Activation of ventrolateral preoptic neurons during sleep
Abstract
The rostral hypothalamus and adjacent basal forebrain participate in the generation of sleep, but the neuronal circuitry involved in this process remains poorly characterized. Immunocytochemistry was used to identify the FOS protein, an immediate-early gene product, in a group of ventrolateral preoptic neurons that is specifically activated during sleep. The retrograde tracer cholera toxin B, in combination with FOS immunocytochemistry, was used to show that sleep-activated ventrolateral preoptic neurons innervate the tuberomammillary nucleus, a posterior hypothalamic cell group thought to participate in the modulation of arousal. This monosynaptic pathway in the hypothalamus may play a key role in determining sleep-wake states.
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The VLPO contains sleep-active neurons.
“the ventrolateral preoptic nucleus (VLPO) contains neurons that are sleep-active [96, 97]”
From The Biology of General Anesthesia from Paramecium to Primate (2019) · cites this paper as [96]
Cites
The regulation and function of c-fos and other immediate early genes in the nervous system
Sheng, M., & Greenberg, M. E. (1990) · Neuron · doi:10.1016/0896-6273(90)90106-p · Cited by 2,432 · see citing works
Expression of c- <i>fos</i> Protein in Brain: Metabolic Mapping at the Cellular Level
Sagar, S. M., Sharp, F. R., & Curran, T. (1988) · Science · doi:10.1126/science.3131879 · Cited by 1,925 · see citing works
The use of c-fos as a metabolic marker in neuronal pathway tracing
Dragunow, M., & Faull, R. (1989) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(89)90150-7 · Cited by 1,416 · see citing works
Histaminergic transmission in the mammalian brain
Schwartz, J., Arrang, J., Garbarg, M., Pollard, H., & Ruat, M. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.1.1 · Cited by 945 · see citing works
Histamine-containing neurons in the rat hypothalamus.
Panula, P. A. J., Yang, H., & Costa, E. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.8.2572 · Cited by 738 · see citing works
c-Fos and Related Immediate Early Gene Products as Markers of Activity in Neuroendocrine Systems
Hoffman, G. E., Smith, M. S., & Verbalis, J. G. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1006 · Cited by 715 · see citing works
SLEEP AS A PROBLEM OF LOCALIZATION
von Economo, C. (1930) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-193003000-00001 · Cited by 687 · see citing works
HYPOTHALAMIC REGULATION OF SLEEP IN RATS. AN EXPERIMENTAL STUDY
Nauta, W. J. H. (1946) · Journal of Neurophysiology · doi:10.1152/jn.1946.9.4.285 · Cited by 668 · see citing works
Sleep Suppression after Basal Forebrain Lesions in the Cat
McGinty, D., & Sterman, M. B. (1968) · Science · doi:10.1126/science.160.3833.1253 · Cited by 430 · see citing works
Evidence for histaminergic arousal mechanisms in the hypothalamus of cat
Lin, J., Sakai, K., & Jouvet, M. (1988) · Neuropharmacology · doi:10.1016/0028-3908(88)90159-1 · Cited by 330 · see citing works
Lin, J., Sakai, K., Vanni-Mercier, G., & Jouvet, M. (1989) · Brain Research · doi:10.1016/0006-8993(89)91623-5 · Cited by 318 · see citing works
Sleep-related neuronal discharge in the basal forebrain of cats
Szymusiak, R. S., & McGinty, D. (1986) · Brain Research · doi:10.1016/0006-8993(86)91107-8 · Cited by 259 · see citing works
Forebrain inhibitory mechanisms: Cortical synchronization induced by basal forebrain stimulation
Sterman, M. B., & Clemente, C. (1962) · Experimental Neurology · doi:10.1016/0014-4886(62)90080-8 · Cited by 244 · see citing works
Sallanon, M. M., Denoyer, M., Kitahama, K., Aubert, C., Gay, N., & Jouvet, M. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90289-3 · Cited by 235 · see citing works
Watanabe, T., Taguchi, Y., Hayashi, H., et al. (1983) · Neuroscience Letters · doi:10.1016/0304-3940(83)90308-7 · Cited by 218 · see citing works
