Functional changes of the reward system underlie blunted response to social gaze in cocaine users
Open accessAbstract
Significance: Social interaction deficits in drug users likely impede treatment, increase the burden of the affected families, and consequently contribute to the high costs for society associated with addiction. However, the neural origin contributing to altered social interaction in drug users is unknown thus far. The present study illuminates the nature of basic social interaction deficits as exemplified by social gaze behavior in cocaine users by applying behavioral, psychophysiological, and functional brain-imaging methods. The results suggest that basal social interaction impairments probably arise from blunted social reward processing that was again related to impaired real-life social behavior in cocaine users. These results point to the importance of reinstatement of social reward in the treatment of stimulant addiction.
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Cocaine use leads to a markedly blunted activation of the social reward system.
“cocaine use leads to a markedly blunted activation of the social reward system (Preller et al., 2014).”
From Social functioning in major depressive disorder (2016) · cites this paper as Preller et al., 2014
Social interaction might be even less rewarding in depressed patients who consume cocaine.
“social interaction might be even less rewarding in depressed patients who consume cocaine”
From Social functioning in major depressive disorder (2016) · cites this paper as Preller et al., 2014
Difficulties in social interaction abilities contribute to the maintenance or worsening of psychiatric symptoms.
“Not only do difficulties in social interaction abilities increase the risk of developing a psychiatric disorder, but they also contribute to the maintenance or worsening of symptoms”
From Modulation of Social Cognition via Hallucinogens and “Entactogens” (2019) · cites this paper as [5]
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Self-citation
- Authors
- Preller, K. H., Herdener, M., Schilbach, L., Stämpfli, P., Hulka, L. M., Vonmoos, M., Ingold, N., Vogeley, K., Tobler, P. N., Seifritz, E., & Quednow, B. B.
- Affiliations
- University of Zurich (CH)
- University of Cologne (DE)
- Forschungszentrum Jülich (DE)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-01-21
- Volume
- 111
- Issue
- 7
- Pages
- 2842-2847
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3932870
- OpenAlex
- W2084791579
- Cited by
- 104
- References
- 59
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 8 · 2023: 2 · 2022: 11 · 2021: 7 · 2020: 7 · 2019: 13 · 2018: 13 · 2017: 9 · 2016: 13 · 2015: 9 · 2014: 3
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (123516)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- cocaine dependence, social gaze, social reward processing, reward systems, medial orbitofrontal cortex, social interaction deficits, pupil response, eye contact, social network size, emotional engagement
- MeSH terms
- Adult, Eye Movements, Fixation, Ocular, Humans, Interpersonal Relations, Magnetic Resonance Imaging, Middle Aged, Reward, Social Behavior Disorders, Switzerland, Cocaine-Related Disorders, Neuroimaging
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