Cited by 180Pregnancy and preeclampsia studiesBirth, Development, and HealthGestational Diabetes Research and Management

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Modulation of Fatty Acid Transport and Metabolism by Maternal Obesity in the Human Full-Term Placenta1

Dubé, Evemie, Gravel, Ariane, Martin, Coralie, Desparois, Guillaume, Moussa, Issa, Ethier-Chiasson, Maude, Forest, Jean-Claude, Giguère, Yves, Masse, André, Lafond, Julie·2012·Biology of Reproduction

DOI 10.1095/biolreprod.111.098095

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Abstract

Knowledge of the consequences of maternal obesity in human placental fatty acids (FA) transport and metabolism is limited. Animal studies suggest that placental uptake of maternal FA is altered by maternal overnutrition. We hypothesized that high maternal body mass index (BMI) affects human placental FA transport by modifying expression of key transporters. Full-term placentas were obtained by vaginal delivery from normal weight (BMI, 18.5-24.9 kg/m(2)) and obese (BMI > 30 kg/m(2)) women. Blood samples were collected from the mother at each trimester and from cord blood at delivery. mRNA and protein expression levels were evaluated with real-time RT-PCR and Western blotting. Lipoprotein lipase (LPL) activity was evaluated using enzyme fluorescence. In vitro linoleic acid transport was studied with isolated trophoblasts. Our results demonstrated that maternal obesity is associated with increased placental weight, decreased gestational age, decreased maternal high-density lipoprotein (HDL) levels during the first and third trimesters, increased maternal triglyceride levels during the second and third trimesters, and increased maternal T3 levels during all trimesters, and decreased maternal cholesterol (CHOL) and low-density lipoprotein (LDL) levels during the third trimester; and increased newborn CHOL, LDL, apolipoprotein B100, and T3 levels. Increases in placental CD36 mRNA and protein expression levels, decreased SLC27A4 and FABP1 mRNA and protein and FABP3 protein expression, and increased LPL activity and decreased villus cytotrophoblast linoleic acid transport were also observed. No changes were seen in expression of PPARA, PPARD, or PPARG mRNA and protein. Overall this study demonstrated that maternal obesity impacts placental FA uptake without affecting fetal growth. These changes, however, could modify the fetus metabolism and its predisposition to develop diseases later in life.

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Authors: Dubé, E., Gravel, A., Martin, C., Desparois, G., Moussa, I., Ethier-Chiasson, M., Forest, J.-C., Giguère, Y., Masse, A., & Lafond, J.
Affiliations: Université du Québec à Montréal (CA)
Hôpital Saint-François d'Assise (CA)
Centre Hospitalier de l’Université de Montréal (CA)
Corresponding author: Lafond, Julie
ORCID: Forest, Jean-Claude
Giguère, Yves
Lafond, Julie
Venue: Biology of Reproduction
Publisher: Oxford University Press (OUP)
Published: 2012-07-01
Volume: 87
Issue: 1
Pages: 14, 1-11
ISSN: 0006-3363 (ISSN-L)
1529-7268
DOI: 10.1095/biolreprod.111.098095
OpenAlex: W2113432131
Cited by: 180
References: 83
Citations by year: 2026: 4 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 9 · 2021: 14 · 2020: 15 · 2019: 18 · 2018: 17 · 2017: 23 · 2016: 20 · 2015: 15 · 2014: 11 · 2013: 10 · 2012: 3
FWCI: 15.05
Type: journal article
Language: en
Open access: closed
Locations: Biology of Reproduction (publishedVersion)
PubMed (publishedVersion)
BioOne Complete (BioOne) (submittedVersion)
Funders: Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Keywords: maternal obesity, placenta, fatty acid uptake, fatty acid metabolism, CD36, SLC27A4, FABP1, FABP3, lipoprotein lipase, trophoblast, HDL cholesterol, triglycerides, thyroid hormones, peroxisome proliferator-activated receptors, umbilical cord blood, fetal programming, body mass index
MeSH terms: Fatty Acid Binding Protein 3, Base Sequence, Biological Transport, Active, Fatty Acids, Female, Hormones, Humans, Infant, Newborn, Lipids, Lipoprotein Lipase, Maternal-Fetal Exchange, Models, Biological, Obesity, Placenta, Pregnancy, Pregnancy Complications, Case-Control Studies, DNA Primers, CD36 Antigens, Linoleic Acid, Peroxisome Proliferator-Activated Receptors, Fatty Acid-Binding Proteins, Fatty Acid Transport Proteins

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Modulation of Fatty Acid Transport and Metabolism by Maternal Obesity in the Human Full-Term Placenta1

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