Gritti, I., Mainville, L., & Jones, B. E. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903390206 · Cited by 179 · see citing works
Prostaglandin D2 induces sleep when microinjected into the preoptic area of conscious rats
Ueno, R., Ishikawa, Y., Nakayama, T., & Hayaishi, O. (1982) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(82)91760-0 · Cited by 172 · see citing works
Involvement of histamine in the control of the waking state
Monti, J. M. (1993) · Life Sciences · doi:10.1016/0024-3205(93)90592-q · Cited by 162 · see citing works
Sleep suppression following kainic acid-induced lesions of the basal forebrain
Szymusiak, R. S., & McGinty, D. (1986) · Experimental Neurology · doi:10.1016/0014-4886(86)90240-2 · Cited by 153 · see citing works
Senba, E., Daddona, P. E., Watanabe, T., Wu, J., & Nagy, J. I. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-12-03393.1985 · Cited by 152 · see citing works
Matsumura, H., Nakajima, T., Osaka, T., Satoh, S., Kawase, K., Kubo, E., Kantha, S. S., Kasahara, K., & Hayaishi, O. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.25.11998 · Cited by 143 · see citing works
Pompeiano, M., Cirelli, C., & Tononi, G. (1994) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1994.tb00111.x · Cited by 142 · see citing works
[Specific neurons for wakefulness in the posterior hypothalamus in the cat].
Vanni-Mercier, G., Sakai, K., & Jouvet, M. (1984) · PubMed · Cited by 135 · see citing works
Spontaneous activity of single neurones in the hypothalamus of rabbits during sleep and waking
Findlay, A. L. R., & Hayward, J. N. (1969) · The Journal of Physiology · doi:10.1113/jphysiol.1969.sp008753 · Cited by 119 · see citing works
Relaxation and sleep induced by warming of preoptic region and anterior hypothalamus in cats
Roberts, W. W., & Robinson, T. C. (1969) · Experimental Neurology · doi:10.1016/0014-4886(69)90051-x · Cited by 115 · see citing works
Localization of neuronal histamine in rat brain
Wilcox, B. J., & Seybold, V. S. (1982) · Neuroscience Letters · doi:10.1016/0304-3940(82)90337-8 · Cited by 107 · see citing works
Preoptic area unit activity during sleep and wakefulness in the cat
Kaitin, K. I. (1984) · Experimental Neurology · doi:10.1016/s0014-4886(84)90103-1 · Cited by 99 · see citing works
Circadian rhythm in c-fos-like immunoreactivity in the rat brain
Kononen, J., Koıstınaho, J., & Alho, H. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90179-d · Cited by 94 · see citing works
McGinty, D., Szymusiak, R. S., & Thomson, D. (1994) · Brain Research · doi:10.1016/0006-8993(94)91506-7 · Cited by 74 · see citing works
Effect of a forebrain lesion on the polycyclic sleep-wake cycle and sleep-wake patterns in the cat
Lucas, E. A., & Sterman, M. B. (1975) · Experimental Neurology · doi:10.1016/0014-4886(75)90142-9 · Cited by 71 · see citing works
Elmquist, J. K., Ackermann, M. R., Register, K. B., Rimler, R. B., Ross, L., & Jacobson, C. (1993) · Endocrinology · doi:10.1210/endo.133.6.8243337 · Cited by 70 · see citing works
Firing properties of cat basal forebrain neurones during sleep-wakefulness cycle
Détári, L., Juhász, G. D., & Kukorelli, T. (1984) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(84)90062-2 · Cited by 67 · see citing works
GABA‐like immunoreactivity in the tuberomammillary nucleus: An electron microscopic study in the rat
Ericson, H., Köhler, C., & Blomqvist, A. G. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903050309 · Cited by 58 · see citing works
Krilowicz, B. L., Szymusiak, R. S., & McGinty, D. (1994) · Brain Research · doi:10.1016/0006-8993(94)90507-x · Cited by 55 · see citing works
Shiromani, P. J., Magner, M., Winston, S. H., & Charness, M. E. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00242-7 · Cited by 47 · see citing works
