Synaptic plasticity and dysconnection in schizophrenia

Stephan, Klaas E.; Baldeweg, Torsten; Friston, Karl J.

doi:10.1016/j.biopsych.2005.10.005

Cited by 841Schizophrenia research and treatmentNeuroscience and Neuropharmacology ResearchFunctional Brain Connectivity Studies

Synaptic plasticity and dysconnection in schizophrenia

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Stephan, Klaas E., Baldeweg, Torsten, Friston, Karl J.·2006·Biological Psychiatry

DOI 10.1016/j.biopsych.2005.10.005

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Abstract

Current pathophysiological theories of schizophrenia highlight the role of altered brain connectivity. This dysconnectivity could manifest 1) anatomically, through structural changes of association fibers at the cellular level, and/or 2) functionally, through aberrant control of synaptic plasticity at the synaptic level. In this article, we review the evidence for these theories, focusing on the modulation of synaptic plasticity. In particular, we discuss how dysconnectivity, observed between brain regions in schizophrenic patients, could result from abnormal modulation of N-methyl-D-aspartate (NMDA)-dependent plasticity by other neurotransmitter systems. We focus on the implication of the dysconnection hypothesis for functional imaging at the systems level. In particular, we review recent advances in measuring plasticity in the human brain using functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) that can be used to address dysconnectivity in schizophrenia. Promising experimental paradigms include perceptual and reinforcement learning. We describe how theoretical and causal models of brain responses might contribute to a mechanistic understanding of synaptic plasticity in schizophrenia.

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The findings support the proposed role of abnormal modulation of synaptic efficacy in the pathophysiology of schizophrenia.
“These findings support the proposed role of abnormal modulation of synaptic efficacy in the pathophysiology of schizophrenia (Friston and Frith, 1995, Friston, 1998, Stephan et al., 2006).”
From The functional anatomy of schizophrenia: A dynamic causal modeling study of predictive coding (2014) · cites this paper as Stephan et al., 2006
In the context of psychiatric disorders, the availability of behavioral or brain activity measurements suggests that validated generative models could be developed into clinically applicable 'computational assays,' in analogy to biochemical assays in internal medicine.
“In the context of psychiatric disorders, the relatively straightforward availability of behavioral or brain activity measurements suggests that validated generative models could be developed into clinically applicable “computational assays,” in analogy to biochemical assays in internal medicine (63).”
From Can Bayesian Theories of Autism Spectrum Disorder Help Improve Clinical Practice? (2016) · cites this paper as [63]
Similar Bayesian theories have previously been stated in the context of schizophrenia.
“It is of interest to note that similar Bayesian theories have previously been stated in the context of schizophrenia (63, 68, 89–92).”
From Can Bayesian Theories of Autism Spectrum Disorder Help Improve Clinical Practice? (2016) · cites this paper as [63]
This model and variants thereof have already found widespread application to other psychiatric disorders with perceptual aberrations, in particular schizophrenia.
“This model, and variants thereof, has already found widespread application to other psychiatric disorders with perceptual aberrations, in particular schizophrenia (63, 89, 90, 92, 107).”
From Can Bayesian Theories of Autism Spectrum Disorder Help Improve Clinical Practice? (2016) · cites this paper as [63]
Numerous neurophysiological studies have provided evidence for signaling of prediction errors along forward connections and predictions along backward connections.
“Numerous neurophysiological studies have provided evidence for signaling of prediction errors along forward connections and predictions along backward connections [(63, 72) for reviews see (126, 127)].”
From Can Bayesian Theories of Autism Spectrum Disorder Help Improve Clinical Practice? (2016) · cites this paper as [63]

