Cited by 169Endometriosis Research and TreatmentReproductive System and PregnancyEstrogen and related hormone effects

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Steroidogenic Enzyme and Key Decidualization Marker Dysregulation in Endometrial Stromal Cells from Women with Versus Without Endometriosis1

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Aghajanova, L., Hamilton, A., Kwintkiewicz, J., Vo, K.C., Giudice, L.C.·2009·Biology of Reproduction

DOI 10.1095/biolreprod.108.070300PMC PMC2704986

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Abstract

Identification of mechanisms underlying endometriosis pathogenesis will facilitate understanding and treatment of infertility and pain associated with this disorder. Herein, we investigated the expression of steroidogenic pathway enzymes and key decidualization biomarkers in endometrial tissue and in eutopic endometrial stromal fibroblasts (hESFs) from women with vs. those without endometriosis, and subsequently treated in vitro with 8-bromo-cAMP (8-Br-cAMP) or progesterone (P4). Real-time quantitative PCR, immunohistochemistry, ELISA, and radiometric aromatase activity assay were used. The results demonstrate significantly increased (14.5-fold; P=0.037) expression of aromatase in eutopic endometrium of women with disease. In 8-Br-cAMP-treated hESF from eutopic endometrium of women with endometriosis, the balance in estradiol (E2) and P4 biosynthetic and metabolizing enzymes is disturbed (decreased HSD3B1 and HSD17B2, and increased HSD17B1 and aromatase), with the equilibrium being shifted towards an E2-enriched milieu. However, hESF from the same group of women treated with P4 did not demonstrate such responsiveness. Lower expression of IGFBP1 and prolactin mRNA and protein was observed in hESF from women with vs. those without endometriosis in response to 8-Br-cAMP, but not P4, suggesting a blunted response of these decidual biomarkers to activation of the PKA pathway in eutopic endometrium in women with disease. The dichotomy of 8-Br-cAMP regulation of select steroidogenic enzymes leading to an enriched E2 milieu within the endometrium and a blunted response of decidual biomarkers to this decidualizing agent of hESF from women with endometriosis suggests resistance to full decidualization of the stromal fibroblasts and mechanisms underlying implantation failure and the pathophysiology of this disorder.

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Revised American Fertility Society Classification of Endometriosis: 1985
(1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48430-x · Cited by 1,803
Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones
Payne, A. H., & Hales, D. B. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0030 · Cited by 1,766
Physiological Action of Progesterone in Target Tissues
Graham, J. D., & Clarke, C. L. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.4.0308 · Cited by 1,007
Gene Expression Analysis of Endometrium Reveals Progesterone Resistance and Candidate Susceptibility Genes in Women with Endometriosis
Burney, R. O., Talbi, S., Hamilton, A. E., Vo, K. C., Nyegaard, M., Nezhat, C. R., Lessey, B. A., & Giudice, L. C. (2007) · Endocrinology · doi:10.1210/en.2006-1692 · Cited by 735
Self-citation
Expression Profiling of Endometrium from Women with Endometriosis Reveals Candidate Genes for Disease-Based Implantation Failure and Infertility
Kao, L. C., Germeyer, A., Tulac, S., Lobo, S., Yang, J. P., Taylor, R. N., Osteen, K., Lessey, B. A., & Giudice, L. C. (2003) · Endocrinology · doi:10.1210/en.2003-0043 · Cited by 696
Self-citation
Establishment and Characterization of a Steroidogenic Human Granulosa-Like Tumor Cell Line, KGN, That Expresses Functional Follicle-Stimulating Hormone Receptor
Nishi, Y., Yanase, T., Yi-ming, M., Oba, K., Ichino, I., Saito, M., Nomura, M., Mukasa, C., Okabe, T., Goto, K., et al. (2001) · Endocrinology · doi:10.1210/endo.142.1.7862 · Cited by 596
Molecular Phenotyping of Human Endometrium Distinguishes Menstrual Cycle Phases and Underlying Biological Processes in Normo-Ovulatory Women
Talbi, S., Hamilton, A. E., Vo, K. C., Tulac, S., Overgaard, M. T., Dosiou, C., Le Shay, N., Nezhat, C. N., Kempson, R., Lessey, B. A., et al. (2006) · Endocrinology · doi:10.1210/en.2005-1076 · Cited by 589
Self-citation
Aromatase expression in endometriosis.
