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Cited by 76Sperm and Testicular FunctionSystemic Lupus Erythematosus ResearchReproductive Biology and Fertility

Testicular Sertoli cell function in male systemic lupus erythematosus

Suehiro, R. M., Borba, E. F., Bonfa, E., Okay, T. S., Cocuzza, M., Soares, P. M. F., Silva, C. A. A.·2008·Rheumatology
DOI 10.1093/rheumatology/ken338
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Abstract

OBJECTIVE: To assess the testicular Sertoli cell function in male SLE patients. METHODS: Thirty-four consecutive patients were prospectively selected to evaluate serum inhibin B. Clinical features, treatment, semen analysis, urological evaluation, testicular ultrasound, hormones and anti-sperm antibodies were determined. RESULTS: Patients were subdivided into two groups: low serum inhibin B (Group 1, n = 8) and normal levels (Group 2, n = 26). The median sperm concentration (P = 0.024), total sperm count (P = 0.023) and total motile sperm count (P = 0.025) were lower in Group 1. Inhibin B levels were positively correlated with sperm concentration (r = 0.343), total motile sperm count (r = 0.357), and negatively correlated with follicule-stimulating hormone (FSH) (r = 0.699) and luteinizing hormone (r = 0.397). The median serum inhibin B was lower in SLE patients treated with intravenous cyclophosphamide (IVCYC) compared with those without this therapy (P = 0.031). Further evaluation of the 26 SLE patients with normal inhibin B and FSH levels revealed that medians of inhibin B/FSH ratio were lower in SLE patients with oligozoospermia compared with normozoospermia (P = 0.004). This ratio was also lower in SLE patients treated with IVCYC than those without this therapy (P = 0.04). In contrast, inhibin B serum level alone did not discriminate the later group of patients (P = 0.12). CONCLUSIONS: This is the first study to identify a high frequency of testicular Sertoli cell dysfunction in male SLE associated with semen abnormalities. Further prospective studies are necessary to determine if inhibin levels and inhibin B/FSH ratio will be an earlier and useful marker of IVCYC toxicity in these patients.

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  • Chronic inflammatory diseases can lead to loss of reproduction potential because affected individuals are at strong disadvantage in competition for food, social status, and sexual partners, and intense inflammation can inhibit the hypothalamic-pituitary-gonadal axis.

    “Chronic inflammatory diseases can lead to loss of reproduction potential because affected individuals are at strong disadvantage. Such individuals can be excluded or impaired in the competition for food; they can also have low social status in the group and limited choice or availability of sexual partners.”

    From Evolutionary medicine and chronic inflammatory state—known and new concepts in pathophysiology (2012) · cites this paper as [20]

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Research works printed but not linked: 5

  1. Rowe PJ, Comhaire FH, Hargreave TB, Mahmoud AM. World Health Organization (WHO) for the standardized investigation, diagnosis and management of the infertile men, 1st edition. Cambridge: Cambridge University Press, 2000;1-86.
  2. World Health Organization (WHO). Laboratory manual for the examination of human semen and sperm-cervical mucus interaction, 4th edition. New York: Cambridge University Press, 1999;1-128.
  3. Folomeev M, Alekberova Z. Impotence in systemic lupus erythematosus. J Rheumatol 1990;17:117-8.
  4. Silva CA, Hallak J, Pasqualotto FF, Barba MF, Saito Ml, Kiss MHB. Gonadal function in adolescents and young men with systemic lupus erythematosus. J Rheumatol 2002;29:2000-5.
  5. Reichlin M, Gilbert G, Haas GG Jr. Association of anti-sperm antibodies with systemic lupus erythematosus. Arthritis Rheum 1985;28:76.

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Authors
Suehiro, R. M., Borba, E. F., Bonfa, E., Okay, T. S., Cocuzza, M., Soares, P. M. F., & Silva, C. A. A.
Affiliations
Universidade de São Paulo (BR)
ORCID
Venue
Rheumatology
Publisher
Oxford University Press (OUP)
Published
2008-08-13
Volume
47
Issue
11
Pages
1692-1697
ISSN
  • 1462-0324 (ISSN-L)
  • 1462-0332
DOI
10.1093/rheumatology/ken338
OpenAlex
W2106235822
Cited by
76
References
36
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 8 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 7 · 2014: 4 · 2013: 4 · 2012: 8
FWCI
6.18
Type
journal article
Language
en
Open access
closed
Locations
  • Lara D. Veeken (publishedVersion)
  • PubMed (publishedVersion)
  • Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
Funders
  • Federico and Elvia Faggin Foundation
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (04/07832-2, 305468/2006-5)
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (305468/2006-5)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
systemic lupus erythematosus, male infertility, Sertoli cell dysfunction, inhibin B, oligozoospermia, semen quality, cyclophosphamide toxicity, follicle-stimulating hormone, luteinizing hormone, antisperm antibodies
MeSH terms
Adolescent, Adult, Autoantibodies, Cyclophosphamide, Follicle Stimulating Hormone, Humans, Immunosuppressive Agents, Inhibins, Luteinizing Hormone, Lupus Erythematosus, Systemic, Male, Middle Aged, Prospective Studies, Sertoli Cells, Sperm Count, Sperm Motility, Spermatozoa, Testis, Ultrasonography, Chi-Square Distribution, Statistics, Nonparametric

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