Cited by 169Endometriosis Research and TreatmentReproductive System and PregnancyEstrogen and related hormone effects

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Steroidogenic Enzyme and Key Decidualization Marker Dysregulation in Endometrial Stromal Cells from Women with Versus Without Endometriosis1

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Aghajanova, L., Hamilton, A., Kwintkiewicz, J., Vo, K.C., Giudice, L.C.·2009·Biology of Reproduction

DOI 10.1095/biolreprod.108.070300PMC PMC2704986

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Abstract

Identification of mechanisms underlying endometriosis pathogenesis will facilitate understanding and treatment of infertility and pain associated with this disorder. Herein, we investigated the expression of steroidogenic pathway enzymes and key decidualization biomarkers in endometrial tissue and in eutopic endometrial stromal fibroblasts (hESFs) from women with vs. those without endometriosis, and subsequently treated in vitro with 8-bromo-cAMP (8-Br-cAMP) or progesterone (P4). Real-time quantitative PCR, immunohistochemistry, ELISA, and radiometric aromatase activity assay were used. The results demonstrate significantly increased (14.5-fold; P=0.037) expression of aromatase in eutopic endometrium of women with disease. In 8-Br-cAMP-treated hESF from eutopic endometrium of women with endometriosis, the balance in estradiol (E2) and P4 biosynthetic and metabolizing enzymes is disturbed (decreased HSD3B1 and HSD17B2, and increased HSD17B1 and aromatase), with the equilibrium being shifted towards an E2-enriched milieu. However, hESF from the same group of women treated with P4 did not demonstrate such responsiveness. Lower expression of IGFBP1 and prolactin mRNA and protein was observed in hESF from women with vs. those without endometriosis in response to 8-Br-cAMP, but not P4, suggesting a blunted response of these decidual biomarkers to activation of the PKA pathway in eutopic endometrium in women with disease. The dichotomy of 8-Br-cAMP regulation of select steroidogenic enzymes leading to an enriched E2 milieu within the endometrium and a blunted response of decidual biomarkers to this decidualizing agent of hESF from women with endometriosis suggests resistance to full decidualization of the stromal fibroblasts and mechanisms underlying implantation failure and the pathophysiology of this disorder.

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Authors: Aghajanova, L., Hamilton, A., Kwintkiewicz, J., Vo, K. C., & Giudice, L. C.
Affiliations: University of California, San Francisco (US)
Corresponding author: Giudice, L.C.
ORCID: Aghajanova, L.
Vo, K.C.
Giudice, L.C.
Venue: Biology of Reproduction
Publisher: Oxford University Press (OUP)
Published: 2009-01-01
Volume: 80
Issue: 1
Pages: 105-114
ISSN: 0006-3363 (ISSN-L)
1529-7268
DOI: 10.1095/biolreprod.108.070300
PMC: PMC2704986
OpenAlex: W2103654313
Cited by: 168
References: 78
Citations by year: 2026: 5 · 2025: 7 · 2024: 3 · 2023: 5 · 2022: 9 · 2021: 6 · 2020: 11 · 2019: 8 · 2018: 13 · 2017: 11 · 2016: 10 · 2015: 7 · 2014: 8 · 2013: 12 · 2012: 11
FWCI: 16.27
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Biology of Reproduction (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
BioOne Complete (BioOne) (submittedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD055764)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: endometriosis, endometrial stromal fibroblasts, decidualization, steroidogenic enzymes, aromatase, estradiol, progesterone, 8-bromo-cAMP, protein kinase A, HSD3B1, HSD17B1, HSD17B2, IGFBP-1, prolactin, implantation failure, eutopic endometrium
MeSH terms: Adult, Aromatase, Decidua, Endometriosis, Endometrium, Enzyme-Linked Immunosorbent Assay, Estradiol, Estradiol Dehydrogenases, Female, Humans, Immunohistochemistry, Middle Aged, Progesterone, Prolactin, RNA, Messenger, 8-Bromo Cyclic Adenosine Monophosphate, Stromal Cells, Insulin-Like Growth Factor Binding Protein 1, Reverse Transcriptase Polymerase Chain Reaction, Young Adult

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Steroidogenic Enzyme and Key Decidualization Marker Dysregulation in Endometrial Stromal Cells from Women with Versus Without Endometriosis1

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