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Modulation of Fatty Acid Transport and Metabolism by Maternal Obesity in the Human Full-Term Placenta1
Abstract
Knowledge of the consequences of maternal obesity in human placental fatty acids (FA) transport and metabolism is limited. Animal studies suggest that placental uptake of maternal FA is altered by maternal overnutrition. We hypothesized that high maternal body mass index (BMI) affects human placental FA transport by modifying expression of key transporters. Full-term placentas were obtained by vaginal delivery from normal weight (BMI, 18.5-24.9 kg/m(2)) and obese (BMI > 30 kg/m(2)) women. Blood samples were collected from the mother at each trimester and from cord blood at delivery. mRNA and protein expression levels were evaluated with real-time RT-PCR and Western blotting. Lipoprotein lipase (LPL) activity was evaluated using enzyme fluorescence. In vitro linoleic acid transport was studied with isolated trophoblasts. Our results demonstrated that maternal obesity is associated with increased placental weight, decreased gestational age, decreased maternal high-density lipoprotein (HDL) levels during the first and third trimesters, increased maternal triglyceride levels during the second and third trimesters, and increased maternal T3 levels during all trimesters, and decreased maternal cholesterol (CHOL) and low-density lipoprotein (LDL) levels during the third trimester; and increased newborn CHOL, LDL, apolipoprotein B100, and T3 levels. Increases in placental CD36 mRNA and protein expression levels, decreased SLC27A4 and FABP1 mRNA and protein and FABP3 protein expression, and increased LPL activity and decreased villus cytotrophoblast linoleic acid transport were also observed. No changes were seen in expression of PPARA, PPARD, or PPARG mRNA and protein. Overall this study demonstrated that maternal obesity impacts placental FA uptake without affecting fetal growth. These changes, however, could modify the fetus metabolism and its predisposition to develop diseases later in life.
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“There are also changes in placental fatty acid transport and transporter expression in obese relative to lean women irrespective of the weight of their infants (101, 156).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [156]
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Metadata
- Authors
- Dubé, E., Gravel, A., Martin, C., Desparois, G., Moussa, I., Ethier-Chiasson, M., Forest, J.-C., Giguère, Y., Masse, A., & Lafond, J.
- Affiliations
- Université du Québec à Montréal (CA)
- Hôpital Saint-François d'Assise (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- Corresponding author
- Lafond, Julie
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-07-01
- Volume
- 87
- Issue
- 1
- Pages
- 14, 1-11
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2113432131
- Cited by
- 180
- References
- 83
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 9 · 2021: 14 · 2020: 15 · 2019: 18 · 2018: 17 · 2017: 23 · 2016: 20 · 2015: 15 · 2014: 11 · 2013: 10 · 2012: 3
- FWCI
- 15.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biology of Reproduction (publishedVersion)
- PubMed (publishedVersion)
- BioOne Complete (BioOne) (submittedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- maternal obesity, placenta, fatty acid uptake, fatty acid metabolism, CD36, SLC27A4, FABP1, FABP3, lipoprotein lipase, trophoblast, HDL cholesterol, triglycerides, thyroid hormones, peroxisome proliferator-activated receptors, umbilical cord blood, fetal programming, body mass index
- MeSH terms
- Fatty Acid Binding Protein 3, Base Sequence, Biological Transport, Active, Fatty Acids, Female, Hormones, Humans, Infant, Newborn, Lipids, Lipoprotein Lipase, Maternal-Fetal Exchange, Models, Biological, Obesity, Placenta, Pregnancy, Pregnancy Complications, Case-Control Studies, DNA Primers, CD36 Antigens, Linoleic Acid, Peroxisome Proliferator-Activated Receptors, Fatty Acid-Binding Proteins, Fatty Acid Transport Proteins
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