The DOI matches its Crossref record; 232 of the 233 references it cites were found in a registry or an index.
Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoring
Open accessAbstract
Over the last 2 decades, a large number of neurophysiological and neuroimaging studies of patients with schizophrenia have furnished in vivo evidence for dysconnectivity, ie, abnormal functional integration of brain processes. While the evidence for dysconnectivity in schizophrenia is strong, its etiology, pathophysiological mechanisms, and significance for clinical symptoms are unclear. First, dysconnectivity could result from aberrant wiring of connections during development, from aberrant synaptic plasticity, or from both. Second, it is not clear how schizophrenic symptoms can be understood mechanistically as a consequence of dysconnectivity. Third, if dysconnectivity is the primary pathophysiology, and not just an epiphenomenon, then it should provide a mechanistic explanation for known empirical facts about schizophrenia. This article addresses these 3 issues in the framework of the dysconnection hypothesis. This theory postulates that the core pathology in schizophrenia resides in aberrant N-methyl-D-aspartate receptor (NMDAR)-mediated synaptic plasticity due to abnormal regulation of NMDARs by neuromodulatory transmitters like dopamine, serotonin, or acetylcholine. We argue that this neurobiological mechanism can explain failures of self-monitoring, leading to a mechanistic explanation for first-rank symptoms as pathognomonic features of schizophrenia, and may provide a basis for future diagnostic classifications with physiologically defined patient subgroups. Finally, we test the explanatory power of our theory against a list of empirical facts about schizophrenia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Computational psychiatry studies have done exactly this – for instance, using conductance-based neural mass models to infer synaptic changes in disorders like schizophrenia from M/EEG recordings (25, 26).”
From Predictive coding and neurocomputational psychiatry: a mechanistic framework for understanding mental disorders (2026) · cites this paper as [25]
Experimental — accuracy not yet measuredIn the citing paper
“It is of interest to note that similar Bayesian theories have previously been stated in the context of schizophrenia (63, 68, 89–92).”
From Can Bayesian Theories of Autism Spectrum Disorder Help Improve Clinical Practice? (2016) · cites this paper as [89]
In the citing paper
“This model, and variants thereof, has already found widespread application to other psychiatric disorders with perceptual aberrations, in particular schizophrenia (63, 89, 90, 92, 107).”
From Can Bayesian Theories of Autism Spectrum Disorder Help Improve Clinical Practice? (2016) · cites this paper as [89]
In the citing paper
“A prominent and consistent pathophysiological characteristic that has emerged in schizophrenia involves impaired synaptic connectivity (Stephan et al., 2009)”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Stephan et al., 2009
In the citing paper
“A prominent and consistent pathophysiological characteristic that has emerged in schizophrenia involves impaired synaptic connectivity (Stephan et al., 2009)”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Stephan et al., 2009
In the citing paper
“Overall, studies conducted in SCZ suggest that this dysconnectivity may rely at the microscale on impaired control of synaptic plasticity, 40 notably of NMDAdependent plasticity.41,42”
From Are hallucinations due to an imbalance between excitatory and inhibitory influences on the brain? (2016) · cites this paper as [42]
In the citing paper
“Others have linked hallucinations to a failure to attenuate the sensory consequences of inner speech, in analogy to the mechanism that is thought to underlie delusions of control.42,124,135”
From Are hallucinations due to an imbalance between excitatory and inhibitory influences on the brain? (2016) · cites this paper as [42]
In the citing paper
“Such a possibility would be akin to the cycles of demyelination and remyelination often experienced by patients with multiple sclerosis 72 : cycles that have been shown to be associated with fluctuations in conduction velocity 46 and symptomatology, including psychotic symptomatology.[73][74][75]”
From Schizophrenia, myelination, and delayed corollary discharges: a hypothesis (2012) · cites this paper as [73]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388
A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Lindemann, L., Jaeschke, G., Michalon, A., Vieira, E., Honer, M., Spooren, W., Porter, R., Hartung, T., Kolczewski, S., Büttelmann, B., et al. (1909) · JAMA · doi:10.1001/jama.1909.02550020033007 · Cited by 7,889
Rao, R. P. N., & Ballard, D. H. (1999) · Nature Neuroscience · doi:10.1038/4580 · Cited by 5,483
Friston, K. J., Harrison, L., & Penny, W. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00202-7 · Cited by 4,583
Self-citationA theory of cortical responses.
