Cited by 224Psychosomatic Disorders and Their TreatmentsAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeural and Behavioral Psychology Studies

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Anterior insular cortex mediates bodily sensibility and social anxiety

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Terasawa, Yuri, Shibata, Midori, Moriguchi, Yoshiya, Umeda, Satoshi·2013·Social Cognitive and Affective Neuroscience

DOI 10.1093/scan/nss108PMC PMC3594729

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Abstract

Studies in psychiatry and cognitive neuroscience have reported an important relationship between individual interoceptive accuracy and anxiety level. This indicates that greater attention to one's bodily state may contribute to the development of intense negative emotions and anxiety disorders. We hypothesized that reactivity in the anterior insular cortex underlies the intensity of interoceptive awareness and anxiety. To elucidate this triadic mechanism, we conducted functional magnetic resonance imaging (fMRI) and mediation analyses to examine the relationship between emotional disposition and activation in the anterior insular cortex while participants evaluated their own emotional and bodily states. Our results indicated that right anterior insular activation was positively correlated with individual levels of social anxiety and neuroticism and negatively correlated with agreeableness and extraversion. The results of the mediation analyses revealed that activity in the right anterior insula mediated the activity of neural correlates of interoceptive sensibility and social fear. Our findings suggest that attention to interoceptive sensation affects personality traits through how we feel emotion subjectively in various situations.

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Authors: Terasawa, Y., Shibata, M., Moriguchi, Y., & Umeda, S.
Affiliations: Japan Society for the Promotion of Science (JP)
Keio University (JP)
ORCID: Terasawa, Yuri
Shibata, Midori
Moriguchi, Yoshiya
Umeda, Satoshi
Venue: Social Cognitive and Affective Neuroscience
Publisher: Oxford University Press (OUP)
Published: 2012-09-13
Volume: 8
Issue: 3
Pages: 259-266
ISSN: 1749-5016 (ISSN-L)
1749-5024
DOI: 10.1093/scan/nss108
PMC: PMC3594729
OpenAlex: W2097538354
Cited by: 224
References: 68
Citations by year: 2026: 8 · 2025: 19 · 2024: 35 · 2023: 17 · 2022: 13 · 2021: 10 · 2020: 17 · 2019: 16 · 2018: 20 · 2017: 14 · 2016: 9 · 2015: 23 · 2014: 16 · 2013: 6
FWCI: 10.28
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: Social Cognitive and Affective Neuroscience (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Keio University
Ministry of Education, Culture, Sports, Science and Technology
Japan Society for the Promotion of Science (23330201, 23700318, 24120518, 21330168, 24330210, 23390192)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: anterior insula, interoceptive awareness, interoceptive accuracy, social anxiety, social fear, personality traits, neuroticism, agreeableness, extraversion, affective dispositions, mediation analysis
MeSH terms: Adult, Analysis of Variance, Anxiety, Awareness, Brain Mapping, Cerebral Cortex, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Oxygen, Surveys and Questionnaires, Reaction Time, Sensation, Social Behavior, Young Adult

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Anterior insular cortex mediates bodily sensibility and social anxiety

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