Noble, L. S., Simpson, E. R., Johns, A., & Bulun, S. E. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.1.8550748 · Cited by 566 · cited 1×
“expression in eutopic endometrium of women without endometriosis has been reported [43, 55, 71], and was confirmed in the current study using sensitive quantitative RT-PCR and endometrial samples from women without disease who had indications for surgical procedures that included uterine prolapse, pelvic pain, and a n…”
Neurosteroids: biochemistry and clinical significance
Mellon, S. H., & Griffin, L. D. (2002) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(01)00503-3 · Cited by 538
Cyclic AMP and progesterone receptor cross-talk in human endometrium: a decidualizing affair
Gellersen, B., & Brosens, J. J. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1780357 · Cited by 442
Progesterone resistance in endometriosis: link to failure to metabolize estradiol.
Bulun, S. E., Cheng, Y.-H., Yin, P., Imir, G., Utsunomiya, H., Attar, E., Innes, J., & Julie Kim, J. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.11.041 · Cited by 397
Aromatization of Androstenedione by Human Adipose Tissue Stromal Cells in Monolayer Culture*
Ackerman, G. E., Smith, M. E., Mendelson, C. R., MacDonald, P. C., & Simpson, E. R. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-2-412 · Cited by 389
Endometriosis: cost estimates and methodological perspective
Simoens, S., Hummelshoj, L., & D'Hooghe, T. (2007) · Human Reproduction Update · doi:10.1093/humupd/dmm010 · Cited by 357
Promoter Methylation Regulates Estrogen Receptor 2 in Human Endometrium and Endometriosis1
Xue, Q., Lin, Z., Cheng, Y.-H., Huang, C.-C., Marsh, E., Yin, P., Milad, M. P., Confino, E., Reierstad, S., Innes, J., et al. (2007) · Biology of Reproduction · doi:10.1095/biolreprod.107.061804 · Cited by 346
Deficient 17β-Hydroxysteroid Dehydrogenase Type 2 Expression in Endometriosis: Failure to Metabolize 17β-Estradiol1
Zeitoun, K., Takayama, K., Sasano, H., Suzuki, T., Moghrabi, N., Andersson, S., Johns, A., Meng, L., Putman, M., Carr, B., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.12.5301 · Cited by 308
Expression of Aromatase Cytochrome P450 Protein and Messenger Ribonucleic Acid in Human Endometriotic and Adenomyotic Tissues but not in Normal Endometrium1
Kitawaki, J., Noguchi, T., Amatsu, T., Maeda, K., Tsukamoto, K., Yamamoto, T., Fushiki, S., Osawa, Y., & Honjo, H. (1997) · Biology of Reproduction · doi:10.1095/biolreprod57.3.514 · Cited by 305
17beta-hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes
Peltoketo, H., Luu-The, V, Simard, J., & Adamski, J. (1999) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0230001 · Cited by 302
Prostaglandin E2 Stimulates Aromatase Expression in Endometriosis-Derived Stromal Cells
Noble, L. S. (1997) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.2.600 · Cited by 301
Decidual Stromal Cell Response to Paracrine Signals from the Trophoblast: Amplification of Immune and Angiogenic Modulators1
Hess, A. P., Hamilton, A. E., Talbi, S., Dosiou, C., Nyegaard, M., Nayak, N. R., Genbecev-Krtolica, O., Mavrogianis, P. A., Ferrer, K., Krüssel, J.-S., et al. (2006) · Biology of Reproduction · doi:10.1095/biolreprod.106.054791 · Cited by 291
Self-citation
Discovery of New Inducible Genes inin vitroDecidualized Human Endometrial Stromal Cells Using Microarray Technology
Popovici, R. M., Kao, L.-C., & Giudice, L. C. (2000) · Endocrinology · doi:10.1210/endo.141.9.7789 · Cited by 275
Self-citation
Treatment of severe postmenopausal endometriosis with an aromatase inhibitor
Takayama, K., Zeitoun, K., Gunby, R. T., Sasano, H., Carr, B. R., & Bulun, S. E. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00022-3 · Cited by 270
Stromal cells from endometriotic lesions and endometrium from women with endometriosis have reduced decidualization capacity
Klemmt, P. A. B., Carver, J. G., Kennedy, S., Koninckx, P. R., & Mardon, H. J. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.08.046 · Cited by 256
Hormonal regulation of human endometrial stromal cells in culture: an in vitro model for decidualization
Irwin, J. C., Kirk, D., King, R. J. B., Quigley, M. M., & Gwatkin, R. B. L. (1989) · Fertility and Sterility · doi:10.1016/s0015-0282(16)61028-2 · Cited by 248
Decidualization of the human endometrial stromal cell: an enigmatic transformation
Dunn, C. L., KELLY, R. W., & Critchley, H. (2003) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)61745-2 · Cited by 245
Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5′ CpG island in endometriosis
Xue, Q., Lin, Z., Yin, P., Milad, M. P., Cheng, Y.-H., Confino, E., Reierstad, S., & Bulun, S. E. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0494 · Cited by 219
Stimulation of Aromatase P450 Promoter (II) Activity in Endometriosis and Its Inhibition in Endometrium Are Regulated by Competitive Binding of Steroidogenic Factor-1 and Chicken Ovalbumin Upstream Promoter Transcription Factor to the Same cis-Acting Element
Zeitoun, K., Takayama, K., Michael, M. D., & Bulun, S. E. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.2.0229 · Cited by 216
17 beta-Hydroxysteroid dehydrogenase type 2: chromosomal assignment and progestin regulation of gene expression in human endometrium.
