Cited by 154Endometriosis Research and TreatmentEstrogen and related hormone effectsUterine Myomas and Treatments

Aromatase in endometriosis and uterine leiomyomata

Bulun, Serdar E., Imir, Gonca, Utsunomiya, Hiroki, Thung, Steven, Gurates, Bilgin, Tamura, Mitsutoshi, Lin, Zhihong·2005·The Journal of Steroid Biochemistry and Molecular Biology

Abstract

Endometrial tissue from uterine disease-free women does not exhibit aromatase activity. In contrast, aromatase enzyme activity and mRNA levels are readily detectable in endometriosis. PGE2 stimulates both aromatase expression and activity in endometriotic stromal cells via promoter II region of the aromatase gene. This results in local production of estradiol, which induces PGE2 formation and establishes a positive feedback cycle. This mechanism seems to contribute to continuous production of estradiol and PGE2. Aromatase mRNA levels and enzyme activity are also present in uterine leiomyomata that are estrogen-dependent benign tumors of the myometrium. Successful treatment of endometriosis and uterine leiomyomata using aromatase inhibitors by recent pilot trials underscores the clinical significance of these molecular studies.

Integrity signals

Registry

Crossref · 10.1016/j.jsbmb.2005.04.012

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35 of 35 references verified0 citation errors · 0 not checkable

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Authors
Bulun, S. E., Imir, G., Utsunomiya, H., Thung, S., Gurates, B., Tamura, M., & Lin, Z.
Affiliations
Northwestern University (US)
Corresponding author
Bulun, Serdar E.
Venue
The Journal of Steroid Biochemistry and Molecular Biology
Publisher
Elsevier BV
Published
2005-05
Volume
95
Issue
1-5
Pages
57-62
ISSN
0960-0760 (ISSN-L)
OpenAlex
W2119512564
Cited by
154
References
37
Citations by year
2026: 2 · 2025: 2 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 11 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 6 · 2014: 11 · 2013: 3 · 2012: 11
FWCI
10.90
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD046260, HD-38691, HD46260)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
Keywords
aromatase, endometriosis, uterine fibroids, prostaglandin E2, endometrial stromal cells, estradiol production, positive feedback loop, aromatase inhibitors, estrogen-dependent tumors
MeSH terms
Aromatase, Endometriosis, Estrogens, Female, Humans, Leiomyoma, Uterine Neoplasms, Uterus, Aromatase Inhibitors

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