Cited by 169Neural and Behavioral Psychology StudiesDecision-Making and Behavioral EconomicsNeurotransmitter Receptor Influence on Behavior

Orbitofrontal contributions to value-based decision making: evidence from humans with frontal lobe damage

Fellows, Lesley K.·2011·Annals of the New York Academy of Sciences

Abstract

The work described here aims to isolate the component processes of decision making that rely critically on particular subregions of the human prefrontal cortex, with a particular focus on the orbitofrontal cortex. Here, experiments isolating specific aspects of decision making, using very simple preference judgment and reinforcement learning paradigms, were carried out in patients with focal frontal damage. The orbitofrontal cortex and the adjacent ventromedial prefrontal cortex play a critical role in decisions based on subjective value, across many categories of stimuli, and in learning to choose between stimuli based on value feedback. However, these regions are not required for learning to choose between actions based on feedback, which instead seems to rely critically on the dorsomedial prefrontal cortex. These results point to a potentially common role for the orbitofrontal cortex in representing the context-sensitive, subjective value of stimuli to allow consistent choices between them. They also argue for multiple, parallel, value-based processes that influence behavior through dissociable mechanisms.

Integrity signals

Registry

Crossref · 10.1111/j.1749-6632.2011.06229.x

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Lesions of the OFC can impair behavioural changes to non-reward; in humans, reward reversal learning is impaired, with continued responding to the previously rewarded, now non-rewarded, stimulus.

    “Consistent with this neurophysiological and neuroimaging evidence, lesions of the OFC can impair behavioural changes to non-reward. For example, reward reversal learning is impaired during decision-making in humans, who continue responding to the previously rewarded, now non-rewarded, stimulus (Rolls et al., 1994; Hornak et al., 2004; Fellows, 2011).”

    From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Fellows, 2011

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Fellows, L. K.
Affiliations
McGill University (CA)
Corresponding author
Fellows, Lesley K.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2011-12
Volume
1239
Issue
1
Pages
51-58
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
OpenAlex
W1950138029
Cited by
169
References
37
Citations by year
2026: 1 · 2025: 11 · 2024: 5 · 2023: 11 · 2022: 7 · 2021: 6 · 2020: 43 · 2019: 4 · 2018: 10 · 2017: 15 · 2016: 17 · 2015: 16 · 2014: 11 · 2013: 6 · 2012: 5
FWCI
0.62
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Pennsylvania
  • Canadian Institutes of Health Research (MOP-77583)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
orbitofrontal cortex, value-based decision making, frontal lobe damage, ventromedial prefrontal cortex, dorsomedial prefrontal cortex, subjective value, reinforcement learning, preference judgments
MeSH terms
Animals, Brain Damage, Chronic, Brain Injuries, Brain Mapping, Decision Making, Frontal Lobe, Humans, Models, Psychological, Neurons, Reinforcement, Psychology, Reversal Learning, Social Values

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review