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Cited by 37Mindfulness and Compassion InterventionsPsychosomatic Disorders and Their TreatmentsAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Increased insula response to interoceptive attention following mindfulness training is associated with increased body trusting among patients with depression

Open access
Datko, Michael, Lutz, Jacqueline, Gawande, Richa, Comeau, Alexandra, To, My Ngoc, Desel, Tenzin, Gan, Jenny, Desbordes, Gaelle, Napadow, Vitaly, Schuman-Olivier, Zev·2022·Psychiatry Research: Neuroimaging
DOI 10.1016/j.pscychresns.2022.111559
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Abstract

Interoceptive dysfunction is often present in anxiety and depression. We investigated the effects of an 8-week intervention, Mindfulness Training for Primary Care (MTPC), on brain mechanisms of interoceptive attention among patients with anxiety and/or depression. We hypothesized that fMRI brain response to interoception in the insula, a region known for interoceptive processing, would increase following the MTPC intervention, and that such increases would be associated with post-intervention changes in self-reported measures of interoceptive awareness. Adults (n = 28) with anxiety and/or depression completed baseline and post-intervention fMRI visits, including a task in which they alternated between focusing on their heartbeat (interoception (INT)) and a control visual attention task (exteroception (EXT)). Following MTPC, we observed increased evoked fMRI response (relative to baseline) in left anterior insula during the INT-EXT task contrast (z > 3.1, p < 0.001 corrected). In patients with moderate-to-severe depression as defined by the Patient Reported Outcomes Measurement Information System (PROMIS), increased post-intervention insula response was associated with increased Body Trusting, a subscale of the Multidimensional Assessment of Interoceptive Awareness (z > 3.1, p = 0.007 corrected). This study demonstrates that patients with mood disorders may respond differentially to mindfulness-based treatment depending on depression severity, and that among those who are more depressed, increased trusting in one's own body sensations and experiencing the body as a safe place to attend to may be necessary components of positive responses to mindfulness-based interventions.

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Crossref · 10.1016/j.pscychresns.2022.111559

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  • MTPC repeatedly demonstrated effectiveness in improving emotion-regulation, enhancing interoceptive awareness, and helping catalyze health behavior change, especially among people with diagnosed PTSD.

    “MTPC to be effective in improving emotion-regulation, enhancing interoceptive awareness, and helping catalyze health behavior change, especially among people with diagnosed PTSD”

    From Integrating choice points into mindfulness training for the dissociative subtype of PTSD: A case report (2024) · cites this paper as Datko et al., 2022

  • Improvements in interoceptive sensibility following these practices are associated with increasing insula responsiveness and reductions in anxiety and depressive symptoms.

    “Improvements in interoceptive sensibility following these practices are associated with increasing insula responsiveness and reductions in anxiety and depressive symptoms [65–67], highlighting a potential mediatory role.”

    From Neural correlates of altered interoception in depressive and anxiety disorders: a systematic review and meta-analysis (2026) · cites this paper as [65]

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  1. Jenkinson, 2012, FSL, 62, 782

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Metadata

Authors
Datko, M., Lutz, J., Gawande, R., Comeau, A., To, M. N., Desel, T., Gan, J., Desbordes, G., Napadow, V., & Schuman-Olivier, Z.
Affiliations
  • Cambridge Health Alliance (US)
  • Massachusetts General Hospital (US)
  • Harvard University (US)
Corresponding author
Datko, Michael
ORCID
Venue
Psychiatry Research: Neuroimaging
Publisher
Elsevier BV
Published
2022-12
Volume
327
Pages
111559
ISSN
0925-4927 (ISSN-L)
DOI
10.1016/j.pscychresns.2022.111559
OpenAlex
W4307042175
Cited by
35
References
51
Citations by year
2026: 6 · 2025: 4 · 2024: 16 · 2023: 9
FWCI
6.61
Type
journal article
Language
en
Open access
Licence
Locations
  • Psychiatry Research Neuroimaging (acceptedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Arnold P. Gold Foundation
  • National Institutes of Health (UH2-AT009145)
  • National Center for Complementary and Integrative Health (UH2AT009145, UH3AT009145, T32AT000051)
  • Common Fund
Topics
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
mindfulness training, interoception, interoceptive attention, insula, interoceptive awareness, depression, anxiety, depression severity, mood disorders
MeSH terms
Adult, Awareness, Brain Mapping, Depression, Humans, Mindfulness, Interoception

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