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Cited by 357Endometriosis Research and TreatmentHealth Systems, Economic Evaluations, Quality of LifeEctopic Pregnancy Diagnosis and Management

Endometriosis: cost estimates and methodological perspective

Simoens, S., Hummelshoj, L., D'Hooghe, T.·2007·Human Reproduction Update
DOI 10.1093/humupd/dmm010
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Abstract

This article aims to provide a systematic review of estimates and methodology of studies quantifying the costs of endometriosis. Included studies were cost-of-illness analyses quantifying the economic impact of endometriosis and cost analyses calculating diagnostic and treatment costs of endometriosis. Annual healthcare costs and costs of productivity loss associated with endometriosis have been estimated at $2801 and $1023 per patient, respectively. Extrapolating these findings to the US population, this study calculated that annual costs of endometriosis attained $22 billion in 2002 assuming a 10% prevalence rate among women of reproductive age. These costs are considerably higher than those related to Crohn's disease or to migraine. To date, it is not possible to determine whether a medical approach is less expensive than a surgical approach to treating endometriosis in patients presenting with chronic pelvic pain. Evidence of endometriosis costs in infertile patients is largely lacking. Cost estimates were biased due to the absence of a control group of patients without endometriosis, inadequate consideration of endometriosis recurrence and restricted scope of costs. There is a need for more and better-designed studies that carry out longitudinal analyses of patients until the cessation of their symptoms or that model the chronic nature of endometriosis.

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Crossref · 10.1093/humupd/dmm010

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  • The yearly total cost of endometriosis has been estimated at €30 billion in Europe and $22 billion in the US, with direct costs increasing steadily.

    “The yearly total (direct plus indirect) cost of endometriosis has been estimated at €30 billion in Europe and $22 billion in the US, and direct costs have increased steadily (13,18-20).”

    From Patients’ report on how endometriosis affects health, work, and daily life (2010) · cites this paper as [19]

  • According to studies based on 2002 US data, the global annual cost of endometriosis, including analgesics, hormonal therapies, gynaecological consultations, hospital admissions, surgical procedures, days off-work and reduced productivity, varies between $18.8 and $22 billion.

    “According to studies based on 2002 US data, the global cost of the disease (including analgesics, hormonal therapies, gynaecological consultations, hospital admissions, surgical procedures, days off-work and reduced productivity) varies between $18.8 and $22 billion per year (Gao et al., 2006;Simoens et al., 2007)”

    From “Waiting for Godot”: a commonsense approach to the medical treatment of endometriosis (2011) · cites this paper as Simoens et al., 2007

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Authors
Simoens, S., Hummelshoj, L., & D'Hooghe, T.
Affiliations
KU Leuven (BE)
ORCID
Simoens, S.
Venue
Human Reproduction Update
Publisher
Oxford University Press (OUP)
Published
2007-07-01
Volume
13
Issue
4
Pages
395-404
ISSN
  • 1355-4786 (ISSN-L)
  • 1460-2369
DOI
10.1093/humupd/dmm010
OpenAlex
W2114245999
Cited by
357
References
45
Citations by year
2026: 8 · 2025: 3 · 2024: 10 · 2023: 15 · 2022: 14 · 2021: 14 · 2020: 23 · 2019: 23 · 2018: 27 · 2017: 17 · 2016: 15 · 2015: 19 · 2014: 22 · 2013: 26 · 2012: 20
FWCI
3.51
Type
journal article
Language
en
Open access
closed
Locations
  • Human Reproduction Update (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Keywords
endometriosis, economic burden, health care costs, productivity loss, diagnostic costs, treatment costs, chronic pelvic pain, infertility, endometriosis recurrence, cost estimation methodology
MeSH terms
Endometriosis, Female, Humans, United States, Prevalence, Cost of Illness

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