Epidemiology of First-Episode Psychosis: Illustrating the Challenges Across Diagnostic Boundaries Through the Cavan-Monaghan Study at 8 Years

Baldwin, P.

doi:10.1093/schbul/sbi025

Cited by 153Schizophrenia research and treatmentBipolar Disorder and TreatmentMental Health Treatment and Access

Epidemiology of First-Episode Psychosis: Illustrating the Challenges Across Diagnostic Boundaries Through the Cavan-Monaghan Study at 8 Years

Baldwin, P.·2005·Schizophrenia Bulletin

DOI 10.1093/schbul/sbi025

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Abstract

The epidemiology of first-episode psychosis is poorly understood because of the paucity of systematic studies, yet it constitutes the fundamental basis for understanding the disorder and the foundations on which clinical, biological, therapeutic, and long-term outcome studies are built. A particular need is to clarify the diagnostic breadth of first-episode psychosis and, on this basis, to undertake systematic comparisons across representative populations of the psychoses, to include comparisons with first-episode mania. Considered here is the new generation of prospective studies that may be able to inform in some way on these issues. Attainment of the above goals requires prolonged accrual of "all" cases of nonaffective, affective, and any other psychotic illness, including first-episode mania, to derive the required representative populations. To illustrate some of the challenges, the structure of the Cavan-Monaghan prospective first episode study is described and its interim findings are outlined, as rural Ireland provides psychiatric care based on strict catchment areas and is characterized by substantive ethnic and socioeconomic homogeneity and stability. It is argued that there are 3 primary diagnostic nodes (schizophrenia spectrum psychosis, bipolar disorder, and major depressive disorder with psychotic features) around which there exist numerous additional, overlapping, and well-populated diagnostic categories that are distinct only in terms of their operational definition. Only through systematic, epidemiologically based studies that access this intrinsic diversity are we likely to understand fully the origins and pathobiology of first-episode psychosis.

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People who suffer a first episode of psychosis are frequently adolescents or young adults.
“People who suffer a first episode of psychosis (FEP) are frequently adolescents or young adults [1, 2]”
From Mindfulness-based social cognition training (SocialMIND) versus psychoeducational multicomponent intervention for people with a first episode of psychosis: A study protocol for a randomised controlled trial (2019) · cites this paper as [1]

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others. Epidemiology of first-episode psychosis: illustrating the challenges across diagnostic boundaries through the Cavan-Monaghan study at 8 years
Baldwin, P. A., Browne, D. J., Scully, P. J., John, F., Morgan, M. G., Kinsella, A., John, M., Russell, V., & Waddington, J. L. (2015)
Self-citation
Systematic epidemiological and clinical comparisons across all 12 DSM-IV psychotic diagnoses in the Cavan–Monaghan First Episode Psychosis Study (CAMFEPS)
Nkire, N., Scully, P. J., Browne, D. J., Baldwin, P. A., Kingston, T., Owoeye, O., Kinsella, A., O’Callaghan, E., Russell, V., & Waddington, J. L. (2019) · Psychological Medicine · doi:10.1017/s0033291719003520 · Cited by 18 · see citing works
Self-citation
The Cavan-Monaghan First Episode Psychosis Study (CAMFEPS): arbitrary diagnostic boundaries across the gene–environment interface and within evolving models of care
Waddington, J. L., & Russell, V. (2019) · Irish Journal of Psychological Medicine · doi:10.1017/ipm.2019.11 · Cited by 8 · see citing works
Epidemiological and Clinical Characterization Following a First Psychotic Episode in Major Depressive Disorder: Comparisons With Schizophrenia and Bipolar I Disorder in the Cavan-Monaghan First Episode Psychosis Study (CAMFEPS)
Owoeye, O., Kingston, T., Scully, P. J., Baldwin, P. A., Browne, D. J., Kinsella, A., Russell, V., O’Callaghan, E., & Waddington, J. L. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt075 · Cited by 58 · see citing works
Self-citation
A Six Year Follow-up of the Cavan/Monaghan First Episode Psychosis Study
Kingston, T. (2010) · doi:10.25419/rcsi.10815317

Authors: Baldwin, P.
Affiliations: St. Davnet's Hospital (IE)
Corresponding author: Baldwin, P.
Venue: Schizophrenia Bulletin
Publisher: Oxford University Press (OUP)
Published: 2005-07-27
Volume: 31
Issue: 3
Pages: 624-638
ISSN: 0586-7614 (ISSN-L)
1745-1707
DOI: 10.1093/schbul/sbi025
OpenAlex: W2115309432
Cited by: 153
References: 96
Citations by year: 2026: 1 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 15 · 2018: 11 · 2017: 7 · 2016: 9 · 2015: 5 · 2014: 4 · 2013: 10 · 2012: 5
FWCI: 4.01
Type: journal article
Language: en
Open access: closed
Locations: Schizophrenia Bulletin (publishedVersion)
PubMed (publishedVersion)
Funders: Stanley Medical Research Institute
Royal College of Surgeons in Ireland
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords: first-episode psychosis
MeSH terms: Adolescent, Adult, Aged, Diagnosis, Differential, Ethnicity, Female, Humans, Ireland, Male, Middle Aged, Terminology as Topic, Prospective Studies, Psychotic Disorders, Research Design, Social Class, Prevalence, Epidemiologic Studies

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Epidemiology of First-Episode Psychosis: Illustrating the Challenges Across Diagnostic Boundaries Through the Cavan-Monaghan Study at 8 Years

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