Friston, K. (2005) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2005.1622 · Cited by 4,578
Self-citationDementia Praecox or the Group of Schizophrenias
(1951) · Journal of the American Medical Association · doi:10.1001/jama.1951.02920270079043 · Cited by 4,407
Recent advances in the phencyclidine model of schizophrenia
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.10.1301 · Cited by 2,904
Kapur, S. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.1.13 · Cited by 2,813
Early selective-attention effect on evoked potential reinterpreted
Näätänen, R., Gaillard, A. W. K., & Mäntysalo, S. (1978) · Acta Psychologica · doi:10.1016/0001-6918(78)90006-9 · Cited by 2,725
Das Reafferenzprinzip: Wechselwirkungen zwischen Zentralnervensystem und Peripherie
von Holst, E., & Mittelstaedt, H. (1950) · Naturwissenschaften · doi:10.1007/bf00622503 · Cited by 2,655
Research works printed but not linked: 17
- Friston, 1995, Clinical neuroscience (New York, N.Y.), 3, 89
- Olney, 1995, Archives of General Psychiatry, 52, 998, 10.1001/archpsyc.52.12.998 · DOI
- 2005, Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 360, 815
- 2000, PNAS, 97, 3661, 10.1073/pnas.050350297 · DOI
- 2000, 27, 349
- 1995, International clinical psychopharmacology, 10, 87
- 2000, Psychological medicine, 3, 1131
- 2007, 55, 919
- 2000, 27, 611
- 2007, 18, 159
- 1999, 22, 615
- Bentaleb, 2002, Journal of psychiatry & neuroscience : JPN, 27, 110
- 2005, 46, 681
- 2007, Journal of neural transmission. Supplementum, 72, 269
- 2000, 28, 53
- 2003, 39, 641
- Arnold, 1991, Archives of General Psychiatry, 48, 625, 10.1001/archpsyc.48.7.625 · DOI
Cited by
Sorted by citations
Items 301–400 of 1,001
Huang, C., Luo, Q., Palaniyappan, L. K., Yang, A. C., Hung, C., Chou, K., Lo, C. Z., Liu, M., Tsai, S., Barch, D. M., et al. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.01.010 · Cited by 60
Turkheimer, F., Leech, R., Expert, P., Lord, L.-D., & Vernon, A. C. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.014 · Cited by 55
Differential Patterns of Dysconnectivity in Mirror Neuron and Mentalizing Networks in Schizophrenia
Schilbach, L., Derntl, B., Aleman, A., Caspers, S., Clos, M., Diederen, K. M. J., Gruber, O., Kogler, L., Liemburg, E. J., Sommer, I. E., et al. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw015 · Cited by 58
Observing the Observer (II): Deciding When to Decide
Jean Daunizeau, A., den Ouden, H. E. M., Pessiglione, M., Kiebel, S. J., Friston, K. J., & Stephan, K. E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015555 · Cited by 67
Self-citationBachiller, A., Poza, J., Gómez, C., Molina, V., Suazo, V., & Hornero, R. (2014) · Journal of Neural Engineering · doi:10.1088/1741-2560/12/1/016007 · Cited by 55
Understanding aberrant white matter development in schizophrenia: an avenue for therapy?