Self-citationThe pendulum technique for paradoxical sleep deprivation in rats
Hulzen, Z. J. M. V., & Coenen, A. M. L. (1980) · Physiology & Behavior · doi:10.1016/0031-9384(80)90298-x · Cited by 41 · see citing works
Sleep-waking discharge of neurons in the posterior lateral hypothalamic area of cats
Szymusiak, R., Iriye, T., & McGinty, D. (1989) · Brain Research Bulletin · doi:10.1016/0361-9230(89)90169-x · Cited by 41 · see citing works
Activity of preoptic neurons during synchronization and desynchronization
Mallick, B. N., Chhina, G. S., Sundaram, K. R., et al. (1983) · Experimental Neurology · doi:10.1016/0014-4886(83)90328-x · Cited by 40 · see citing works
Grassi-Zucconi, G., Giuditta, A., Mandile, P., Chen, S., Vescia, S., & Bentivoglio, M. (1994) · Journal of Physiology-Paris · doi:10.1016/0928-4257(94)90096-5 · Cited by 37 · see citing works
Fos-like immunoreactivity in the rat brain in spontaneous wakefulness and sleep.
Cirelli, C., Pompeiano, M., & Tononi, G. (1993) · PubMed · Cited by 36 · see citing works
Enhancement of sleep by microinjection of triazolam into the medial preoptic area
Mendelson, W. B. (1989) · Neuropsychopharmacology · doi:10.1016/0893-133x(89)90008-0 · Cited by 36 · see citing works
García-Arrarás, J., & Pappenheimer, J. R. (1983) · Journal of Neurophysiology · doi:10.1152/jn.1983.49.2.528 · Cited by 29 · see citing works
Koyama, Y., & Hayaishi, O. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90278-x · Cited by 28 · see citing works
Szymusiak, R. S., & McGinty, D. (1989) · Brain Research · doi:10.1016/0006-8993(89)91116-5 · Cited by 26 · see citing works
Increase of multiple unit activity during slow wave sleep in the cat preoptic area.
Ogawa, Y., & Kawamura, H. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90108-6 · Cited by 25 · see citing works
Behavioral thermoregulation in rats during hyperthermia induced by lysergic acid diethylamide
Murakami, N., Sakai, Y., & Ooki, S. (1980) · Neuroscience Letters · doi:10.1016/0304-3940(80)90242-6 · Cited by 9 · see citing works
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Hobson, J. A., Pace-Schott, E. F., & Stickgold, R. (2000) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00003976 · Cited by 985 · see citing works
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Dew, M. A., Hoch, C. C., Buysse, D. J., Monk, T. H., Begley, A. E., Houck, P. R., Hall, M., Kupfer, D. J., & Reynolds, C. F. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000039756.23250.7c · Cited by 587 · see citing works
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Xu, M., Chung, S., Zhang, S., Zhong, P., Ma, C., Chang, W.-C., Weissbourd, B., Sakai, N., Luo, L., Nishino, S., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4143 · Cited by 514 · see citing works
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VanSomeren, E. J. W. (2000) · Chronobiology International · doi:10.1081/cbi-100101050 · Cited by 329 · see citing works
Circadian regulation of sleep in mammals: Role of the suprachiasmatic nucleus
Mistlberger, R. E. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.01.005 · Cited by 318 · see citing works
Identification of preoptic sleep neurons using retrograde labelling and gene profiling
Chung, S., Weber, F., Zhong, P., Tan, C. L., Nguyen, T. N., Beier, K. T., Hörmann, N., Chang, W.-C., Zhang, Z., Do, J. P., et al. (2017) · Nature · doi:10.1038/nature22350 · Cited by 317 · see citing works
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Prostaglandin D2 and sleep/wake regulation
Urade, Y., & Hayaishi, O. (2011) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2011.08.003 · Cited by 200 · see citing works
Dynamic coupling between the central and autonomic nervous systems during sleep: a review
