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Abnormal Liver Development and Resistance to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Toxicity in Mice Carrying a Mutation in the DNA-Binding Domain of the Aryl Hydrocarbon Receptor

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Bunger, Maureen K., Glover, Edward, Moran, Susan M., Walisser, Jacqueline A., Lahvis, Garet P., Hsu, Erin L., Bradfield, Christopher A.·2008·Toxicological Sciences

DOI 10.1093/toxsci/kfn149PMC PMC2563146

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Abstract

The aryl hydrocarbon receptor (AHR) is known for its role in the adaptive and toxic responses to a large number of environmental contaminants, as well as its role in hepatovascular development. The classical AHR pathway involves ligand binding, nuclear translocation, heterodimerization with the AHR nuclear translocator (ARNT), and binding of the heterodimer to dioxin response elements (DREs), thereby modulating the transcription of an array of genes. The AHR has also been implicated in signaling events independent of nuclear localization and DNA binding, and it has been suggested that such pathways may play important roles in the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Here, we report the generation of a mouse model that expresses an AHR protein capable of ligand binding, interactions with chaperone proteins, functional heterodimerization with ARNT, and nuclear translocation, but is unable to bind DREs. Using this model, we provide evidence that DNA binding is required AHR-mediated liver development, as Ahr(dbd/dbd) mice exhibit a patent ductus venosus, similar to what is seen in Ahr(-/-) mice. Furthermore, Ahr(dbd/dbd) mice are resistant to TCDD-induced toxicity for all endpoints tested. These data suggest that DNA binding is necessary for AHR-mediated developmental and toxic signaling.

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2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity
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Authors: Bunger, M. K., Glover, E., Moran, S. M., Walisser, J. A., Lahvis, G. P., Hsu, E. L., & Bradfield, C. A.
Affiliations: University of Wisconsin–Madison (US)
ORCID: Lahvis, Garet P.
Hsu, Erin L.
Bradfield, Christopher A.
Venue: Toxicological Sciences
Publisher: Oxford University Press (OUP)
Published: 2008-07-27
Volume: 106
Issue: 1
Pages: 83-92
ISSN: 1096-0929 (ISSN-L)
1096-6080
DOI: 10.1093/toxsci/kfn149
PMC: PMC2563146
OpenAlex: W2148529156
Cited by: 139
References: 40
Citations by year: 2026: 3 · 2025: 4 · 2024: 1 · 2023: 5 · 2022: 4 · 2021: 9 · 2020: 3 · 2019: 7 · 2018: 4 · 2017: 9 · 2016: 6 · 2015: 4 · 2014: 12 · 2013: 12 · 2012: 7
FWCI: 11.29
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Toxicological Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (CA014520)
National Cancer Institute (T32CA009135, P01CA022484, P30CA014520)
National Institute of Environmental Health Sciences (R01ES013566, F32ES005877, R01-ES-013566-01)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords: aryl hydrocarbon receptor, 2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD toxicity, liver development, patent ductus venosus, dioxin response element, mouse model
MeSH terms: Polychlorinated Dibenzodioxins, Animals, Carcinogens, Environmental, Carrier Proteins, Cleft Palate, DNA, Fetal Proteins, Hydronephrosis, Liver, Male, Mice, Mutant Strains, Microtubule-Associated Proteins, Portal Vein, Thymus Gland, Transfection, Signal Transduction, 3T3 Cells, Receptors, Aryl Hydrocarbon, Gene Expression Regulation, Developmental, Cytochrome P-450 CYP1A1, Response Elements, Mice, Basic Helix-Loop-Helix Proteins, Basic Helix-Loop-Helix Transcription Factors

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Abnormal Liver Development and Resistance to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Toxicity in Mice Carrying a Mutation in the DNA-Binding Domain of the Aryl Hydrocarbon Receptor

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