Walterfang, M., Velakoulis, D., Whitford, T. J., & Pantelis, C. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.76 · Cited by 55
White Matter Differences Among Adolescents Reporting Psychotic Experiences
O’Hanlon, E., Leemans, A., Kelleher, I., Clarke, M. C., Roddy, S., Coughlan, H., Harley, M., Amico, F., Hoscheit, M. J., Tiedt, L., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.0137 · Cited by 57
Wu, L., Caprihan, A., Bustillo, J., Mayer, A. R., & Calhoun, V. D. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.06.024 · Cited by 60
Urbanicity: The need for new avenues to explore the link between urban living and psychosis
Empson, L. A., Baumann, P., Söderström, O., Codeluppi, Z., Söderström, D., & Conus, P. (2019) · Early Intervention in Psychiatry · doi:10.1111/eip.12861 · Cited by 63
Spontaneous Prediction Error Generation in Schizophrenia
Yamashita, Y., & Tani, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037843 · Cited by 53
Tønnesen, S., Kaufmann, T., Doan, N. T., Alnæs, D., Córdova‐Palomera, A., van der Meer, D., Rokicki, J., Moberget, T., Gurholt, T. P., Haukvik, U. K., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-32355-9 · Cited by 55
de Bartolomeis, A., Manchia, M., Marmo, F., Vellucci, L., Iasevoli, F., & Barone, A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00369 · Cited by 54
Shaw, A. D., Knight, L., Freeman, T. C. A., Williams, G. M., Moran, R. J., Friston, K. J., Walters, J. T. R., & Singh, K. D. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz066 · Cited by 54
Guest, P. C., Iwata, K., Kato, T. A., Steiner, J. H., Schmitt, A., Turck, C. W., & Martins‐de‐Souza, D. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00180 · Cited by 53
Castillo-Passi, R. I., Rojo, L. E., Henríquez‐Henríquez, M., Hernán Silva, I., Maturana, A., Villar, M. J., Fuentes, M., & Gaspar, P. A. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00488 · Cited by 59
Aberrant resting-state functional connectivity of salience network in first-episode schizophrenia
Huang, H., Zeng, B., Jiang, Y., Tang, Y., Zhang, T., Tang, X., Xu, L., Wang, J., Li, J., Qian, Z., et al. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00040-8 · Cited by 53
On the neurobiology of hallucinations
Boksa, P. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0934 · Cited by 54
Bayesian inference, predictive coding and delusions
Adams, R. A., Brown, H. R., & Friston, K. J. (2014) · Avant · doi:10.26913/50302014.0112.0004 · Cited by 55
Self-citationMechanisms of Auditory Verbal Hallucination in Schizophrenia
Cho, R., & Wu, W. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00155 · Cited by 54
Delusions as Forensically Disturbing Perceptual Inferences
Hohwy, J., & Rajan, V. (2011) · Neuroethics · doi:10.1007/s12152-011-9124-6 · Cited by 52
Cortes-Briones, J., Cahill, J. D., Skosnik, P. D., Mathalon, D. H., Williams, A. H., Sewell, R. A., Roach, B. J., Ford, J. M., Ranganathan, M., & D’Souza, D. C. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.023 · Cited by 52
Functional network connectivity in early-stage schizophrenia
Hummer, T. A., Yung, M. G., Goñi, J., Conroy, S. K., Francis, M., Mehdiyoun, N. F., & Breier, A. F. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.01.023 · Cited by 51
A neurobiological perspective on social influence: Serotonin and social adaptation
Duerler, P., Vollenweider, F. X., & Preller, K. H. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15607 · Cited by 52
Thalamic‐insular dysconnectivity in schizophrenia: Evidence from structural equation modeling
Corradi‐Dell’Acqua, C., Tomelleri, L., Bellani, M., Rambaldelli, G., Cerini, R., Mucelli, R. P., Balestrieri, M., Tansella, M., & Brambilla, P. (2011) · Human Brain Mapping · doi:10.1002/hbm.21246 · Cited by 52
Effects of MIR137 on fronto-amygdala functional connectivity
Mothersill, O., Morris, D. W., Kelly, S., Rose, E. J., Fahey, C., O'Brien, C. L., Lyne, R., Reilly, R. B., Gill, M., Corvin, A. P., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.12.019 · Cited by 53