Casey, M. L., MacDonald, P. C., & Andersson, S. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117569 · Cited by 212
Aromatase inhibitors: the next generation of therapeutics for endometriosis?
Attar, E., & Bulun, S. E. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.09.064 · Cited by 184
Steroidogenic Enzyme Gene Expression in the Human Heart
Kayes, K. M., & White, P. C. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6663 · Cited by 174
In Situ Estrogen Synthesized by Aromatase P450 in Uterine Leiomyoma Cells Promotes Cell Growth Probably Via an Autocrine/Intracrine Mechanism
Sumitani, H., Shozu, M., Segawa, T., Murakami, K., Yang, H.-J., Shimada, K., & Inoue, M. (2000) · Endocrinology · doi:10.1210/endo.141.10.7719 · Cited by 155
Regulation of steroidogenic acute regulatory protein expression and progesterone production in endometriotic stromal cells.
Tsai, S.-J., Wu, M.-H., Lin, C.-C., Sun, H. S., & Chen, H.-M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8082 · Cited by 155
Aromatase in endometriosis and uterine leiomyomata
Bulun, S. E., Imir, G., Utsunomiya, H., Thung, S., Gurates, B., Tamura, M., & Lin, Z. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2005.04.012 · Cited by 154
Expression of the CYP19 gene and its product aromatase cytochrome P450 in human uterine leiomyoma tissues and cells in culture
Bulun, S. E., Simpson, E. R., & Word, R. A. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.3.8126151 · Cited by 152
Gene induction and categorical reprogramming during in vitro human endometrial fibroblast decidualization
Brar, A. K., Handwerger, S., Kessler, C. A., & Aronow, B. J. (2001) · Physiological Genomics · doi:10.1152/physiolgenomics.00061.2001 · Cited by 149
Regulation of Insulin-Like Growth Factor-Binding Protein-1 Synthesis and Secretion by Progestin and Relaxin in Long Term Cultures of Human Endometrial Stromal Cells*
Bell, S. C., Jackson, J., ASHMORE, J., Zhu, H., & Tseng, L. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-5-1014 · Cited by 141
Estrogen metabolizing enzymes in endometrium and endometriosis
Dassen, H., Punyadeera, C., Kamps, R., Delvoux, B., Van Langendonckt, A., Donnez, J., Husen, B., Thole, H., Dunselman, G., & Groothuis, P. (2007) · Human Reproduction · doi:10.1093/humrep/dem310 · Cited by 141
Dickkopf-1, an Inhibitor of Wnt Signaling, Is Regulated by Progesterone in Human Endometrial Stromal Cells
Tulac, S., Overgaard, M. T., Hamilton, A. E., Jumbe, N. L. ‘., Suchanek, E., & Giudice, L. C. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0769 · Cited by 133
Self-citation
Estrogen production in endometriosis and use of aromatase inhibitors to treat endometriosis.
