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REM Sleep Behavior Disorder: Clinical, Developmental, and Neuroscience Perspectives 16 Years After its Formal Identification in SLEEP
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“Neuromodulatory systems also create the conditions of muscle atonia during dreaming, without which dreams can be acted out by the body during sleep, a dangerous parasomnia called REM sleep behavior disorder.25”
From The overfitted brain: Dreams evolved to assist generalization (2021) · cites this paper as [25]
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“The violent and injurious nature of RBD behaviors has been extensively reviewed elsewhere [ 20 ].”
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“48 Some cases of this condition can be viewed as primary parasomnias; others are secondary to neurological disease or drug treatment.”
BackgroundREM Sleep Behavior Disorder and Epileptic Phenomena: Clinical Aspects of the Comorbidity
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Self-citationSleep-related non epileptic motor disorders
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“[80, 86] recognized the episodes as associated with REM sleep, and as representing a new variety of parasomnia, which they defined REM sleep behavior disorder (RBD).”
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Diagnostic Delay in REM Sleep Behavior Disorder (RBD)
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“This might make them less likely to seek medical consultation (49, 50).”
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Rapid-eye-movement sleep behavior disorder secondary to acute aseptic limbic encephalitis
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“Sir, Rapid-eye-movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by complex motor activity associated with dreaming during REM sleep [1, 2].”
BackgroundViolent Parasomnias: Forensic Medicine Issues
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Reduced intraepidermal nerve fiber density in patients with REM sleep behavior disorder
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“Idiopathic RBD (iRBD) is considered to be one of the first features of neurodegenerative alpha-synucleinopathies such as Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA) [3e6].”
BackgroundInfluentialCurrent Concepts and Controversies in the Management of REM Sleep Behavior Disorder
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Impaired decision-making in idiopathic REM sleep behavior disorder
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“The resulting REM sleep behaviors range from brief twitches to complex movements, in which affected subjects may inflict injuries to themselves and/or their bedpartners [2].”
BackgroundRapid eye movement sleep behavior disorder: current knowledge and future directions
Schenck, C. H. (2013) · Sleep Medicine · doi:10.1016/j.sleep.2013.04.011 · Cited by 30
Self-citationNeuroscience of imagination and implications for human evolutionPreprint
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“When neurons in the brainstem that keep an animal from moving during REM sleep are disabled, many animals behave in a way that makes them look like they are acting out their dreams [108] very much like humans with REM sleep behavior disorder [109].”
BackgroundTimeline of Rapid Eye Movement Sleep Behavior Disorder in Overt Alpha‐Synucleinopathies
Stang, C. D., Mullan, A. F., Hajeb, M., Camerucci, E., Turcano, P., Martin, P., Mielke, M. M., Josephs, K. A., Bower, J. H., St Louis, E. K., et al. (2021) · Annals of Neurology · doi:10.1002/ana.25952 · Cited by 29
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Alexithymia Associated with Nightmare Distress in Idiopathic REM Sleep Behavior Disorder
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Complex Dream-Enacting Behavior in Sleepwalking
Pillmann, F. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318190772e · Cited by 28
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“In addition, medications that augment GABAergic activity, such as clonazepam and melatonin, are the most common and effective drugs for motor-related symptoms of RBD [139,140].”
BackgroundDream enactment behavior: review for the clinician
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“As regards RBD, it is known that its onset may precede or coincide with the first clinical manifestations of PD or DLB in most cases [29,30].”
BackgroundPeripheral Blood Inflammatory Cytokines in Idiopathic REM Sleep Behavior Disorder
Kim, R., Jun, J., Kim, H., Jung, K., Shin, Y., Yang, T., Kim, K. T., Kim, T., Byun, J., Sunwoo, J., et al. (2019) · Movement Disorders · doi:10.1002/mds.27841 · Cited by 27
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“(The differential diagnosis of dream-enacting behaviors has previously been discussed [ 22 ]).”
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“Other treatments such as melatonin and pramipexole have limited study evidence [Schmidt et al. 2006; Boeve et al. 2003].”
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“This can lead to dream enacting with potential injury to the patient or the bed partner (Schenck and Mahowald 2002).”
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Excessive Daytime Sleepiness in Major Dementia Syndromes
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“Night sleep behaviour disorder is a sleep disorder manifested by rapid eye movement, and problematic behaviours like dream enactment, talking, sleepwalking and atonia [34].”
BackgroundAutonomic dysfunction in isolated rapid eye movement sleep without atonia
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Sleep Abnormalities in MultipleSystem Atrophy
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Rapid Eye Movement Sleep during Early Life: A Comprehensive Narrative Review
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Sleep disorders in Wilson disease: A systematic review and meta-analysis
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“diseases [23, 28] and frequently represents a prodromal phase of a-synucleinopathies [16, 26].”
BackgroundFoldvary‐Schaefer, N., & Alsheikhtaha, Z. (2013) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000427210.98305.8f · Cited by 24
Härtner, L., Keil, T. W. M., Kreuzer, M., Fritz, E. M., Wenning, G. K., Stefanova, N., & Fenzl, T. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00252 · Cited by 24
“The first study to document the relationship of RBD and neurodegenerative diseases reported that in almost 40% of patients with isolated, idiopathic RBD, it was accompanied by α-synucleinopathy within a 10-year period (Schenck and Mahowald, 1996).”
MethodZhao, A., Li, Y., Niu, M., Li, G., Luo, N., Zhou, L., Kang, W., & Liu, J. (2020) · Journal of Parkinson s Disease · doi:10.3233/jpd-201912 · Cited by 23
Disrupted functional connectivity in PD with probable RBD and its cognitive correlates
Oltra, J., Campabadal, A., Segura, B., Uribe, C., Martı́, M. J., Compta, Y., Valldeoriola, F., Bargalló, N., Iranzo, Á., & Junqué, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-03751-5 · Cited by 23
Dijkstra, F., Volder, I. D., Viaene, M. K., Cras, P. P., & Crosiers, D. (2022) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-022-01226-2 · Cited by 23
Frenette, E. (2010) · Medical Clinics of North America · doi:10.1016/j.mcna.2010.02.010 · Cited by 23
Kunz, D., & Bes, F. (2017) · Neuropsychobiology · doi:10.1159/000488893 · Cited by 23
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Metadata
- Authors
- Schenck, C. H., & Mahowald, M. W.
- Affiliations
- Hennepin County Medical Center (US)
- ORCID
- Schenck, Carlos H.
- Venue
- SLEEP
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-01
- Volume
- 25
- Issue
- 2
- Pages
- 120-138
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- OpenAlex
- W2332602680
- Cited by
- 770
- References
- 159
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 22 · 2023: 16 · 2022: 34 · 2021: 32 · 2020: 42 · 2019: 30 · 2018: 41 · 2017: 36 · 2016: 32 · 2015: 30 · 2014: 38 · 2013: 47 · 2012: 40
- FWCI
- 11.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- SLEEP (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- REM sleep behavior disorder, clinical features, developmental aspects, neurobiology, sleep disorders, REM sleep
- MeSH terms
- Adolescent, Adult, Aged, Anticonvulsants, Chronic Disease, Clonazepam, Diagnosis, Differential, Electroencephalography, Female, HLA Antigens, Humans, Male, Middle Aged, Narcolepsy, Videotape Recording, Prevalence, Polysomnography, Parkinsonian Disorders, REM Sleep Parasomnias
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