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Foong, J., Symms, M. R., Barker, G. J., Maier, M., Miller, D. H., & Ron, M. A. (2002) · Neuroreport · doi:10.1097/00001756-200203040-00017 · Cited by 150 · see citing works
Effect of ketamine on the neuromagnetic mismatch field in healthy humans
Kreitschmann‐Andermahr, I., Rosburg, T., Demme, U., Gaser, E., Nowak, H., & Sauer, H. (2001) · Cognitive Brain Research · doi:10.1016/s0926-6410(01)00043-x · Cited by 144 · see citing works
Diffusion tensor imaging (DTI) and proton magnetic resonance spectroscopy (1H MRS) in schizophrenic subjects and normal controls
Steel, R. M., Bastin, M. E., McConnell, S., Marshall, I., Owens, D. G. C., Lawrie, S. M., Johnstone, E. C., & Best, J. J. K. (2001) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(01)00080-4 · Cited by 138 · see citing works
Mechanisms by which Dopamine Receptors May Influence Synaptic Plasticity
Wolf, M. E., Mangiavacchi, S., & Sun, X. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.015 · Cited by 136 · see citing works
Dimensional complexity of EEG brain mechanisms in untreated schizophrenia
Koukkou, M., Lehmann, D., Wackermann, J., Dvořák, I., & Henggeler, B. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90167-c · Cited by 127 · see citing works
Long-term Potentiation Induces Expanded Movement Representations and Dendritic Hypertrophy in Layer V of Rat Sensorimotor Neocortex
Monfils, M. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh020 · Cited by 124 · see citing works
Nicotinic modulation of human auditory sensory memory: Evidence from mismatch negativity potentials
Baldeweg, T., WONG, D., & Stephan, K. E. (2005) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2005.07.014 · Cited by 123 · see citing works
Self-citation
Intact Implicit Learning in Schizophrenia
Danion, J., Meulemans, T., Kauffmann-Muller, F., & Vermaat, H. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.6.944 · Cited by 119 · see citing works
Mismatch negativity in schizophrenia: a family study
Bramon, E. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00132-4 · Cited by 116 · see citing works
N400 and Automatic Semantic Processing Abnormalities in Patients With Schizophrenia
Mathalon, D. H., Faustman, W. O., & Ford, J. M. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.7.641 · Cited by 115 · see citing works
Dysfunctional connectivity in schizophrenia.
Friston, K. J. (2002) · Europe PMC (PubMed Central) · Cited by 114 · see citing works
Self-citation
Separation of mismatch negativity and the N1 wave in the auditory cortex of the cat: a topographic study
Pincze, Z., Lakatos, P., Rajkai, C., Ulbert, I., & Karmos, G. (2001) · Clinical Neurophysiology · doi:10.1016/s1388-2457(01)00509-0 · Cited by 107 · see citing works
Book Review: Neural Network Models of Schizophrenia
Hoffman, R. E., & McGlashan, T. H. (2001) · The Neuroscientist · doi:10.1177/107385840100700513 · Cited by 103 · see citing works
Auditory Sensory Memory and the Cholinergic System: Implications for Alzheimer's Disease
Pekkonen, E., Hirvonen, J., Jääskeläinen, I. P., Kaakkola, S., & Huttunen, J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0805 · Cited by 102 · see citing works
Association between reduced duration mismatch negativity (MMN) and raised temporal discrimination thresholds in schizophrenia
Todd, J., Michie, P. T., & Jablensky, A. V. (2003) · Clinical Neurophysiology · doi:10.1016/s1388-2457(03)00246-3 · Cited by 101 · see citing works
A disturbance of nonlinear interdependence in scalp EEG of subjects with first episode schizophrenia
Breakspear, M. J., Terry, J. R., Friston, K. J., Harris, A. W. F., Williams, L. M., Brown, K. J., Brennan, J., & Gordon, E. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00332-x · Cited by 99 · see citing works
Self-citation
Determinants of the auditory mismatch response
Imada, T., Hari, R., Loveless, N. E., McEvoy, L. K., & Sams, M. E. (1993) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(93)90120-k · Cited by 98 · see citing works
Chronic Haloperidol Promotes Corticostriatal Long-Term Potentiation by Targeting Dopamine D2L Receptors
Centonze, D., Usiello, A., Costa, C., Picconi, B., Erbs, E., Bernardi, G., Borrelli, E., & Calabresi, P. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1274-04.2004 · Cited by 96 · see citing works
Mismatch negativity (MMN): an objective measure of sensory memory and long-lasting memories during sleep
Atienza, M., Cantero, J. L., & Dominguez-Marin, E. (2002) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(02)00113-7 · Cited by 96 · see citing works
Effects of sequential and temporal probability of deviant occurrence on mismatch negativity
Sabri, M., & Campbell, K. B. (2001) · Cognitive Brain Research · doi:10.1016/s0926-6410(01)00026-x · Cited by 93 · see citing works
Corpus callosum size and inter-hemispheric function in schizophrenia