Bulun, S. E., Zeitoun, K. M., Takayama, K., Noble, L., Michael, D., Simpson, E. R., Johns, A., Putman, M., & Sasano, H. (1999) · Endocrine Related Cancer · doi:10.1677/erc.0.0060293 · Cited by 124
Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone
Jones, M. C., Fusi, L., HIGHAM, J. M., Abdel-Hafiz, H. A., Horwitz, K. B., Lam, E. W. ‐., & Brosens, J. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603002103 · Cited by 115
Aromatase expression in endometriotic tissues and cell cultures of patients with endometriosis
Velasco, I. (2006) · Molecular Human Reproduction · doi:10.1093/molehr/gal041 · Cited by 108
ESTROGEN SYNTHESIS IN NORMAL AND MALIGNANT HUMAN ENDOMETRIUM
Tseng, L., Mazella, J., Mann, W. J., & Chumas, J. C. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-55-5-1029 · Cited by 103
Steroidal regulation of endometriosis tissue: lack of induction of 17β-hydroxysteroid dehydrogenase activity by progesterone, medroxyprogesterone acetate, or danazol
Vierikko, P., Kauppila, A., Rönnberg, L., & Vihko, R. (1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48376-7 · Cited by 99
Activation of the protein kinase A pathway in human endometrial stromal cells reveals sequential categorical gene regulation
Tierney, E. P., Tulac, S., Huang, S.-T. J., & Giudice, L. C. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00066.2003 · Cited by 98
Self-citation
Aromatase in Aging Women
Bulun, S. E., Zeitoun, K. M., Sasano, H., & Simpson, E. R. (1999) · Seminars in Reproductive Medicine · doi:10.1055/s-2007-1016244 · Cited by 92
Genetic or enzymatic disruption of aromatase inhibits the growth of ectopic uterine tissue
Fang, Z., Yang, S., Gurates, B., Tamura, M., Simpson, E., Evans, D., & Bulun, S. E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.7.8683 · Cited by 91
Interleukin-1 Induces the Expression of Insulin-Like Growth Factor Binding Protein-1 during Decidualization in the Primate
Straková, Z., Srisuparp, S., & Fazleabas, A. T. (2000) · Endocrinology · doi:10.1210/endo.141.12.7810 · Cited by 87
In Vivo Infusion of Interleukin-1β and Chorionic Gonadotropin Induces Endometrial Changes that Mimic Early Pregnancy Events in the Baboon
Straková, Z., Mavrogianis, P. A., Meng, X., Hastings, J. M., Jackson, K. S., Cameo, P., Brudney, A., Knight, O., & Fazleabas, A. T. (2005) · Endocrinology · doi:10.1210/en.2005-0380 · Cited by 79
Estrogenicity of Isoflavones on Human Endometrial Stromal and Glandular Cells
Kayisli, U. A., Aksu, C. A. H., Berkkanoğlu, M., & Arici, A. M. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020716 · Cited by 79
Regulation of Aromatase P450 Expression in Endometriotic and Endometrial Stromal Cells by CCAAT/Enhancer Binding Proteins (C/EBPs): Decreased C/EBPβ in Endometriosis Is Associated with Overexpression of Aromatase
Yang, S., Fang, Z., Suzuki, T., Sasano, H., Zhou, J., Gurates, B., Tamura, M., Ferrer, K., & Bulun, S. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8486 · Cited by 77
Polymerase chain reaction amplification fails to detect aromatase cytochrome P450 transcripts in normal human endometrium or decidua.
