The role of hypoxia and hypoxia-inducible factor-1alpha in preeclampsia pathogenesis

Tal, Reshef

doi:10.1095/biolreprod.112.102723

Cited by 235Pregnancy and preeclampsia studiesNeurological Complications and SyndromesReproductive System and Pregnancy

The role of hypoxia and hypoxia-inducible factor-1alpha in preeclampsia pathogenesis

Tal, Reshef·2012·Biology of Reproduction

DOI 10.1095/biolreprod.112.102723

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Abstract

Preeclampsia affects 5%-8% of pregnancies and is the leading worldwide cause of maternal and fetal morbidity and mortality. Preeclampsia is associated with shallow trophoblast invasion and inadequate spiral artery remodeling, which are widely believed to lead to placental hypoxia, the putative culprit initiating the cascade of events that ultimately results in the maternal manifestations of the disease. Despite extensive research, however, the pathophysiology of this disease remains poorly understood, no effective prevention exists, and treatment is limited to symptomatic therapy. Recent research has introduced exciting new theories regarding the pathogenesis of preeclampsia. Clinical and experimental evidence implicating the circulating antiangiogenic molecules soluble Fms-like tyrosine kinase-1 (sFLT-1) and soluble endoglin (sENG), as well as endothelin-1 and the angiotensin II receptor type I autoimmune antibody (AT-1AA), have been especially promising. This review collates evidence for a role of hypoxia and hypoxia-inducible factor-1alpha (HIF1A; referred to as HIF-1α throughout) in the pathogenesis of preeclampsia and discusses possible molecular links between hypoxia and the newly reported potential mediators of the disease's manifestations.

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Succinate is also an inhibitor of HIF-1α, which has been implicated in the exaggerated production of sFlt-1 and in the pathophysiology of preeclampsia.
“However, succinate is also an inhibitor of HIF-1α(213), which has been implicated in the exaggerated production of sFlt-1 and in the pathophysiology of preeclampsia(214, 215)”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [215]

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Authors: Tal, R.
Affiliations: Maimonides Medical Center (US)
Corresponding author: Tal, Reshef
ORCID: Tal, Reshef
Venue: Biology of Reproduction
Publisher: Oxford University Press (OUP)
Published: 2012-12-01
Volume: 87
Issue: 6
Pages: 134-134
ISSN: 0006-3363 (ISSN-L)
1529-7268
DOI: 10.1095/biolreprod.112.102723
OpenAlex: W2148108051
Cited by: 235
References: 115
Citations by year: 2026: 15 · 2025: 14 · 2024: 20 · 2023: 11 · 2022: 17 · 2021: 20 · 2020: 20 · 2019: 14 · 2018: 21 · 2017: 20 · 2016: 18 · 2015: 17 · 2014: 22 · 2013: 6
FWCI: 2.35
Type: journal article
Language: en
Open access: closed
Locations: Biology of Reproduction (publishedVersion)
PubMed (publishedVersion)
BioOne Complete (BioOne) (submittedVersion)
Topics: Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Keywords: preeclampsia, hypoxia, hypoxia-inducible factor-1α, placental hypoxia, trophoblast invasion, spiral artery remodeling, soluble fms-like tyrosine kinase-1, soluble endoglin, endothelin-1, preeclampsia pathogenesis
MeSH terms: Endoglin, Animals, Autoantibodies, Female, Humans, Placenta, Pre-Eclampsia, Pregnancy, Receptors, Cell Surface, Solubility, Cell Hypoxia, Antigens, CD, Endothelin-1, Vascular Endothelial Growth Factor Receptor-1, Receptor, Angiotensin, Type 1, Hypoxia-Inducible Factor 1, alpha Subunit

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The role of hypoxia and hypoxia-inducible factor-1alpha in preeclampsia pathogenesis

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