The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Perivascular Human Endometrial Mesenchymal Stem Cells Express Pathways Relevant to Self-Renewal, Lineage Specification, and Functional Phenotype1
Open accessAbstract
Human endometrium regenerates on a cyclic basis from candidate stem/progenitors whose genetic programs are yet to be determined. A subpopulation of endometrial stromal cells, displaying key properties of mesenchymal stem cells (MSCs), has been characterized. The endometrial MSC (eMSC) is likely the precursor of the endometrial stromal fibroblast. The goal of this study was to determine the transcriptome and signaling pathways in the eMSC to understand its functional phenotype. Endometrial stromal cells from oocyte donors (n = 20) and patients undergoing benign gynecologic surgery (n = 7) were fluorescence-activated cell sorted into MCAM (CD146)(+)/PDGFRB(+) (eMSC), MCAM (CD146)(-)/PDGFRB(+) (fibroblast), and MCAM (CD146)(+)/PDGFRB(-) (endothelial) populations. The eMSC population contained clonogenic cells with a mesenchymal phenotype differentiating into adipocytes when cultured in adipogenic medium. Gene expression profiling using Affymetrix Human Gene 1.0 ST arrays revealed 762 and 1518 significantly differentially expressed genes in eMSCs vs. stromal fibroblasts and eMSCs vs. endothelial cells, respectively. By principal component and hierarchical clustering analyses, eMSCs clustered with fibroblasts and distinctly from endothelial cells. Endometrial MSCs expressed pericyte markers and were localized by immunofluorescence to the perivascular space of endometrial small vessels. Endometrial MSCs also expressed genes involved in angiogenesis/vasculogenesis, steroid hormone/hypoxia responses, inflammation, immunomodulation, cell communication, and proteolysis/inhibition, and exhibited increased Notch, TGFB, IGF, Hedgehog, and G-protein-coupled receptor signaling pathways, characteristic of adult tissue MSC self-renewal and multipotency. Overall, the data support the eMSC as a clonogenic, multipotent pericyte that displays pathways of self-renewal and lineage specification, the potential to respond to conditions during endometrial desquamation and regeneration, and a genetic program predictive of its differentiated lineage, the stromal fibroblast.
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Cites
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A perivascular origin for mesenchymal stem cells in multiple human organs
Crisan, M., Yap, S., Casteilla, L., Chen, C.-W., Corselli, M., Park, T. S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.003 · Cited by 3,991 · cited 6×
“Interestingly, MSC pericytes migrate in an in vitro culture model toward proteolytic digests of extracellular matrix, consistent with the important property of progenitors to migrate to the site of injured tissue for reconstruction [16].”
BackgroundMethodResultInfluentialIdentifying differentially expressed genes using false discovery rate controlling procedures
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Clonogenicity of Human Endometrial Epithelial and Stromal Cells1
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Self-citationSchwab, K. E., & Gargett, C. E. (2007) · Human Reproduction · doi:10.1093/humrep/dem265 · Cited by 545
Contribution of Bone Marrow-Derived Stem Cells to Endometrium and Endometriosis
Du, H., & Taylor, H. S. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0828 · Cited by 449 · cited 4×
“Stem/progenitor cells (epithelial, mesenchymal, endothelial) likely contribute to the rapid endometrial cyclic growth and regeneration of 4–14 mm of mucosa per cycle during the more than 400 cycles in a woman’s reproductive lifespan and endometrial regeneration/ repair postpartum [6–8].”
BackgroundInfluentialAdult stem cells in the endometrium
Gargett, C. E., & Masuda, H. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gaq061 · Cited by 361
The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy
Hoogduijn, M. J., Popp, F., Verbeek, R., Masoodi, M., Nicolaou, A., Baan, C., & Dahlke, M.-H. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.06.019 · Cited by 248
Regulation of human endometrial function: mechanisms relevant to uterine bleeding
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Cited by
Endometrial stem/progenitor cells: the first 10 years
Gargett, C. E., Schwab, K. E., & Deane, J. A. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv051 · Cited by 561
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Adenomyosis: Mechanisms and Pathogenesis
Zhai, J., Vannuccini, S., Petraglia, F., & Giudice, L. C. (2020) · Seminars in Reproductive Medicine · doi:10.1055/s-0040-1716687 · Cited by 292
Self-citationType-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner
Birbrair, A., Zhang, T., Files, D. C., Mannava, S., Smith, T., Wang, Z.-M., Messi, M. L., Mintz, A., & Delbono, O. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt512 · Cited by 282
Laganà, A. S., Vitale, S. G., Salmeri, F. M., Triolo, O., Ban Frangež, H., Vrtačnik-Bokal, E., Stojanovska, L., Apostolopoulos, V., Granese, R., & Sofo, V. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.03.032 · Cited by 221
Metadata
- Authors
- Spitzer, T. L. B., Rojas, A., Zelenko, Z., Aghajanova, L., Erikson, D. W., Barragan, F., Meyer, M., Tamaresis, J. S., Hamilton, A. E., Irwin, J. C., & Giudice, L. C.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-02-01
- Volume
- 86
- Issue
- 2
- Pages
- 58-58
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2146815044
- Cited by
- 216
- References
- 10
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Spitzer, T. L. B., Rojas, A., Zelenko, Z., Aghajanova, L., Erikson, D. W., Barragan, F., Meyer, M., Tamaresis, J. S., Hamilton, A. E., Irwin, J. C., & Giudice, L. C. (2012). Perivascular Human Endometrial Mesenchymal Stem Cells Express Pathways Relevant to Self-Renewal, Lineage Specification, and Functional Phenotype1. Biology of Reproduction. https://doi.org/10.1095/biolreprod.111.095885
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