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McKinley, M. J., Yao, S. T., Uschakov, A., McAllen, R. M., Rundgren, M., & Martelli, D. (2015) · Acta Physiologica · doi:10.1111/apha.12487 · Cited by 180 · see citing works
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Self-citationMoore, J. T., Chen, J., Han, B., Meng, Q. C., Veasey, S. C., Beck, S. G., & Kelz, M. B. (2012) · Current Biology · doi:10.1016/j.cub.2012.08.042 · Cited by 171 · see citing works
Sleep, its regulation and possible mechanisms of sleep disturbances
Porkka‐Heiskanen, T., Zitting, K. ‐., & Wigren, H. ‐. (2013) · Acta Physiologica · doi:10.1111/apha.12134 · Cited by 157 · see citing works
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The Biology of General Anesthesia from Paramecium to Primate
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Alam, M. N., McGinty, D., Bashir, T., Kumar, S., Imeri, L., Opp, M. R., & Szymusiak, R. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03469.x · Cited by 108 · see citing works
Sleep propensity is modulated by circadian and behavior-induced changes in cutaneous temperature
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Daytime melatonin and light independently affect human alertness and body temperature
Lok, R., van Koningsveld, M. J., Gordijn, M. C. M., Beersma, D. G. M., & Hut, R. A. (2019) · Journal of Pineal Research · doi:10.1111/jpi.12583 · Cited by 81 · see citing works
The retinal iprgc-preoptic circuit mediates the acute effect of light on sleep
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What keeps us awake?–the role of clocks and hourglasses, light, and melatonin
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Self-citationFear conditioning increases NREM sleep.
Hellman, K., & Abel, T. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.2.310 · Cited by 62 · see citing works
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Self-citationPropofol facilitates glutamatergic transmission to neurons of the ventrolateral preoptic nucleus
Li, K. Y., Guan, Y.-Z., Krnjević, K., & Ye, J. H. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181bf1d79 · Cited by 45 · see citing works
Siclari, F., & Tononi, G. (2016) · The Neurology of Conciousness · doi:10.1016/b978-0-12-800948-2.00007-8 · Cited by 27 · see citing works
Tononi, G. (2009) · The Neurology of Consciousness · doi:10.1016/b978-0-12-374168-4.00008-3 · Cited by 16 · see citing works
Anatomy of the Mammalian Circadian System
Gooley, J. J., & Saper, C. B. (2017) · Principles and Practice of Sleep Medicine · doi:10.1016/b978-0-323-24288-2.00033-7 · Cited by 9 · see citing works
Self-citation
- Authors
- Sherin, J. E., Shiromani, P. J., McCarley, R. W., & Saper, C. B.
- Affiliations
- Harvard University (US)
- Corresponding author
- Saper, C. B.
- Venue
- Science
- Published
- 1996-01-12
- Volume
- 271
- Issue
- 5246
- Pages
- 216-219
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1989776859
- Cited by
- 1,111
- References
- 46
- Citations by year
- 2026: 21 · 2025: 24 · 2024: 25 · 2023: 33 · 2022: 30 · 2021: 43 · 2020: 24 · 2019: 48 · 2018: 54 · 2017: 46 · 2016: 42 · 2015: 42 · 2014: 31 · 2013: 43 · 2012: 53
- FWCI
- 16.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns022835-11, 1f31mh010709-01)
- National Institute of Mental Health (MH10709)
- National Institute of Neurological Disorders and Stroke (NS30140, NS-22835, R01NS030140)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- ventrolateral preoptic nucleus, sleep, FOS, immediate early genes, tuberomammillary nucleus, hypothalamus, basal forebrain, sleep-wake regulation, arousal, monosynaptic pathway, neuronal activation
- MeSH terms
- Animals, Brain Chemistry, Cholera Toxin, Circadian Rhythm, Immunohistochemistry, Mammillary Bodies, Neural Pathways, Neurons, Preoptic Area, Sleep, Proto-Oncogene Proteins c-fos, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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