Woodruff, P. W. R., Phillips, M. L., Rushe, T., Wright, I. C., Murray, R. M., & David, A. S. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(96)00103-x · Cited by 93 · see citing works
Activation of muscarinic receptors induces protein synthesis‐dependent long‐lasting depression in the perirhinal cortex
Massey, P. V., Bhabra, G., Cho, K., Brown, M. W., & Bashir, Z. I. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01631.x · Cited by 90 · see citing works
Disconnection and Cognitive Dysmetria in Schizophrenia
Friston, K. J. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.3.429 · Cited by 86 · see citing works
Self-citation
Combined event-related fMRI and intracerebral ERP study of an auditory oddball task
Brázdil, M., Dobšík, M., Mikl, M., Hluštı́k, P., Daniel, P., Pažourková, M., Krůpa, P., & Rektor, I. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.01.051 · Cited by 85 · see citing works
Acute effect of nicotine on auditory gating in smokers and non-smokers
Harkrider, A. W., & Hedrick, M. S. (2004) · Hearing Research · doi:10.1016/j.heares.2004.11.009 · Cited by 84 · see citing works
The effect of deviant stimulus probability on the human mismatch process
Sato, Y., Yabe, H., Hiruma, T., Sutoh, T., Shinozaki, N., Nashida, T., & Kaneko, S. (2000) · Neuroreport · doi:10.1097/00001756-200011270-00023 · Cited by 84 · see citing works
Brain interactions in chronic schizophrenics under resting and activation conditions
Volkow, N. D., Wolf, A. P., Brodie, J. D., Cancro, R., Overall, J. E., Rhoades, H. M., & Gelder, P. V. (1988) · Schizophrenia Research · doi:10.1016/0920-9964(88)90039-4 · Cited by 80 · see citing works
Global, Regional, and Local Measures of Complexity of Multichannel Electroencephalography in Acute, Neuroleptic-Naive, First-Break Schizophrenics
Saito, N. H., Kuginuki, T., Yagyu, T., Kinoshita, T., Koenig, T. W., Pascual-Marqui, R. D., Kochi, K., Wackermann, J., & Lehmann, D. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00547-7 · Cited by 80 · see citing works
Effect of deviant probability and interstimulus/interdeviant interval on the auditory N1 and mismatch negativity in the cat auditory cortex
Pincze, Z., Lakatos, P., Rajkai, C., Ulbert, I., & Karmos, G. (2002) · Cognitive Brain Research · doi:10.1016/s0926-6410(01)00105-7 · Cited by 68 · see citing works
Intracranial identification of an electric frontal-cortex response to auditory stimulus change: a case study
Liasis, A. C., Towell, A., Alho, K., & Boyd, S. G. (2001) · Cognitive Brain Research · doi:10.1016/s0926-6410(00)00077-x · Cited by 66 · see citing works
Induction of long‐term depression is associated with decreased dendritic length and spine density in layers III and V of sensorimotor neocortex
Monfils, M., & Teskey, G. C. (2004) · Synapse · doi:10.1002/syn.20039 · Cited by 65 · see citing works
EEG coherence of prefrontal areas in normal and schizophrenic males during perceptual activation
Hoffman, R. E., Buchsbaum, M. S., Escobar, M. D., Makuch, R., Nuechterlein, K. H., & Guich, S. (1991) · Journal of Neuropsychiatry · doi:10.1176/jnp.3.2.169 · Cited by 56 · see citing works
Cholinergic modulation of synaptic transmission and plasticity in entorhinal cortex and hippocampus of the rat
Yun, S. H., Cheong, M. Y., Mook‐Jung, I., Huh, K. H., Lee, C.-J., & Jung, M. W. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00108-1 · Cited by 54 · see citing works
Implicit learning of visuospatial sequences in schizophenia.
Schwartz, B. L., Howard, D. V., Howard, J. H., Hovaguimian, A., & Deutsch, S. I. (2003) · Neuropsychology · doi:10.1037/0894-4105.17.3.517 · Cited by 54 · see citing works
Stepping out of the spotlight: MMN attenuation as a function of distance from the attended location
Arnott, S. R., & Alain, C. (2002) · Neuroreport · doi:10.1097/00001756-200212030-00009 · Cited by 53 · see citing works
Contribution of AMPA and NMDA receptors to excitatory responses in the inferior colliculus
Kelly, J. B., & Zhang, H. (2002) · Hearing Research · doi:10.1016/s0378-5955(02)00372-6 · Cited by 53 · see citing works
Convergence of neural systems processing stimulus associations and coordinating motor responses
McIntosh, A. R. (1998) · Cerebral Cortex · doi:10.1093/cercor/8.7.648 · Cited by 38 · see citing works
N-methyl-d-aspartate antagonists as drug models of schizophrenia: a surprising link to tobacco smoking
Domino, E. F., Mirzoyan, D., & Tsukada, H. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.05.024 · Cited by 24 · see citing works
Structural Abnormalities of Subicular Dendrites in Subjects With Schizophrenia and Mood Disorders: Preliminary Findings
Rosoklija, G., Toomayan, G., Ellis, S. P., Keilp, J., Mann, J. J., Latov, N., Hays, A. P., & Dwork, A. J. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.4.349 · Cited by 1 · see citing works

