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Cited by 25Sleep and Wakefulness ResearchSleep and related disordersSleep and Work-Related Fatigue

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EEG Sleep Spectra in Older Adults Across All Circadian Phases During NREM Sleep

Open access
Münch, Mirjam, Silva, Edward J., Ronda, Joseph M., Czeisler, Charles A., Duffy, Jeanne F.·2010·Sleep
DOI 10.1093/sleep/33.3.389PMC PMC2831434
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Abstract

STUDY OBJECTIVES: Healthy aging is associated with changes in sleep-wake regulation, and those changes often lead to problems sleeping, both during the night and during daytime. We aimed to examine the electroencephalographic (EEG) sleep spectra during non-rapid eye movement (NREM) sleep when sleep was scheduled at all times of day. DESIGN/INTERVENTIONS: After three 24-h baseline (BL) days, participants were scheduled to live on 20-hour "days" consisting of 6.7 hours of bed rest and 13.3 hours of wakefulness for 12 consecutive days (forced desynchrony, FD). The EEG was recorded from a central derivation during all scheduled sleep episodes, with subsequent visual scoring and spectral analysis. SETTING: Intensive Physiological Monitoring Unit of the Brigham & Women's Hospital General Clinical Research Center. PARTICIPANTS: Twenty-four healthy older subjects (64.2 +/- 6.3 yr; 13 women, 11 men) MEASUREMENTS AND RESULTS: Compared with BL nights, EEG activity in the slow wave (0.5 to 5.25 Hz), theta (6 to 6.25 and 7 Hz), alpha (10 to 11.25 Hz), and high spindle range (14.5 to 15.5 Hz) was significantly greater during FD, when subjects slept across many times of day and night. During FD, there was a significant interaction between homeostatic and circadian factors, such that EEG delta activity (0.5 to 1.5 Hz) was higher in the biological morning/early afternoon than at other times. EEG activity was significantly increased in almost all frequency ranges (0.5 to 21 Hz) during the biological day, as compared with the biological night, except for the lower EEG spindle range (12.25 to 14 Hz). Overall, EEG beta activity was positively correlated with wakefulness and negatively correlated with total sleep time. CONCLUSION: Our findings provide some new evidence for the underlying mechanisms that contribute to age-related difficulties in sleep consolidation, especially when sleep occurs during the daytime.

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Crossref · 10.1093/sleep/33.3.389

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  • Dream features, as well as quantitative features of sleep, undergo the influence of circadian rhythms.

    “Dream features, as well as quantitative features of sleep, undergo the influence of circadian rhythms.52–57”

    From Spotlight on dream recall: the ages of dreams (2018) · cites this paper as [57]

    The Sleep Stages section (page unavailable) reports significant circadian variation in wakefulness and total sleep time, supporting the claim about quantitative sleep features. The paper examines sleep stages and EEG spectra in older adults but does not address dream features, so it does not support that part of the sentence. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • A reduced delta activity (slow-wave activity) and SWS, conjointly with an increased beta activity, have been observed in elderly compared to younger subjects.

    “Additionally, a reduced delta activity (ie, slow-wave activity) and SWS,56,123,130 conjointly with an increased beta activity, have been observed in elderly compared to younger subjects.57”

    From Spotlight on dream recall: the ages of dreams (2018) · cites this paper as [57]

    Citation 57 is attached to the increased-beta-activity comparison, not the preceding delta-activity and SWS claims. In the section on circadian and homeostatic effects, the paper reports a prior finding of higher nighttime beta activity in middle-aged than young subjects and describes increased beta activity in its own older subjects during daytime sleep. It does not report a direct beta-activity comparison between elderly and younger subjects. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • The influence of circadian and ultradian factors on dream features and recall rates could be a possible explanation for the inconsistent findings in EEG correlates of dream recall.

    “The influence of circadian and ultradian factors on dream features and recall rates52–57 could be a possible explanation for the inconsistent findings in EEG correlates of dream recall.”

    From Spotlight on dream recall: the ages of dreams (2018) · cites this paper as [57]

    The Discussion and Conclusion describe circadian and homeostatic effects on NREM sleep stages and EEG spectra in older adults. Searches for dream features, dream recall rates, and ultradian effects found no passage addressing the influence attributed to this source; the sentence’s proposed explanation for inconsistent EEG findings is the citing authors’ own framing. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

  • Different time of collection of dream report could lead to different qualitative features in dream recall, due to a direct influence of circadian and homeostatic influencing factors.

    “Moreover, different time of collection of dream report (ie, in the middle of the night compared to the end or the beginning) could lead to different qualitative features in dream recall, due to a direct influence of circadian and homeostatic influencing factors.52–57”

    From Spotlight on dream recall: the ages of dreams (2018) · cites this paper as [57]

    The Sleep Stages and Separation of Circadian and homeostatic Effects sections report effects of circadian phase and time within sleep on sleep stages and NREM EEG spectra (page numbers unavailable). The copy does not address dream-report collection, qualitative features of dream recall, or whether those features change with collection time; searches for dream reports and recall found no relevant passage. (LLM, conf=0.76)

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Metadata

Authors
Münch, M., Silva, E. J., Ronda, J. M., Czeisler, C. A., & Duffy, J. F.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Duffy, Jeanne F.
ORCID
Venue
Sleep
Publisher
Oxford University Press (OUP)
Published
2010-03
Volume
33
Issue
3
Pages
389-401
ISSN
  • 0161-8105 (ISSN-L)
  • 1550-9109
DOI
10.1093/sleep/33.3.389
PMC
PMC2831434
OpenAlex
W87142834
Cited by
25
References
8
Citations by year
2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 1
FWCI
0.97
Type
journal article
Language
en
Open access
Locations
  • SLEEP (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (P01AG009975, P01 AG-09975)
  • National Center for Research Resources (M01 RR 02635, M01RR002635)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
NREM sleep, older adults, healthy aging, forced desynchrony, circadian phase, homeostatic sleep drive, delta oscillations, sleep spindles, theta activity, alpha activity, beta activity, daytime sleep, sleep consolidation, sleep-wake regulation
MeSH terms
Aged, Aging, Circadian Rhythm, Electroencephalography, Female, Homeostasis, Humans, Male, Middle Aged, Reference Values, Signal Processing, Computer-Assisted, Sleep Stages, Wakefulness

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