The DOI matches its Crossref record; 67 of the 68 references it cites were found in a registry or an index.
Anterior insular cortex mediates bodily sensibility and social anxiety
Open accessAbstract
Studies in psychiatry and cognitive neuroscience have reported an important relationship between individual interoceptive accuracy and anxiety level. This indicates that greater attention to one's bodily state may contribute to the development of intense negative emotions and anxiety disorders. We hypothesized that reactivity in the anterior insular cortex underlies the intensity of interoceptive awareness and anxiety. To elucidate this triadic mechanism, we conducted functional magnetic resonance imaging (fMRI) and mediation analyses to examine the relationship between emotional disposition and activation in the anterior insular cortex while participants evaluated their own emotional and bodily states. Our results indicated that right anterior insular activation was positively correlated with individual levels of social anxiety and neuroticism and negatively correlated with agreeableness and extraversion. The results of the mediation analyses revealed that activity in the right anterior insula mediated the activity of neural correlates of interoceptive sensibility and social fear. Our findings suggest that attention to interoceptive sensation affects personality traits through how we feel emotion subjectively in various situations.
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“Studies indicate that socially anxious individuals pay more attention to their internal bodily sensations, resulting in enhanced interoceptive sensibility (Terasawa et al. 2013) and accuracy (Stevens et al. 2011; see Garfinkel et al. 2015, for the distinction between facets of interoception).”
From Interpersonal Physiological Synchrony During Dyadic Joint Action Is Increased by Task Novelty and Reduced by Social Anxiety (2025) · cites this paper as Terasawa et al. 2013
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“Other research has shown that activation of the anterior insula is associated with anxiety level (Terasawa et al., 2013; Mallorquí-Bagué et al., 2014).”
From Mindfulness, Interoception, and the Body: A Contemporary Perspective (2019) · cites this paper as Terasawa et al., 2013
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“In addition, enhanced functional connectivity of thalamo-cortical circuits, including the insula and the medial prefrontal cortex, has been observed in social anxiety disorders (Etkin and Wager, 2007; Gimenez et al., 2012).”
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Interoceptive predictions in the brain
Barrett, L. F., & Simmons, W. K. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3950 · Cited by 1,766
Knowing your own heart: Distinguishing interoceptive accuracy from interoceptive awareness
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The insula: an underestimated brain area in clinical neuroscience, psychiatry, and neurology
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Metadata
- Authors
- Terasawa, Y., Shibata, M., Moriguchi, Y., & Umeda, S.
- Affiliations
- Japan Society for the Promotion of Science (JP)
- Keio University (JP)
- Venue
- Social Cognitive and Affective Neuroscience
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-09-13
- Volume
- 8
- Issue
- 3
- Pages
- 259-266
- ISSN
- 1749-5016 (ISSN-L)
- 1749-5024
- PMC
- PMC3594729
- OpenAlex
- W2097538354
- Cited by
- 224
- References
- 68
- Citations by year
- 2026: 8 · 2025: 19 · 2024: 35 · 2023: 17 · 2022: 13 · 2021: 10 · 2020: 17 · 2019: 16 · 2018: 20 · 2017: 14 · 2016: 9 · 2015: 23 · 2014: 16 · 2013: 6
- FWCI
- 10.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Social Cognitive and Affective Neuroscience (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Keio University
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science (23330201, 23700318, 24120518, 21330168, 24330210, 23390192)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- anterior insula, interoceptive awareness, interoceptive accuracy, social anxiety, social fear, personality traits, neuroticism, agreeableness, extraversion, affective dispositions, mediation analysis
- MeSH terms
- Adult, Analysis of Variance, Anxiety, Awareness, Brain Mapping, Cerebral Cortex, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Oxygen, Surveys and Questionnaires, Reaction Time, Sensation, Social Behavior, Young Adult
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