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Bayesian model selection for group studies
Stephan, K. E., Penny, W. D., Daunizeau, J., Moran, R. J., & Friston, K. J. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.03.025 · Cited by 1,423 · see citing works
Self-citation
The mismatch negativity: a review of underlying mechanisms
Garrido, M. I., Kilner, J. M., Stephan, K. E., & Friston, K. J. (2009) · Clinical Neurophysiology · doi:10.1016/j.clinph.2008.11.029 · Cited by 1,441 · see citing works
“Two features make the MMN a particularly interesting paradigm for schizophrenia research (see Stephan et al., 2006, for a review).”
BackgroundSelf-citation
Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies
Brown, A. S., & Derkits, E. J. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09030361 · Cited by 1,269 · see citing works
Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring
Stephan, K. E., Friston, K. J., & Frith, C. D. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn176 · Cited by 1,134 · see citing works
Self-citation
The Computational Anatomy of Psychosis
Adams, R. A., Stephan, K. E., Brown, H. R., Frith, C. D., & Friston, K. J. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00047 · Cited by 850 · see citing works
“NMDA-Rs play a central role in theories of schizophrenia (Olney and Farber, 1995; Abi-Saab et al., 1998; Goff and Coyle, 2001; Stephan et al., 2006; Corlett et al., 2011).”
BackgroundSelf-citation
Schizophrenia, neuroimaging and connectomics
Fornito, A., Zalesky, A., Pantelis, C., & Bullmore, E. T. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.12.090 · Cited by 716 · see citing works
Meta-analysis of diffusion tensor imaging studies in schizophrenia
Ellison-Wright, I., & Bullmore, E. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2008.11.021 · Cited by 715 · see citing works
Dysconnectivity in schizophrenia: where are we now?
Pettersson-Yeo, W., Allen, P., Benetti, S., McGuire, P., & Mechelli, A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.11.004 · Cited by 712 · see citing works
Development of structure–function coupling in human brain networks during youth
Baum, G. L., Cui, Z., Roalf, D. R., Ciric, R., Betzel, R. F., Larsen, B., Cieslak, M., Cook, P. A., Xia, C. H., Moore, T. M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1912034117 · Cited by 544 · see citing works
Disrupted axonal fiber connectivity in schizophrenia
Zalesky, A., Fornito, A., Seal, M. L., Cocchi, L., Westin, C.-F., Bullmore, E. T., Egan, G. F., & Pantelis, C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.022 · Cited by 439 · see citing works
An anatomical substrate for integration among functional networks in human cortex
van den Heuvel, M. P., & Sporns, O. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2128-13.2013 · Cited by 404 · see citing works
Toward a neurobiology of delusions
Corlett, P. R., Taylor, J. R., Wang, X.-J., Fletcher, P. C., & Krystal, J. H. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.06.007 · Cited by 394 · see citing works
Neural Mechanisms of a Genome-Wide Supported Psychosis Variant
Esslinger, C., Walter, H., Kirsch, P., Erk, S., Schnell, K., Arnold, C., Haddad, L., Mier, D., Opitz von Boberfeld, C., Raab, K., et al. (2009) · Science · doi:10.1126/science.1167768 · Cited by 400 · see citing works
Hierarchical Prediction Errors in Midbrain and Basal Forebrain during Sensory Learning
Iglesias, S., Mathys, C., Brodersen, K. H., Kasper, L., Piccirelli, M., den Ouden, H. E. M., & Stephan, K. E. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.009 · Cited by 342 · see citing works
Self-citation
A Bayesian perspective on magnitude estimation
Petzschner, F. H., Glasauer, S., & Stephan, K. E. (2015) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.03.002 · Cited by 327 · see citing works
