Placental fatty acid transport in maternal obesity
Abstract
Pregestational obesity is a significant risk factor for adverse pregnancy outcomes. Maternal obesity is associated with a specific proinflammatory, endocrine and metabolic phenotype that may lead to higher supply of nutrients to the feto-placental unit and to excessive fetal fat accumulation. In particular, obesity may influence placental fatty acid (FA) transport in several ways, leading to increased diffusion driving force across the placenta, and to altered placental development, size and exchange surface area. Animal models show that maternal obesity is associated with increased expression of specific FA carriers and inflammatory signaling molecules in placental cotyledonary tissue, resulting in enhanced lipid transfer across the placenta, dislipidemia, fat accumulation and possibly altered development in fetuses. Cell culture experiments confirmed that inflammatory molecules, adipokines and FA, all significantly altered in obesity, are important regulators of placental lipid exchange. Expression studies in placentas of obese–diabetic women found a significant increase in FA binding protein-4 expression and in cellular triglyceride content, resulting in increased triglyceride cord blood concentrations. The expression and activity of carriers involved in placental lipid transport are influenced by the endocrine, inflammatory and metabolic milieu of obesity, and further studies are needed to elucidate the strong association between maternal obesity and fetal overgrowth.
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There are changes in placental fatty acid transport and transporter expression in obese relative to lean women irrespective of the weight of their infants.
“There are also changes in placental fatty acid transport and transporter expression in obese relative to lean women irrespective of the weight of their infants (101, 156).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [101]
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Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works
- Authors
- Cetin, I., Parisi, F., Berti, C., Mandò, C., & Desoye, G.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Cetin, I.
- Venue
- Journal of Developmental Origins of Health and Disease
- Publisher
- Cambridge University Press (CUP)
- Published
- 2012-06-14
- Volume
- 3
- Issue
- 6
- Pages
- 409-414
- ISSN
- 2040-1744 (ISSN-L)
- 2040-1752
- OpenAlex
- W2123209481
- Cited by
- 45
- References
- 57
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 4 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 7 · 2014: 3
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Developmental Origins of Health and Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Oesterreichische Nationalbank
- Fondazione Romeo ed Enrica Invernizzi
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- maternal obesity, fetal overgrowth, adipokines, placental inflammation, placental development, triglyceride transport, gestational diabetes mellitus, placental cotyledons
- MeSH terms
- Biological Transport, Fatty Acids, Female, Humans, Maternal-Fetal Exchange, Obesity, Placenta, Pregnancy, Pregnancy Complications, Lipid Metabolism
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