Shared neural basis of social and non-social reward deficits in chronic cocaine users
Open accessAbstract
Changed reward functions have been proposed as a core feature of stimulant addiction, typically observed as reduced neural responses to non-drug-related rewards. However, it was unclear yet how specific this deficit is for different types of non-drug rewards arising from social and non-social reinforcements. We used functional neuroimaging in cocaine users to investigate explicit social reward as modeled by agreement of music preferences with music experts. In addition, we investigated non-social reward as modeled by winning desired music pieces. The study included 17 chronic cocaine users and 17 matched stimulant-naive healthy controls. Cocaine users, compared with controls, showed blunted neural responses to both social and non-social reward. Activation differences were located in the ventromedial prefrontal cortex overlapping for both reward types and, thus, suggesting a non-specific deficit in the processing of non-drug rewards. Interestingly, in the posterior lateral orbitofrontal cortex, social reward responses of cocaine users decreased with the degree to which they were influenced by social feedback from the experts, a response pattern that was opposite to that observed in healthy controls. The present results suggest that cocaine users likely suffer from a generalized impairment in value representation as well as from an aberrant processing of social feedback.
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Deficits in reward processing occur in major depressive disorder, substance use disorders, posttraumatic stress disorder, schizophrenia, and ADHD.
“Deficits in reward processing are found in MDD (Admon and Pizzagalli, 2015), substance use disorders (Garfield et al., 2014; Tobler et al., 2016), posttraumatic stress disorder (PTSD) (Kalebasi et al., 2015), schizophrenia (McCarthy et al., 2016), and ADHD (van Hulst et al., 2016).”
From The effects of early life stress on reward processing (2018) · cites this paper as Tobler et al., 2016
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The effects of early life stress on reward processing
Novick, A. M., Levandowski, M. L., Laumann, L. E., Philip, N. S., Price, L. H., & Tyrka, A. R. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.02.002 · Cited by 192 · see citing works
“Deficits in reward processing are found in MDD (Admon and Pizzagalli, 2015), substance use disorders (Garfield et al., 2014; Tobler et al., 2016), posttraumatic stress disorder (PTSD) (Kalebasi et al., 2015), schizophrenia (McCarthy et al., 2016), and ADHD (van Hulst et al., 2016).”
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Wang, Y., Li, Y., Liu, B., Zhao, X., Geng, X., Zhu, W., & Ding, X. (2024) · Acta Psychologica · doi:10.1016/j.actpsy.2024.104431 · Cited by 13 · see citing works
- Authors
- Tobler, P. N., Preller, K. H., Campbell-Meiklejohn, D. K., Kirschner, M., Kraehenmann, R., Stämpfli, P., Herdener, M., Seifritz, E., & Quednow, B. B.
- Affiliations
- University of Zurich (CH)
- University of Sussex (GB)
- Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Psychiatric Hospital, 8032 Zurich, Switzerland
- ORCID
- Venue
- Social Cognitive and Affective Neuroscience
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-03-12
- Volume
- 11
- Issue
- 6
- Pages
- 1017-1025
- ISSN
- 1749-5016 (ISSN-L)
- 1749-5024
- PMC
- PMC4884323
- OpenAlex
- W2304927519
- Cited by
- 50
- References
- 41
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 8 · 2017: 2 · 2016: 2
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Social Cognitive and Affective Neuroscience (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- RERO DOC (Universität Bern) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- HighWire Press Open Archive (submittedVersion)
- Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by-nc)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- ETH Zürich Research Collection
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (123516, 150739, 146326, 128574)
- Olga Mayenfisch Stiftung
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- cocaine dependence, social reward, ventromedial prefrontal cortex, orbitofrontal cortex, social feedback, value representation, stimulant use disorder
- MeSH terms
- Adult, Brain Mapping, Female, Humans, Interpersonal Relations, Magnetic Resonance Imaging, Male, Middle Aged, Reward, Social Perception, Prefrontal Cortex, Cocaine-Related Disorders
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