Sanderson, T. M., Côtel, M.-C., O’Neill, M. J., Tricklebank, M. D., Collingridge, G. L., & Sher, E. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.005 · Cited by 51
Guo, W., Liu, F., Chen, J., Wu, R., Zhang, Z., Yu, M., Xiao, C., & Zhao, J. (2015) · Scientific Reports · doi:10.1038/srep17275 · Cited by 51
Ebdrup, B. H., Raghava, J. M., Nielsen, M. Ø., Rostrup, E., & Glenthoj, B. Y. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.150030 · Cited by 54
Examining resting-state functional connectivity in first-episode schizophrenia with 7T fMRI and MEG
Lottman, K. K., Gawne, T. J., Kraguljac, N. V., Killen, J. F., Reid, M. A., & Lahti, A. C. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101959 · Cited by 48
Zick, J. L., Blackman, R. K., Crowe, D. A., Amirikian, B., DeNicola, A. L., Netoff, T. I., & Chafee, M. V. (2018) · Neuron · doi:10.1016/j.neuron.2018.05.010 · Cited by 50
Recovering a sense of self in schizophrenia
Davidson, L. (2019) · Journal of Personality · doi:10.1111/jopy.12471 · Cited by 52
TCF4 (e2‐2; ITF2): A schizophrenia‐associated gene with pleiotropic effects on human disease
Navarrete, K., Pedroso, I., de Jong, S., Stefánsson, H., Steinberg, S., Stefánsson, K., Ophoff, R. A., Schalkwyk, L. C., & Collier, D. A. (2012) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32109 · Cited by 50
A Neural Model of the Loss of Self in Schizophrenia
Taylor, J. G. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq033 · Cited by 50
Meta-connectomics: human brain network and connectivity meta-analyses
Crossley, N. A., Fox, P. T., & Bullmore, E. T. (2016) · Psychological Medicine · doi:10.1017/s0033291715002895 · Cited by 51
Moutin, E., Nikonenko, I., Stefanelli, T., Wirth, A., Ponimaskin, E. G., Roo, M. D., & Müller, D. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw183 · Cited by 50
Chung, Y., Haut, K. M., He, G. S., van Erp, T. G. M., McEwen, S. C., Addington, J., Bearden, C. E., Cadenhead, K. S., Cornblatt, B. A., Mathalon, D. H., et al. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.02.014 · Cited by 50
Functional network dysconnectivity as a biomarker of treatment resistance in schizophrenia
McNabb, C. B., Tait, R. J., McIlwain, M., Anderson, V. M., Suckling, J., Kydd, R. R., & Russell, B. R. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.10.015 · Cited by 48
Dauvermann, M. R., Whalley, H. C., Romaniuk, L., Valton, V., Owens, D. G. C., Johnstone, E. C., Lawrie, S. M., & Moorhead, T. W. J. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.01.063 · Cited by 49
Role of N-Methyl D-aspartate receptors in action-based predictive coding deficits in schizophrenia
Kort, N. S., Ford, J. M., Roach, B. J., Gunduz-Bruce, H., Krystal, J. H., Jaeger, J., Reinhart, R. M. G., & Mathalon, D. H. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.06.019 · Cited by 48
Hamilton, H., D’Souza, D. C., Ford, J. M., Roach, B. J., Kort, N. S., Ahn, K.-H., Bhakta, S. G., Ranganathan, M., & Mathalon, D. H. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.06.040 · Cited by 49
Langland‐Hassan, P. (2020) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1544 · Cited by 55
Gallagher, S. (2014) · Review of Philosophy and Psychology · doi:10.1007/s13164-014-0222-3 · Cited by 48
Lehmann, D., Faber, P. L., Pascual-Marqui, R. D., Milz, P., Herrmann, W. M., Koukkou, M., Saito, N. H., Winterer, G., & Kochi, K. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00635 · Cited by 49
Hirjak, D., Breyer, T., Thomann, P. A., & Fuchs, T. A. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073662 · Cited by 47
Exploring intermediate phenotypes with EEG: Working memory dysfunction in schizophrenia
Haenschel, C., & Linden, D. E. J. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.08.045 · Cited by 54
De Novo Truncating Mutation in Kinesin 17 Associated with Schizophrenia
Tarabeux, J., Champagne, N., Brustein, E., Hamdan, F. F., Gauthier, J., Lapointe, M., Maios, C., Piton, A., Spiegelman, D., Henrion, É., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.018 · Cited by 52
Lottman, K. K., Kraguljac, N. V., White, D. M., Morgan, C. J., Calhoun, V. D., Butt, A., & Lahti, A. C. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00014 · Cited by 49
