The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Modulation of Fatty Acid Transport and Metabolism by Maternal Obesity in the Human Full-Term Placenta1
Abstract
Knowledge of the consequences of maternal obesity in human placental fatty acids (FA) transport and metabolism is limited. Animal studies suggest that placental uptake of maternal FA is altered by maternal overnutrition. We hypothesized that high maternal body mass index (BMI) affects human placental FA transport by modifying expression of key transporters. Full-term placentas were obtained by vaginal delivery from normal weight (BMI, 18.5-24.9 kg/m(2)) and obese (BMI > 30 kg/m(2)) women. Blood samples were collected from the mother at each trimester and from cord blood at delivery. mRNA and protein expression levels were evaluated with real-time RT-PCR and Western blotting. Lipoprotein lipase (LPL) activity was evaluated using enzyme fluorescence. In vitro linoleic acid transport was studied with isolated trophoblasts. Our results demonstrated that maternal obesity is associated with increased placental weight, decreased gestational age, decreased maternal high-density lipoprotein (HDL) levels during the first and third trimesters, increased maternal triglyceride levels during the second and third trimesters, and increased maternal T3 levels during all trimesters, and decreased maternal cholesterol (CHOL) and low-density lipoprotein (LDL) levels during the third trimester; and increased newborn CHOL, LDL, apolipoprotein B100, and T3 levels. Increases in placental CD36 mRNA and protein expression levels, decreased SLC27A4 and FABP1 mRNA and protein and FABP3 protein expression, and increased LPL activity and decreased villus cytotrophoblast linoleic acid transport were also observed. No changes were seen in expression of PPARA, PPARD, or PPARG mRNA and protein. Overall this study demonstrated that maternal obesity impacts placental FA uptake without affecting fetal growth. These changes, however, could modify the fetus metabolism and its predisposition to develop diseases later in life.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“There are also changes in placental fatty acid transport and transporter expression in obese relative to lean women irrespective of the weight of their infants (101, 156).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [156]
Citations
Cites
Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038
Prevalence and Trends in Obesity Among US Adults, 1999-2008
Flegal, K. M. (2010) · JAMA · doi:10.1001/jama.2009.2014 · Cited by 7,580
Wang, Y., Beydoun, M. A., Liang, L., Caballero, B. H., & Kumanyika, S. (2008) · Obesity · doi:10.1038/oby.2008.351 · Cited by 1,565
CD36 is a receptor for oxidized low density lipoprotein
Endemann, G., Stanton, L. W., Madden, K. S., Bryant, C. M., White, R. T., & Protter, A. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50272-1 · Cited by 1,282
Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein
Schaffer, J. E., & Lodish, H. F. (1994) · Cell · doi:10.1016/0092-8674(94)90252-6 · Cited by 868
Lipoprotein lipase: from gene to obesity
Wang, H., & Eckel, R. H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90920.2008 · Cited by 741
Obesity in Pregnancy Stimulates Macrophage Accumulation and Inflammation in the Placenta
Challier, J. C., Basu, S., Bintein, T., Minium, J., Hotmire, K., Catalano, P. M., & Hauguel-de Mouzon, S. (2008) · Placenta · doi:10.1016/j.placenta.2007.12.010 · Cited by 712 · cited 1×
“Studies have reported mostly inflammatory changes in the placenta of obese women, such as an accumulation of immune cells (macrophages and neutrophils) and an increase in the expression of several inflammatory cytokines (interleukin-1 [IL-1], IL-6, tumor necrosis factor-a [TNF-a], IL-8) [40, 43, 44].”
BackgroundOsmond, C., & Barker, D. J. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108s3545 · Cited by 668
Maternal Obesity Is Associated with Dysregulation of Metabolic, Vascular, and Inflammatory Pathways
Ramsay, J. E., Ferrell, W. R., Crawford, L., Wallace, A. M., Greer, I. A., & Sattar, N. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020311 · Cited by 659
Obesity and reproductive disorders in women
Pasquali, R. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg024 · Cited by 549
Research works printed but not linked: 1
- 2012, Global Database on Body Mass Index: An Interactive Surveillance Tool for Monitoring Nutrition Transition
Cited by
Sorted by citations
Catalano, P. M., & Shankar, K. (2017) · BMJ · doi:10.1136/bmj.j1 · Cited by 1,306
Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717
Maternal–Fetal Nutrient Transport in Pregnancy Pathologies: The Role of the Placenta
Brett, K., Ferraro, Z. M., Yockell‐Lelièvre, J., Gruslin, A., & Adamo, K. B. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150916153 · Cited by 459
Jansson, N., Rosario, F. J., Gaccioli, F., Lager, S., Jones, H. N., Roos, S., Jansson, T., & Powell, T. L. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2667 · Cited by 305
Maternal obesity is associated with a lipotoxic placental environment
Saben, J. L., Lindsey, F., Zhong, Y., Thakali, K. M., Badger, T. M., Andres, A., Gómez-Acevedo, H., & Shankar, K. (2014) · Placenta · doi:10.1016/j.placenta.2014.01.003 · Cited by 307
Metadata
- Authors
- Dubé, E., Gravel, A., Martin, C., Desparois, G., Moussa, I., Ethier-Chiasson, M., Forest, J.-C., Giguère, Y., Masse, A., & Lafond, J.
- Affiliations
- Université du Québec à Montréal (CA)
- Hôpital Saint-François d'Assise (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- Corresponding author
- Lafond, Julie
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-07-01
- Volume
- 87
- Issue
- 1
- Pages
- 14, 1-11
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2113432131
- Cited by
- 180
- References
- 83
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 9 · 2021: 14 · 2020: 15 · 2019: 18 · 2018: 17 · 2017: 23 · 2016: 20 · 2015: 15 · 2014: 11 · 2013: 10 · 2012: 3
- FWCI
- 15.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biology of Reproduction (publishedVersion)
- PubMed (publishedVersion)
- BioOne Complete (BioOne) (submittedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- maternal obesity, placenta, fatty acid uptake, fatty acid metabolism, CD36, SLC27A4, FABP1, FABP3, lipoprotein lipase, trophoblast, HDL cholesterol, triglycerides, thyroid hormones, peroxisome proliferator-activated receptors, umbilical cord blood, fetal programming, body mass index
- MeSH terms
- Fatty Acid Binding Protein 3, Base Sequence, Biological Transport, Active, Fatty Acids, Female, Hormones, Humans, Infant, Newborn, Lipids, Lipoprotein Lipase, Maternal-Fetal Exchange, Models, Biological, Obesity, Placenta, Pregnancy, Pregnancy Complications, Case-Control Studies, DNA Primers, CD36 Antigens, Linoleic Acid, Peroxisome Proliferator-Activated Receptors, Fatty Acid-Binding Proteins, Fatty Acid Transport Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