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Synapse Pathology in Psychiatric and Neurologic Disease
van Spronsen, M., & Hoogenraad, C. C. (2010) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-010-0104-8 · Cited by 345 · see citing works
Linking oligodendrocyte and myelin dysfunction to neurocircuitry abnormalities in schizophrenia
Takahashi, N., Sakurai, T., Davis, K. L., & Buxbaum, J. D. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.09.004 · Cited by 337 · see citing works
Systematic reviews of categorical versus continuum models in psychosis: evidence for discontinuous subpopulations underlying a psychometric continuum. Implications for DSM-V, DSM-VI, and DSM-VII
Linscott, R. J., & van Os, J. (2010) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.032408.153506 · Cited by 324 · see citing works
Striatal Prediction Error Modulates Cortical Coupling
den Ouden, H. E. M., Daunizeau, J., Roiser, J., Friston, K. J., & Stephan, K. E. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4458-09.2010 · Cited by 304 · see citing works
Self-citation
An integrative perspective on the role of dopamine in schizophrenia
Maia, T. V., & Frank, M. J. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.05.021 · Cited by 293 · see citing works
Computational psychiatry: towards a mathematically informed understanding of mental illness
Adams, R. A., Huys, Q. J. M., & Roiser, J. P. (2015) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2015-310737 · Cited by 285 · see citing works
Small worlds inside big brains
Sporns, O., & Honey, C. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609523103 · Cited by 307 · see citing works
Computational approaches to psychiatry
Stephan, K. E., & Mathys, C. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.12.007 · Cited by 260 · see citing works
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NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
Anticevic, A., Gancsos, M., Murray, J. D., Repovs, G., Driesen, N. R., Ennis, D. J., Niciu, M. J., Morgan, P. T., Surti, T. S., Bloch, M. H., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208494109 · Cited by 243 · see citing works
Glutamatergic model psychoses: prediction error, learning, and inference
Corlett, P. R., Honey, G. D., Krystal, J. H., & Fletcher, P. C. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.163 · Cited by 229 · see citing works
From prediction error to psychosis: Ketamine as a pharmacological model of delusions
Corlett, P. R., Honey, G. D., & Fletcher, P. C. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881107077716 · Cited by 227 · see citing works
Reduced prefrontal-parietal effective connectivity and working memory deficits in schizophrenia
Deserno, L., Sterzer, P., Wüstenberg, T., Heinz, A., & Schlagenhauf, F. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3405-11.2012 · Cited by 214 · see citing works
Analyzing effective connectivity with functional magnetic resonance imaging
Stephan, K. E., & Friston, K. J. (2010) · WIREs Cognitive Science · doi:10.1002/wcs.58 · Cited by 202 · see citing works
Self-citation
Activity-dependent neural plasticity from bench to bedside
Ganguly, K., & Poo, M.-M. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.028 · Cited by 202 · see citing works
Computational psychosomatics and computational psychiatry: Toward a joint framework for differential diagnosis
Petzschner, F. H., Weber, L. A. E., Gard, T., & Stephan, K. E. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.05.012 · Cited by 181 · see citing works
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Reward feedback alterations in unmedicated schizophrenia patients: Relevance for delusions