White matter connectivity disruptions in early and chronic schizophrenia
Biase, M. A. D., Cropley, V., Baune, B. T., Olver, J. S., Amminger, G. P., Phassouliotis, C., Bousman, C., McGorry, P. D., Everall, I., Pantelis, C., et al. (2017) · Psychological Medicine · doi:10.1017/s0033291717001313 · Cited by 49
Grent-‘t-Jong, T., Gajwani, R., Groß, J., Gumley, A. I., Krishnadas, R., Lawrie, S. M., Schwannauer, M., Schultze‐Lutter, F., & Uhlhaas, P. J. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2020.0284 · Cited by 46
Gao, Z., Xiao, Y., Zhu, F., Tao, B., Yu, W., & Lui, S. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105144 · Cited by 52
Optimizing Experimental Design for Comparing Models of Brain Function
Jean Daunizeau, A., Preuschoff, K., Friston, K. J., & Stephan, K. E. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002280 · Cited by 52
Self-citationRobinson, J. D., Wagner, N., & Northoff, G. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv102 · Cited by 47
Conscious and unconscious performance monitoring: Evidence from patients with schizophrenia
Charles, L., Gaillard, R., Amado, I., Krebs, M., Bendjemaa, N., & Dehaene, S. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.09.056 · Cited by 49
Koide, T., Banno, M., Aleksić, B., Yamashita, S., Kikuchi, T., Kohmura, K., Adachi, Y., Kawano, N., Kushima, I., Nakamura, Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036836 · Cited by 46
Dodell‐Feder, D., DeLisi, L. E., & Hooker, C. I. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.03.031 · Cited by 51
Wu, G., Wang, Y., Mwansisya, T. E., Pu, W., Zhang, H., Liu, C., Yang, Q. H., Chen, E. Y. H., Xue, Z., Liu, Z., et al. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.06.033 · Cited by 47
Abnormal effective connectivity and psychopathological symptoms in the psychosis high-risk state
Schmidt, A., Smieskova, R., Simon, A. E., Allen, P., Fusar‐Poli, P., McGuire, P. K., Bendfeldt, K., Aston, J., Lang, U. E., Walter, M., et al. (2014) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130102 · Cited by 46
Vai, B., Papa, G. S., Poletti, S., Radaelli, D., Donnici, E., Bollettini, I., Falini, A., Cavallaro, R., Smeraldi, E., & Benedetti, F. (2015) · European Psychiatry · doi:10.1016/j.eurpsy.2015.01.002 · Cited by 49
Kani, A. S., Shinn, A. K., Lewandowski, K. E., & Öngür, D. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.10.012 · Cited by 46
Collin, G., Nieto-Castañón, A., Shenton, M. E., Pasternak, O., Kelly, S., Keshavan, M. S., Seidman, L. J., McCarley, R. W., Niznikiewicz, M. A., Li, H., et al. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.102108 · Cited by 46
Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoring
Drubach, D. A. (2009) · Yearbook of Neurology and Neurosurgery · doi:10.1016/s0513-5117(09)79121-5 · Cited by 45
Reduced susceptibility to the sound-induced flash fusion illusion in schizophrenia
Vanes, L. D., White, T. P., Wigton, R. L., Joyce, D. W., Collier, T., & Shergill, S. S. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.08.016 · Cited by 46
Gómez‐Pilar, J., Poza, J., Bachiller, A., Gómez, C., Nùñez, P., Lubeiro, A., Molina, V., & Hornero, R. (2017) · International Journal of Neural Systems · doi:10.1142/s0129065717500320 · Cited by 46
Thiebes, S., Leicht, G., Ćurić, S., Steinmann, S., Polomac, N., Andreou, C., Eichler, I., Eichler, L., Zöllner, C., Gallinat, J., et al. (2017) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.160187 · Cited by 43
Huang, H., Jiang, Y., Xia, M., Tang, Y., Zhang, T., Cui, H., Wang, J., Li, Y., Xu, L., Curtin, A., et al. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.10.044 · Cited by 46
Kupferschmidt, D. A., & Gordon, J. A. (2018) · Brain and Neuroscience Advances · doi:10.1177/2398212818771821 · Cited by 46
Bridging the Gap? Altered Thalamocortical Connectivity in Psychotic and Psychedelic States
Avram, M., Rogg, H. V., Korda, A. I., Andreou, C., Müller, F., & Borgwardt, S. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.706017 · Cited by 49