Bulun, S. E., Mahendroo, M., & Simpson, E. R. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.6.7684741 · Cited by 77
Upstream stimulatory factor-2 regulates steroidogenic factor-1 expression in endometriosis
Utsunomiya, H., Cheng, Y.-H., Lin, Z., Reierstad, S., Yin, P., Attar, E., Xue, Q., Imir, G., Thung, S., Trukhacheva, E., et al. (2008) · Molecular Endocrinology · doi:10.1210/me.2006-0302 · Cited by 72
Differential Effects of Progestin and Relaxin on the Synthesis and Secretion of Immunoreactive Prolactin in Long Term Culture of Human Endometrial Stromal Cells*
Zhu, H., HUANG, J. R., Mazella, J., Rosenberg, M. I., & Tseng, L. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-4-889 · Cited by 71
Expression of Aromatase and Estrogen Sulfotransferase in Eutopic and Ectopic Endometrium: Evidence for Unbalanced Estradiol Production in Endometriosis
Hudelist, G., Czerwenka, K., Keckstein, J., Haas, C., Fink-Retter, A., Gschwantler-Kaulich, D., Kubista, E., & Singer, C. F. (2007) · Reproductive Sciences · doi:10.1177/1933719107309120 · Cited by 70
Tissue‐Specific Estrogen Biosynthesis and Metabolism
SIMPSON, E. R., Clyne, C. D., Speed, C. J., RUBIN, G., & Bulun, S. E. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb04002.x · Cited by 65
Disparate effects of relaxin and TGF 1: relaxin increases, but TGF 1 inhibits, the relaxin receptor and the production of IGFBP-1 in human endometrial stromal/decidual cells
Mazella, J. (2004) · Human Reproduction · doi:10.1093/humrep/deh274 · Cited by 62
Analysis of aromatase and 17β-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression in deep endometriosis and eutopic endometrium using laser capture microdissection
Matsuzaki, S., Canis, M. J., Pouly, J. L., Déchelotte, P. J., & Mage, G. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.08.017 · Cited by 61
Wild-Type p53 Protein Is Up-Regulated upon Cyclic Adenosine Monophosphate-Induced Differentiation of Human Endometrial Stromal Cells
Pohnke, Y., Schneider‐Merck, T., Fahnenstich, J., Kempf, R., Christian, M., Milde‐Langosch, K., Brosens, J. J., & Gellersen, B. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0012 · Cited by 58
Two 17β-hydroxysteroid dehydrogenases (17HSDs) of estradiol biosynthesis: 17HSD type 1 and type 7
Peltoketo, H., Nokelainen, P., Piao, Y.-S., Vihko, R., & Vihko, P. (1999) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(99)00064-3 · Cited by 54
The Relationship Between the In Vitro Activity of 3β-Hydroxysteroid Dehydrogenase Δ4–5-Isomerase in Human Sebaceous Glands and Their Secretory Activity In Vivo
Simpson, N., Cunliffe, W. J., & Hodgins, M. B. (1983) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12543363 · Cited by 46
SP1 and SP3 Mediate Progesterone-Dependent Induction of the 17beta Hydroxysteroid Dehydrogenase Type 2 Gene in Human Endometrium1
Cheng, Y.-H., Imir, A. G., Suzuki, T., Fenkçi, V., Yılmaz, B., Sasano, H., & Bulun, S. E. (2006) · Biology of Reproduction · doi:10.1095/biolreprod.106.051912 · Cited by 44
CYP17 genetic polymorphism in endometrial cancer: are only steroids involved?
Berstein, L. M., Имянитов, Е. Н., Gamajunova, V. B., Ковалевский, А. Ю., Kuligina, E. S., Белогубова, Е. В., Buslov, K. G., Karpova, M. B., Togo, A. V., Volkov, O. N., et al. (2002) · Cancer Letters · doi:10.1016/s0304-3835(02)00019-8 · Cited by 44
Androstenedione up-regulation of endometrial aromatase expression via local conversion to estrogen: potential relevance to the pathogenesis of endometriosis.
Bukulmez, O., Hardy, D., Carr, B. R., Auchus, R., Toloubeydokhti, T., Word, R., & Mendelson, C. R. (2008) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2008-0248 · Cited by 40
Role of activin A as a mediator of in vitro endometrial stromal cell decidualization via the cyclic adenosine monophosphate pathway
Tierney, E. P., & Giudice, L. C. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.09.031 · Cited by 39
Self-citation
Physical Interaction and Mutual Transrepression between CCAAT/Enhancer-binding Protein β and the p53 Tumor Suppressor
Schneider‐Merck, T., Pohnke, Y., Kempf, R., Christian, M., Brosens, J. J., & Gellersen, B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503459200 · Cited by 34
A predictive model for endometriosis
Wölfler, M. M., Nagele, F., Kolbus, A., Seidl, S., Schneider, B., Huber, J. C., & Tschugguel, W. (2005) · Human Reproduction · doi:10.1093/humrep/deh796 · Cited by 33
Paracrine regulation of endometriotic tissue
Minici, F., Tiberi, F., Tropea, A., Miceli, F., Orlando, M., Gangale, M. F., Romani, F., Catino, S., Campo, S., Lanzone, A., et al. (2007) · Gynecological Endocrinology · doi:10.1080/09513590701581721 · Cited by 33
Implantation defect in endometriosis: endometrium or peritoneal fluid.