Schlagenhauf, F., Sterzer, P., Schmack, K., Ballmaier, M., Rapp, M., Wrase, J., Juckel, G., Gallinat, J., & Heinz, A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.12.016 · Cited by 195 · see citing works
Dynamic causal models of steady-state responses
Moran, R. J., Stephan, K. E., Seidenbecher, T., Pape, H.-C., Dolan, R. J., & Friston, K. J. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.09.048 · Cited by 195 · see citing works
Self-citation
Understanding why patients with schizophrenia do not perceive the hollow-mask illusion using dynamic causal modelling
Dima, D., Roiser, J. P., Dietrich, D. E., Bonnemann, C., Lanfermann, H., Emrich, H. M., & Dillo, W. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.03.033 · Cited by 192 · see citing works
Translational perspectives for computational neuroimaging
Stephan, K. E., Iglesias, S., Heinzle, J., & Diaconescu, A. O. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.008 · Cited by 169 · see citing works
Self-citation
Misattribution of speech and impaired connectivity in patients with auditory verbal hallucinations
Mechelli, A., Allen, P., Amaro, E., Fu, C. H. Y., Williams, S. C. R., Brammer, M. J., Johns, L. C., & McGuire, P. K. (2007) · Human Brain Mapping · doi:10.1002/hbm.20341 · Cited by 175 · see citing works
Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia
Takao, K., Kobayashi, K., Hagihara, H., Ohira, K., Shoji, H., Hattori, S., Koshimizu, H., Umemori, J., Toyama, K., Nakamura, H. K., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.38 · Cited by 173 · see citing works
Modelling trial-by-trial changes in the mismatch negativity
Lieder, F., Daunizeau, J., Garrido, M. I., Friston, K. J., & Stephan, K. E. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002911 · Cited by 168 · see citing works
A Dynamical Systems Hypothesis of Schizophrenia
Loh, M., Rolls, E. T., & Deco, G. (2007) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0030228 · Cited by 164 · see citing works
TAPAS: An Open-Source Software Package for Translational Neuromodeling and Computational Psychiatry
Frässle, S., Aponte, E. A., Bollmann, S., Brodersen, K. H., Do, C. T., Harrison, O. K., Harrison, S. J., Heinzle, J., Iglesias, S., Kasper, L., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.680811 · Cited by 169 · see citing works
Self-citation
Are hallucinations due to an imbalance between excitatory and inhibitory influences on the brain?
Jardri, R., Hugdahl, K., Hughes, M., Brunelin, J., Waters, F., Alderson-Day, B., Smailes, D., Sterzer, P., Corlett, P. R., Leptourgos, P., et al. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw075 · Cited by 157 · see citing works
A hemodynamic model for layered BOLD signals
Heinzle, J., Koopmans, P. J., den Ouden, H. E. M., Raman, S., & Stephan, K. E. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.10.025 · Cited by 144 · see citing works
Self-citation
Can Bayesian Theories of Autism Spectrum Disorder Help Improve Clinical Practice?
Haker, H., Schneebeli, M., & Stephan, K. E. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00107 · Cited by 130 · see citing works
Self-citation
RETRACTED: Impaired Visual Cortical Plasticity in Schizophrenia
Çavuş, I., Reinhart, R. M. G., Roach, B. J., Gueorguieva, R., Teyler, T. J., Clapp, W. C., Ford, J. M., Krystal, J. H., & Mathalon, D. H. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.013 · Cited by 130 · see citing works
Retracted
Brain Neuroplasticity in Healthy, Hyperactive and Psychotic Children: Insights from Neuroimaging
Rapoport, J. L., & Gogtay, N. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301553 · Cited by 132 · see citing works
Dysfunctional neural plasticity in patients with schizophrenia
Daskalakis, Z. J., Christensen, B. K., Fitzgerald, P. B., & Chen, R. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.4.378 · Cited by 130 · see citing works