Tian, L., Meng, C., Yan, H., Zhao, Q., Liu, Q., Yan, J., Han, Y., Yuan, H., Wang, L., Yue, W., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028794 · Cited by 44
Aberrant effective connectivity in schizophrenia patients during appetitive conditioning
Diaconescu, A. O., Jensen, J., Wang, H., Willeit, M., Menon, M., Kapur, S., & McIntosh, A. R. (2011) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2010.00239 · Cited by 43
Structural basis of the fronto-thalamic dysconnectivity in schizophrenia: A combined DCM-VBM study
Wagner, G., Koch, K., Schachtzabel, C., Schultz, C. C., Gaser, C., Reichenbach, J. R., Sauer, H., Bär, K., & Schlösser, R. G. M. (2013) · NeuroImage Clinical · doi:10.1016/j.nicl.2013.07.010 · Cited by 49
Reality monitoring impairment in schizophrenia reflects specific prefrontal cortex dysfunction
Garrison, J. R., Fernández-Egea, E., Zaman, R., Agius, M. A., & Simons, J. S. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.01.028 · Cited by 53
Learning stable and predictive network-based patterns of schizophrenia and its clinical symptoms
Gheiratmand, M., Rish, I., Cecchi, G., Brown, M. R. G., Greiner, R., Polosecki, P. I., Bashivan, P., Greenshaw, A. J., Ramasubbu, R., & Dursun, S. M. (2017) · Schizophrenia · doi:10.1038/s41537-017-0022-8 · Cited by 44
Ramsay, I. S., Fryer, S. L., Boos, A. K., Roach, B. J., Fisher, M., Loewy, R. L., Vinogradov, S., & Mathalon, D. H. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.213 · Cited by 46
Fan, Y., Li, Z., Duan, X., Xiao, J., Guo, X., Han, S., Guo, J., Yang, S., Li, J., Cui, Q., et al. (2019) · Human Brain Mapping · doi:10.1002/hbm.24801 · Cited by 43
Revisiting Functional Dysconnectivity: a Review of Three Model Frameworks in Schizophrenia
Harikumar, A., Solovyeva, K. P., Misiura, M. B., Iraji, A., Plis, S., Pearlson, G. D., Turner, J. A., & Calhoun, V. D. (2023) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-023-01325-8 · Cited by 50
Hu, X., Zhang, J., Jin, C., Mi, W., Wang, F., Ma, W., Ma, C., Yang, Y., Li, W., Zhang, H., et al. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.12.007 · Cited by 42
Brain structural and functional dissociated patterns in schizophrenia
Zhuo, C., Zhu, J., Wang, C., Qu, H., Ma, X., Tian, H., Liu, M., & Qin, W. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1194-5 · Cited by 43
Allen, P., Sommer, I. E., Jardri, R., Eysenck, M. W., & Hugdahl, K. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.02.004 · Cited by 43
Drug repositioning for psychiatric and neurological disorders through a network medicine approach
Dias, T. L., Schuch, V., Beltrão-Braga, P. C. B., Martins‐de‐Souza, D., Brentani, H., Franco, G. R., & Nakaya, H. I. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0827-5 · Cited by 44
Psychosis spectrum illnesses as disorders of prefrontal critical period plasticity
Vinogradov, S., Chafee, M. V., Lee, E. G., & Morishita, H. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01451-w · Cited by 44
Altered dynamic coupling of lateral occipital complex during visual perception in schizophrenia
Harvey, P., Lee, J., Cohen, M. S., Engel, S. A., Glahn, D. C., Nuechterlein, K. H., Wynn, J. K., & Green, M. F. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.12.045 · Cited by 44
Connectomics in Schizophrenia: From Early Pioneers to Recent Brain Network Findings
Collin, G., Turk, E., & van den Heuvel, M. P. (2016) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.01.002 · Cited by 45
Model-based dynamical analysis of functional disconnection in schizophrenia
Bányai, M., Diwadkar, V. A., & Érdi, P. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.06.046 · Cited by 40
Auditory hallucinations: Expectation–perception model
Nazimek, J. M., Hunter, M. D., & Woodruff, P. W. R. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.03.014 · Cited by 41
Relationships between early age at onset of psychotic symptoms and treatment resistant schizophrenia
Iasevoli, F., Razzino, E., Altavilla, B., Avagliano, C., Barone, A., Ciccarelli, M., D’Ambrosio, L., Matrone, M., Milandri, F., Francesco, D. N., et al. (2021) · Early Intervention in Psychiatry · doi:10.1111/eip.13174 · Cited by 42
