Haematopoietic stem and progenitor cells in rheumatoid arthritis.
Open accessAbstract
RA is the prototypic chronic inflammatory disease, characterized by progressive articular cartilage and bone destruction. The systemic nature of RA is evidenced by the increased risk of atherosclerosis and lymphoproliferative disorders. Components of both the innate and adaptive immune system are implicated in the pathophysiology of the articular and extra-articular manifestations of the disease. A fundamental process in the onset of RA is the breakdown in self-tolerance. Accelerated ageing of immune cells (immunosenescence) appears to be a major mechanism favouring the disruption of tolerance. Telomere erosion, a hallmark of immunosenescence, is present in lymphoid (naïve and memory T cells) and myeloid (granulocytes) cells in RA. The premature ageing process also involves the haematopoietic stem and progenitor cells (CD34(+) HSPC), thus extending the RA immunopathogenesis to include early events in the shaping of the immune system. This review summarizes current concepts of HSPC ageing and its impact on immune regeneration, highlighting the phenotypic and functional similarities between elderly and RA HSPC.
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Signifying abnormalities in RA T cells, including premature telomere loss, extend to CD34+ hematopoietic progenitor cells, separating antigen recognition from cellular aging.
“Also, the signifying abnormalities in RA T cells, including the premature loss of telomeres, have been extended to CD34+ hematopoietic progenitor cells, separating antigen recognition and cellular aging [64,65].”
From T-cell aging in rheumatoid arthritis (2014) · cites this paper as [65]
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T-cell aging in rheumatoid arthritis
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- Authors
- Colmegna, I., & Weyand, C. M.
- Affiliations
- McGill University Health Centre (CA)
- Venue
- Rheumatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-09-13
- Volume
- 50
- Issue
- 2
- Pages
- 252-260
- ISSN
- 1462-0324 (ISSN-L)
- 1462-0332
- PMC
- PMC3021951
- OpenAlex
- W2165336505
- Cited by
- 37
- References
- 82
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 5 · 2023: 1 · 2022: 6 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 1 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Lara D. Veeken (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (AI044142)
- National Heart, Lung, and Blood Institute (R01HL117913)
- National Institute of Allergy and Infectious Diseases (R01AI044142, R01AI108906, R56AI044142)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR042527)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- rheumatoid arthritis, hematopoietic stem and progenitor cells, immunosenescence, telomere shortening, CD34+ cells, self-tolerance, chronic inflammation, T cells, granulocytes, atherosclerosis, lymphoproliferative disorders
- MeSH terms
- Aging, Arthritis, Rheumatoid, Hematopoietic Stem Cells, Humans, Telomere, Antigens, CD34
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