The DOI matches its Crossref record, with a small difference in title or year; 96 of the 96 references it cites were found in a registry or an index.
Mindfulness-based training attenuates insula response to an aversive interoceptive challenge.
Open accessAbstract
Neuroimaging studies of mindfulness training (MT) modulate anterior cingulate cortex (ACC) and insula among other brain regions, which are important for attentional control, emotional regulation and interoception. Inspiratory breathing load (IBL) is an experimental approach to examine how an individual responds to an aversive stimulus. Military personnel are at increased risk for cognitive, emotional and physiological compromise as a consequence of prolonged exposure to stressful environments and, therefore, may benefit from MT. This study investigated whether MT modulates neural processing of interoceptive distress in infantry marines scheduled to undergo pre-deployment training and deployment to Afghanistan. Marines were divided into two groups: individuals who received training as usual (control) and individuals who received an additional 20-h mindfulness-based mind fitness training (MMFT). All subjects completed an IBL task during functional magnetic resonance imaging at baseline and post-MMFT training. Marines who underwent MMFT relative to controls demonstrated a significant attenuation of right anterior insula and ACC during the experience of loaded breathing. These results support the hypothesis that MT changes brain activation such that individuals process more effectively an aversive interoceptive stimulus. Thus, MT may serve as a training technique to modulate the brain's response to negative interoceptive stimuli, which may help to improve resilience.
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“The insula is associated with greater dispositional mindfulness (Creswell et al., 2007; Murakami et al., 2012; Haase et al., 2016), and studies have consistently shown that mindfulness is linked with increased cortical thickness in the aINS (Farb et al., 2007, 2013, 2015; Paulus et al., 2011; Haase et al., 2016).”
From Mindfulness, Interoception, and the Body: A Contemporary Perspective (2019) · cites this paper as Haase et al., 2016
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“Controlled, rhythmic breathing provides a stream of sensory information that has an affective component (Davenport and Vovk, 2009; Haase et al., 2016).”
From Mindfulness, Interoception, and the Body: A Contemporary Perspective (2019) · cites this paper as Haase et al., 2016
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“Attenuation of the right anterior insula and ACC was related to the loaded breathing task (Haase et al., 2014).”
From Enhanced Resting-State Functional Connectivity With Decreased Amplitude of Low-Frequency Fluctuations of the Salience Network in Mindfulness Novices (2022) · cites this paper as Haase et al., 2014
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Citations
Cites
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“Several personality and symptom assessment questionnaires were administered at baseline and post-training including: five facets of mindfulness questionnaire (FFMQ; Baer et al., 2006), designed to measure the five primary facets of mindfulness (observing, describing, acting with awareness, non-judging of inner experie…”
BackgroundMethodInfluentialAFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
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MethodThe Construct of Resilience: A Critical Evaluation and Guidelines for Future Work
Luthar, S. S., Cicchetti, D., & Becker, B. (2000) · Child Development · doi:10.1111/1467-8624.00164 · Cited by 9,381 · cited 2×
“Resilience can be conceptualized as one’s ability to positively adapt to severe stress, trauma and adversity (Luthar et al., 2000), that may help to prevent the development of psychopathology (Campbell-Sills et al.”
BackgroundMindfulness-based interventions in context: Past, present, and future
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“Mindfulness is ‘the awareness that emerges through paying attention on purpose, in the present moment, and non-judgmentally to the unfolding of experience moment by moment’ (Kabat-Zinn, 2003).”
BackgroundMindfulness-based interventions in context: Past, present, and future.
Kabat-Zinn, J. (2003) · Clinical Psychology: Science and Practice · doi:10.1093/clipsy/bpg016 · Cited by 8,612
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“…and symptom assessment questionnaires were administered at baseline and post-training including: five facets of mindfulness questionnaire (FFMQ; Baer et al., 2006), designed to measure the five primary facets of mindfulness (observing, describing, acting with awareness, non-judging of inner…”
Method(2008) · Medical Entomology and Zoology · Cited by 7,477
How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657 · cited 2×
“…connections with subcortical, limbic and executive control brain systems, which allows for the integration of interoceptive signals and hedonic evaluation, such as the anterior cingulate cortex (ACC), amygdala, nucleus accumbens and orbitofrontal cortex (Critchley et al., 2004; Craig, 2009).”
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Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006 · cited 5×
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BackgroundResultInfluentialSaliency, switching, attention and control: a network model of insula function
Menon, V., & Uddin, L. Q. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0262-0 · Cited by 5,592 · cited 2×
“insula and the ACC facilitate cognitive control by switching between the central-executive control network and default-mode network (Sridharan et al., 2008; Menon and Uddin, 2010).”
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“These findings are consistent with an interesting study by Hasse and colleagues [113] showing that 20 h of MMT resulted in changes to the anterior cingulate and insula during exposure to an aversive stimulus in a group of infantry marines about to be deployed to Afghanistan.”
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“…et al., 2004) 前额叶的亚区域激活存在差异。观察到的最一致的发现是在完成正念干预后杏仁核的活动减弱 (Bauer, Caballero et al., 2019; Goldin & Gross, 2010; Hölzel et al., 2010; Kral et al., 2018) ，顶叶的激活都是增加 (Dickenson et al., 2013; Xiao et al., 2019) 。但是，海马、扣带回、岛叶在正念训练对于压力、情绪和疼痛 的激活存在差异 (Grant, Courtemanche, & Rainville, 2011; Haase et…”
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Metadata
- Authors
- Haase, L., Thom, N. J., Shukla, A., Davenport, P. W., Simmons, A. N., Stanley, E. A., Paulus, M. P., & Johnson, D. C.
- Affiliations
- University of California San Diego (US)
- Naval Health Research Center (US)
- University of Florida (US)
- Georgetown University (US)
- Venue
- Social Cognitive and Affective Neuroscience
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-04-08
- Volume
- 11
- Issue
- 1
- Pages
- 182-190
- ISSN
- 1749-5016 (ISSN-L)
- 1749-5024
- PMC
- PMC4692309
- OpenAlex
- W2108033418
- Cited by
- 124
- References
- 94
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 14 · 2023: 8 · 2022: 11 · 2021: 10 · 2020: 10 · 2019: 13 · 2018: 12 · 2017: 4 · 2016: 12 · 2015: 7
- FWCI
- 9.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Social Cognitive and Affective Neuroscience (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Defense
- Center of Excellence for Stress and Mental Health
- University of California, San Diego
- Office of Naval Research
- National Institute of Mental Health (T32-MH018399-26, MH018399, T32MH018399)
- Bureau of Medicine and Surgery
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- mindfulness training, insula, anterior cingulate cortex, interoception, emotion regulation, attentional control, military personnel, pre-deployment training, deployment stress, resilience
- MeSH terms
- Self-Control, Arousal, Attention, Cerebral Cortex, Dominance, Cerebral, Emotions, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Military Personnel, Nerve Net, Resilience, Psychological, Young Adult, Mindfulness, Interoception
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