Endometriosis Is Associated with Progesterone Resistance in the Baboon (Papio anubis) Oviduct: Evidence Based on the Localization of Oviductal Glycoprotein 1 (OVGP1)1
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Endometriosis has been associated with a reduced response to progesterone in both the eutopic and ectopic endometrium. In this study we evaluated OVGP1 and steroid receptor expression in oviducts of baboons with endometriosis during the midsecretory phase and determined whether progesterone resistance associated with endometriosis also occurs in the oviduct. Oviducts obtained during the window of uterine receptivity (Day 10 postovulation [PO]) from animals with induced and spontaneous disease were compared to control animals during the proliferative stage and in the implantation window as well as animals treated with the progesterone receptor (PGR) antagonist ZK 137.299 (ZK). OVGP1 was significantly higher in animals with endometriosis compared with Day 10 PO controls and was similar to that seen in the late proliferative phase and in ZK-treated animals. Baboons with spontaneous endometriosis also showed a similar persistence of OVGP1, which was correlated with the maintenance of estrogen receptor 1 (ESR1) in the epithelial cells of animals with endometriosis. However, epithelial cell height and the percentage of ciliation were not affected by endometriosis. These data imply that the normal antagonism of progesterone on ESR and OVGP1, which results in their downregulation during the window of implantation, is absent in animals with endometriosis. This was confirmed further when the action of PGR was antagonized in animals without disease, which also resulted in the persistence of ESR1 and OVGP1. These studies suggest that an aberrant oviductal environment may be an additive factor that contributes to endometriosis-associated infertility.
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Local estrogen production and progesterone resistance were demonstrated in larger endometriosis lesions.
“Local estrogen production (154) and progesterone resistance (155-162) were demonstrated in larger endometriosis lesions (154-163)”
From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [156]
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- Authors
- Wang, C., Mavrogianis, P. A., & Fazleabas, A. T.
- Affiliations
- Peking University (CN)
- University of Illinois Chicago (US)
- Corresponding author
- Fazleabas, Asgerally T.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-02-01
- Volume
- 80
- Issue
- 2
- Pages
- 272-278
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- PMC
- PMC2662730
- OpenAlex
- W2154970521
- Cited by
- 30
- References
- 35
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2022: 2 · 2019: 1 · 2018: 4 · 2017: 5 · 2013: 4 · 2012: 2
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biology of Reproduction (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- BioOne Complete (BioOne) (submittedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD040093, U54-HD40093)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- endometriosis, progesterone resistance, oviduct, OVGP1, progesterone receptor, estrogen receptor 1, baboons, Papio anubis, implantation window, endometrial receptivity, endometriosis-associated infertility, ectopic endometrium
- MeSH terms
- Animals, Drug Resistance, Endometriosis, Endometrium, Fallopian Tubes, Female, Glycoproteins, Peritoneal Diseases, Progesterone, Receptors, Progesterone, Tissue Distribution, Estrogen Receptor alpha, Papio anubis
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