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REM Sleep Behavior Disorder: Clinical, Developmental, and Neuroscience Perspectives 16 Years After its Formal Identification in SLEEP
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“Neuromodulatory systems also create the conditions of muscle atonia during dreaming, without which dreams can be acted out by the body during sleep, a dangerous parasomnia called REM sleep behavior disorder.25”
From The overfitted brain: Dreams evolved to assist generalization (2021) · cites this paper as [25]
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THE RETICULAR FORMATION REVISITED
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“RBD was defined according to clinical ICSD-R minimal diagnostic criteria [1]: Limb or body movements associated with dream mentation (criterion B) in the presence of at least one of the following: harmful or potentially harmful sleep behaviors (criterion C1); dreams appear to be “acted out” (criterion C2); sleep behav…”
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“There is ample data from animal and human studies that dysfunction of brainstem structures and networks are likely involved, but which specific neuronal networks are involved in RBD pathogenesis has not yet been determined [1,3].”
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“However, certain barriers exist to using RBD as a marker of PD risk in large-scale studies including the finding that RBD appears to be a relatively rare disorder and a polysomnogram is required for diagnostic certainty.(57) It may be possible to use surveys of patients or bed partners to identify significant numbers…”
BackgroundManifestations of Parkinson disease differ in association with REM sleep behavior disorder
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“Understanding the mechanisms mediating REM sleep paralysis is clinically important because they could explain the nature of REM sleep disorders such as RBD, sleep paralysis and cataplexy/narcolepsy.”
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“RBD may also occur in multiple system atrophy and Lewy body dementia [9, 10].”
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“406 RBD is characterized by loss of the normal atonia 407 during REM sleep [64].”
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Rapid Eye Movement Sleep Parasomnias
Schenck, C. H., & Mahowald, M. W. (2005) · Neurologic Clinics · doi:10.1016/j.ncl.2005.06.002 · Cited by 121
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Violent behavior during sleep: Prevalence, comorbidity and consequences
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“The pathogenesis is thought to involve dysfunction of brainstem structures that regulate REM sleep muscle tone, such as the pedunculopontine nuclei, and anatomical connections with the limbic system, thalamus, and hypothalamus.(21-25) Rapid eye movement sleep behavior disorder has been recognized in disorders involvin…”
BackgroundSchenck, C. H., Lee, S., Bornemann, M. A. C., & Mahowald, M. W. (2009) · Journal of Forensic Sciences · doi:10.1111/j.1556-4029.2009.01163.x · Cited by 120
Self-citationMiner, B., & Kryger, M. H. (2020) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2020.02.016 · Cited by 120
REM sleep behavior disorder: From dreams to neurodegeneration
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Association between waking EEG slowing and REM sleep behavior disorder in PD without dementia
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Metadata
- Authors
- Schenck, C. H., & Mahowald, M. W.
- Affiliations
- Hennepin County Medical Center (US)
- ORCID
- Schenck, Carlos H.
- Venue
- SLEEP
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-01
- Volume
- 25
- Issue
- 2
- Pages
- 120-138
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- OpenAlex
- W2332602680
- Cited by
- 770
- References
- 159
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 22 · 2023: 16 · 2022: 34 · 2021: 32 · 2020: 42 · 2019: 30 · 2018: 41 · 2017: 36 · 2016: 32 · 2015: 30 · 2014: 38 · 2013: 47 · 2012: 40
- FWCI
- 11.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- SLEEP (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- REM sleep behavior disorder, clinical features, developmental aspects, neurobiology, sleep disorders, REM sleep
- MeSH terms
- Adolescent, Adult, Aged, Anticonvulsants, Chronic Disease, Clonazepam, Diagnosis, Differential, Electroencephalography, Female, HLA Antigens, Humans, Male, Middle Aged, Narcolepsy, Videotape Recording, Prevalence, Polysomnography, Parkinsonian Disorders, REM Sleep Parasomnias
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