis in diseases

Huang, J., Hong, W., Wan, M., & Zheng, L. (2022) · MedComm · doi:10.1002/mco2.162 · Cited by 234 · see citing works

Neutrophil swarming: an essential process of the neutrophil tissue response

Kienle, K., & Lämmermann, T. (2016) · Immunological Reviews · doi:10.1111/imr.12458 · Cited by 227 · see citing works

Molecular Mechanisms of mtDNA-Mediated Inflammation

Gaetano, A. D., Solodka, K., Zanini, G., Selleri, V., Mattioli, A. V., Nasi, M., & Pinti, M. (2021) · Cells · doi:10.3390/cells10112898 · Cited by 235 · see citing works

At the Bench: Neutrophil extracellular traps (NETs) highlight novel aspects of innate immune system involvement in autoimmune diseases

Grayson, P. C., & Kaplan, M. J. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.5bt0615-247r · Cited by 228 · see citing works

Role of Platelets in Leukocyte Recruitment and Resolution of Inflammation

Rossaint, J., Margraf, A., & Zarbock, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02712 · Cited by 229 · see citing works

Neutrophils and neutrophil extracellular traps in the liver and gastrointestinal system

Honda, M., & Kubes, P. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.183 · Cited by 227 · see citing works

Reactive oxygen species as signaling molecules in neutrophil chemotaxis

Hattori, H., Subramanian, K. K., Sakai, J., et al. (2010) · Communicative & Integrative Biology · doi:10.4161/cib.3.3.11559 · Cited by 47 · see citing works

Influence of temperature on opsonization and phagocytosis of staphylococci

Peterson, P. K., Verhoef, J., & Quie, P. G. (1977) · Infection and Immunity · doi:10.1128/iai.15.1.175-179.1977 · Cited by 51 · see citing works

ComparativeIn VitroPhagocytosis and F‐Actin Polymerization of Bovine Neonatal Neutrophils*

Moiola, F., Spycher, M. O., Wyder-Walther, M., et al. (1994) · Zentralblatt für Veterinärmedizin Reihe A · doi:10.1111/j.1439-0442.1994.tb00087.x · Cited by 9 · see citing works

Chemotaxis: insights from the extending pseudopod

Haastert, P. J. M. V. (2010) · Journal of Cell Science · doi:10.1242/jcs.071118 · Cited by 62 · see citing works

Comparison of the Effect of Different Opsonins on the Phagocytosis of Fluorescein-Labeled Staphylococcal Bacteria by Chicken Heterophils

Andreasen, C. B., Andreasen, J. R., Sonn, A. E., et al. (1996) · Avian Diseases · doi:10.2307/1592297 · Cited by 8 · see citing works