Bayesian estimation of synaptic physiology from the spectral responses of neural masses
Moran, R. J., Stephan, K. E., Kiebel, S. J., Rombach, N., O'Connor, W. T., Murphy, K. J., Reilly, R. B., & Friston, K. J. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.01.025 · Cited by 126 · see citing works
Self-citation
Three-dimensional brain growth abnormalities in childhood-onset schizophrenia visualized by using tensor-based morphometry
Gogtay, N., Lu, A., Leow, A. D., Klunder, A. D., Lee, A. D., Chavez, A., Greenstein, D., Giedd, J. N., Toga, A. W., Rapoport, J. L., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806485105 · Cited by 125 · see citing works
Impaired top-down processes in schizophrenia: a DCM study of ERPs
Dima, D., Dietrich, D. E., Dillo, W., & Emrich, H. M. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.086 · Cited by 122 · see citing works
Mismatch negativity encoding of prediction errors predicts S-ketamine-induced cognitive impairments
Schmidt, A., Bachmann, R., Kometer, M., Csomor, P. A., Stephan, K. E., Seifritz, E., & Vollenweider, F. X. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.261 · Cited by 121 · see citing works
Effects of γ-Aminobutyric Acid–Modulating Drugs on Working Memory and Brain Function in Patients With Schizophrenia
Menzies, L., Ooi, C., Kamath, S., Suckling, J., McKenna, P., Fletcher, P., Bullmore, E., & Stephenson, C. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.2.156 · Cited by 120 · see citing works
Midbrain activation during pavlovian conditioning and delusional symptoms in schizophrenia
Romaniuk, L., Honey, G. D., King, J. R. L., Whalley, H. C., McIntosh, A. M., Levita, L., Hughes, M., Johnstone, E. C., Day, M., Lawrie, S. M., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.169 · Cited by 113 · see citing works
Linking inflammation, aberrant glutamate-dopamine interaction, and post-synaptic changes: translational relevance for schizophrenia and antipsychotic treatment: a systematic review
de Bartolomeis, A., Barone, A., Vellucci, L., Mazza, B., Austin, M. C., Iasevoli, F., & Ciccarelli, M. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02976-3 · Cited by 113 · see citing works
Modeling ketamine effects on synaptic plasticity during the mismatch negativity
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Authors: Stephan, K. E., Baldeweg, T., & Friston, K. J.
Affiliations: UCL Queen Square Institute of Neurology (GB)
Great Ormond Street Hospital (GB)
Corresponding author: Stephan, Klaas E.
ORCID: Stephan, Klaas E.
Baldeweg, Torsten
Friston, Karl J.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2006-05
Volume: 59
Issue: 10
Pages: 929-939
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2005.10.005
OpenAlex: W1998679999
Cited by: 841
References: 127
Citations by year: 2026: 20 · 2025: 21 · 2024: 27 · 2023: 18 · 2022: 30 · 2021: 40 · 2020: 41 · 2019: 47 · 2018: 29 · 2017: 55 · 2016: 45 · 2015: 64 · 2014: 55 · 2013: 69 · 2012: 51
FWCI: 5.96
Type: journal article
Language: en
Open access: green
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
UCL Discovery (University College London) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich)
Funders: Wellcome Trust (056750)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: schizophrenia, synaptic plasticity, brain dysconnectivity, neurotransmitter systems, perceptual learning, reinforcement learning, association fibers
MeSH terms: Acetylcholine, Brain, Brain Mapping, Contingent Negative Variation, Dopamine, Electroencephalography, Humans, Models, Neurological, Nerve Fibers, Nerve Net, Neuronal Plasticity, Schizophrenia, Synapses, N-Methylaspartate, Glutamic Acid

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Synaptic plasticity and dysconnection in schizophrenia

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