The insula: an underestimated brain area in clinical neuroscience, psychiatry, and neurology
Open accessAbstract
Supported by recent human neuroimaging studies, the insula is re-emerging as an important brain area not only in the physiological understanding of the brain, but also in pathological contexts in clinical research. In this opinion article, we briefly introduce the anatomical and histological features of the human insula. We then summarize the physiological functions of the insula and underscore its pathological roles in psychiatric and neurological disorders that have long been underestimated. We finally propose possible strategies through which the role of the insula may be further understood for both basic and clinical neuroscience.
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- Authors
- Namkung, H., Kim, S.-H., & Sawa, A.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Sawa, Akira
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 40
- Issue
- 4
- Pages
- 200-207
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC5538352
- OpenAlex
- W2603776246
- Cited by
- 462
- References
- 72
- Citations by year
- 2026: 59 · 2025: 65 · 2024: 58 · 2023: 58 · 2022: 41 · 2021: 53 · 2020: 48 · 2019: 44 · 2018: 27 · 2017: 9
- FWCI
- 5.31
- Type
- journal article
- Language
- en
- Update notices
- erratum (2018-08-01)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (MH-094268)
- Silvio O. Conte center (MH-092443, MH-105660, DA-040127)
- Stanley
- S-R/RUSK
- NARSAD
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- insula, mental illness, neurological disorders, human neuroimaging
- MeSH terms
- Animals, Mental Disorders, Brain Diseases, Cerebral Cortex, Humans
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