Selam, B., & Arici, A. M. (2000) · PubMed · Cited by 31
Expression of Aromatase Cytochrome P450 in Eutopic Endometrium and Its Application as a Diagnostic Test for Endometriosis
Kitawaki, J., Kusuki, I., Koshiba, H., Tsukamoto, K., & Honjo, H. (1999) · Gynecologic and Obstetric Investigation · doi:10.1159/000052865 · Cited by 30
Human type 2 17beta-hydroxysteroid dehydrogenase mRNA and protein distribution in placental villi at mid and term pregnancy
Drolet, R., Simard, M., Plante, J., Laberge, P. Y., & Tremblay, Y. (2007) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-5-30 · Cited by 30
DDE-Induced Changes in Aromatase Activity in Endometrial Stromal Cells in Culture
Holloway, A. C., Stys, K. A., & Foster, W. G. (2005) · Endocrine · doi:10.1385/endo:27:1:045 · Cited by 28
Expression of 3b-Hydroxysteroid dehydrogenase and P450 side chain cleavage enzyme in the human uterine endometrium
Rhee, H. S., Oh, S. H., Ko, B. J., Han, D. M., Jeon, B. H., Park, H., Moon, H. B., & Kim, W. S. (2003) · Experimental & Molecular Medicine · doi:10.1038/emm.2003.22 · Cited by 28
Localization of type 1 17beta-hydroxysteroid dehydrogenase mRNA and protein in syncytiotrophoblasts and invasive cytotrophoblasts in the human term villi
Bonenfant, M., Pr, P., Drolet, R., & Tremblay, Y. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1650217 · Cited by 26
The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis
Maia, H., Casoy, J., Correia, T., Freitas, L., Pimentel, K., & Athayde, C. (2008) · Gynecological Endocrinology · doi:10.1080/09513590801890816 · Cited by 25
Mid-luteal endometrial intracrinology following controlled ovarian hyperstimulation involving use of a gonadotrophin releasing hormone antagonist
Vani, S., McDonald, S. E., Williams, A. R. W., Mason, J. I., Thong, K. J., & Critchley, H. (2007) · Human Reproduction · doi:10.1093/humrep/dem269 · Cited by 16
Androstenedione Up-Regulation of endometrial aromatase expression via local conversion to estrogen potential relevance to the pathogenesis of endometriosis
Bukulmez, O., Hardy, D., Carr, B., Auchus, R., Toloubeydokhti, T., Word, R., & Mendelson, C. (2009) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000345377.28368.a5 · Cited by 2

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Authors: Aghajanova, L., Hamilton, A., Kwintkiewicz, J., Vo, K. C., & Giudice, L. C.
Affiliations: University of California, San Francisco (US)
Corresponding author: Giudice, L.C.
ORCID: Aghajanova, L.
Vo, K.C.
Giudice, L.C.
Venue: Biology of Reproduction
Publisher: Oxford University Press (OUP)
Published: 2009-01-01
Volume: 80
Issue: 1
Pages: 105-114
ISSN: 0006-3363 (ISSN-L)
1529-7268
DOI: 10.1095/biolreprod.108.070300
PMC: PMC2704986
OpenAlex: W2103654313
Cited by: 168
References: 78
Citations by year: 2026: 5 · 2025: 7 · 2024: 3 · 2023: 5 · 2022: 9 · 2021: 6 · 2020: 11 · 2019: 8 · 2018: 13 · 2017: 11 · 2016: 10 · 2015: 7 · 2014: 8 · 2013: 12 · 2012: 11
FWCI: 16.27
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Biology of Reproduction (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
BioOne Complete (BioOne) (submittedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD055764)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: endometriosis, endometrial stromal fibroblasts, decidualization, steroidogenic enzymes, aromatase, estradiol, progesterone, 8-bromo-cAMP, protein kinase A, HSD3B1, HSD17B1, HSD17B2, IGFBP-1, prolactin, implantation failure, eutopic endometrium
MeSH terms: Adult, Aromatase, Decidua, Endometriosis, Endometrium, Enzyme-Linked Immunosorbent Assay, Estradiol, Estradiol Dehydrogenases, Female, Humans, Immunohistochemistry, Middle Aged, Progesterone, Prolactin, RNA, Messenger, 8-Bromo Cyclic Adenosine Monophosphate, Stromal Cells, Insulin-Like Growth Factor Binding Protein 1, Reverse Transcriptase Polymerase Chain Reaction, Young Adult

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Steroidogenic Enzyme and Key Decidualization Marker Dysregulation in Endometrial Stromal Cells from Women with Versus Without Endometriosis1

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