CoChat
Sign Up
Cited by 122Endometriosis Research and TreatmentReproductive System and PregnancyEctopic Pregnancy Diagnosis and Management

Reduced progesterone action during endometrial maturation: A potential risk factor for the development of endometriosis

Open access
Osteen, Kevin G., Bruner-Tran, Kaylon L., Eisenberg, Esther·2005·Fertility and Sterility
DOI 10.1016/j.fertnstert.2004.11.026
Open this paper in CoChat — free accountOpen PDF

Abstract

Objective To discuss the role that reduced endometrial responsiveness to progesterone (P) might play in the pathophysiology of endometriosis. Design A review of experimental evidence regarding the failure of P to regulate the expression of matrix metalloproteinases (MMPs) in the endometrium of patients with endometriosis. Conclusion(s) Progesterone and locally produced differentiation factors act cooperatively to reduce MMP expression by maternal endometrial cells within the pro-inflammatory micro-environment of early pregnancy. Our in vitro studies with normal human endometrium demonstrate that prior P exposure not only down-regulates MMP expression, but also limits the ability of locally produced proinflammatory cytokines to stimulate expression of these enzymes. In contrast, endometrial tissues from women with endometriosis demonstrate an altered response to P, allowing a continuous expression of MMPs throughout the secretory phase. Although the factors that influence the loss of P sensitivity in the endometrium of patients with endometriosis have not yet been defined, alterations in cell-cell communication seem to contribute to dysregulated MMP expression. Specifically, proinflammatory cytokines produced by epithelial cells oppose stromal cell responses to P, inhibiting production of key differentiation factors necessary for cell-specific MMP regulation. The resulting loss in normal MMP regulation enhances the invasive capacity of endometrial tissue, promoting ectopic establishment in an experimental model.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.fertnstert.2004.11.026

Cites

63 of 63 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Reduced progesterone action in endometrium, called progesterone resistance, in women with endometriosis may play a key role in development of endometriosis and possibly associated pain; progestagens may reverse these effects.

    “A reduction in progesterone action in endometrium, 'progesterone resistance', of women with endometriosis (Osteen et al., 2005; Table V) may play a key role in development of endometriosis and possibly with associated pain; use of progestagens may reverse these effects.”

    From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Osteen et al., 2005

    The Abstract and Figure 2 describe reduced endometrial progesterone responsiveness in women with endometriosis and propose that it contributes to disease development. Clinical Considerations identifies progestins as treatments for endometriosis-associated pelvic pain, and the Abstract says progestin-based therapies can lead to disease regression in some women. The paper does not establish that progesterone resistance causes the pain or that progestagens reverse the resistance itself; it also notes that proposed progesterone supplementation for symptoms had not been tested in randomized trials. Our copy provides section labels but no page numbers for these passages. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Eutopic endometrium in women with endometriosis shows reduced progesterone action during maturation, called progesterone resistance, which may enhance endometriosis development.

    “Osteen et al. (2005) demonstrated that eutopic endometrium of women with endometriosis has reduced progesterone action during maturation or 'progesterone resistance', that, in turn, may enhance development of endometriosis.”

    From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Osteen et al., 2005

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Bruner-Tran KL, Webster-Clair D, Osteen KG. Experimental endome- triosis: the nude mouse as a xenographic host. Ann N Y Acad Sci 2002;955:328 -39.

Cited by

Sorted by citations

Related

Authors
Osteen, K. G., Bruner-Tran, K. L., & Eisenberg, E.
Affiliations
Vanderbilt University (US)
Corresponding author
Osteen, Kevin G.
ORCID
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2005-03
Volume
83
Issue
3
Pages
529-537
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/j.fertnstert.2004.11.026
OpenAlex
W1966049599
Cited by
122
References
63
Citations by year
2026: 2 · 2025: 1 · 2023: 2 · 2022: 7 · 2021: 8 · 2020: 2 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 11
FWCI
1.56
Type
journal article
Language
en
Open access
Licence
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Environmental Health Sciences (R21ES12298-01, R21ES012298)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (5K12HD43483, U54HD037321, U54 HD37321, K12HD043483)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Keywords
endometriosis, progesterone, endometrial maturation, matrix metalloproteinases, endometrial receptivity, inflammatory cytokines, endometrial invasion, luteal phase, intercellular communication, ectopic endometrium
MeSH terms
Endometriosis, Endometrium, Female, Humans, Pregnancy, Progesterone, Risk Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review