Cattarinussi, G., Giorgio, A. D., Moretti, F., Bondi, E., & Sambataro, F. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110827 · Cited by 52
Bhandari, A., Voineskos, D., Daskalakis, Z. J., Rajji, T. K., & Blumberger, D. M. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00045 · Cited by 43
Hirjak, D., Kubera, K. M., Thomann, P. A., & Wolf, R. C. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.10.007 · Cited by 45
Childhood Trauma Associated White Matter Abnormalities in First-Episode Schizophrenia
Asmal, L., Kilian, S., du Plessis, S., Scheffler, F., Chiliza, B., Fouché, J., Seedat, S., Dazzan, P., & Emsley, R. A. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sby062 · Cited by 46
Lang, X., Zhu, D., Zhang, G., Du, X., Jia, Q., Yin, G., Chen, D., Xiu, M., Cao, B., Wang, L., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0346-9 · Cited by 45
Schizophrenia Exhibits Bi-directional Brain-Wide Alterations in Cortico-Striato-Cerebellar Circuits
Ji, J. L., Diehl, C., Schleifer, C. H., Tamminga, C. A., Keshavan, M. S., Sweeney, J. A., Clementz, B. A., Hill, S. K., Pearlson, G. D., Yang, G., et al. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy306 · Cited by 44
Krekelberg, B. (2010) · Current Biology · doi:10.1016/j.cub.2009.12.018 · Cited by 50
Usun, Y., Eybrard, S., Meyer, F., & Louilot, A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.08.017 · Cited by 46
Fragmentation: loss of global coherence or breakdown of modularity in functional brain architecture?
van den Berg, D., Gong, P., Breakspear, M. J., & van Leeuwen, C. (2012) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2012.00020 · Cited by 42
Wolff, A., & Northoff, G. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02337-z · Cited by 43
Yoon, Y., Yun, J.-Y., Jung, W., Kang, I.-C. K., Kim, S., Lee, T., Park, H., & Kwon, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135347 · Cited by 46
Mwansisya, T. E., Wang, Z., Tao, H., Zhang, H., Hu, A., Guo, S., & Liu, Z. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.07.018 · Cited by 41
Vrana, A., Boendermaker, S. H., Stämpfli, P., Hänggi, J., Seifritz, E., Humphreys, B. K., & Meier, M. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142391 · Cited by 41
Silverstein, B. H., Bressler, S. L., & Diwadkar, V. A. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00132 · Cited by 42
Houck, J. M., Çetin, M. S., Mayer, A. R., Bustillo, J., Stephen, J. M., Aine, C. J., Cañive, J. M., Perrone‐Bizzozero, N. I., Thoma, R. J., Brookes, M. J., et al. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.10.011 · Cited by 42
Metadata
- Authors
- Stephan, K. E., Friston, K. J., & Frith, C. D.
- Affiliations
- Wellcome Centre for Human Neuroimaging (GB)
- Corresponding author
- Stephan, K. E.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-03-30
- Volume
- 35
- Issue
- 3
- Pages
- 509-527
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- PMC
- PMC2669579
- OpenAlex
- W2095651675
- Semantic Scholar
- 8cfeb68228d86d29ef7a86331cbc4aefac1a2e9b
- Cited by
- 1,134
- References
- 233
- Citations by year
- 2026: 45 · 2025: 41 · 2024: 43 · 2023: 49 · 2022: 54 · 2021: 81 · 2020: 79 · 2019: 59 · 2018: 80 · 2017: 91 · 2016: 87 · 2015: 79 · 2014: 63 · 2013: 101 · 2012: 67
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Schizophrenia Bulletin (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by-nc-sa)
- UCL Discovery (University College London) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by-nc-sa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Wellcome Trust (056750, 088130)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- schizophrenia, dysconnectivity
- MeSH terms
- Acetylcholine, Awareness, Brain, Delusions, Dopamine, Electroencephalography, Hallucinations, Humans, Magnetic Resonance Imaging, Nerve Net, Neuronal Plasticity, Reality Testing, Schizophrenia, Schizophrenic Psychology, Serotonin, Synapses, Magnetoencephalography, Receptors, N-Methyl-D-Aspartate
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
