Regulation of androgen action during establishment of pregnancy
Open accessAbstract
During the establishment of pregnancy, the ovarian-derived hormones progesterone and oestradiol regulate remodelling of the endometrium to promote an environment that is able to support and maintain a successful pregnancy. Decidualisation is characterised by differentiation of endometrial stromal cells that secrete growth factors and cytokines that regulate vascular remodelling and immune cell influx. This differentiation process is critical for reproduction, and inadequate decidualisation is implicated in the aetiology of pregnancy disorders such as foetal growth restriction and preeclampsia. In contrast to progesterone and oestradiol, the role of androgens in regulating endometrial function is poorly understood. Androgen receptors are expressed in the endometrium, and androgens are reported to regulate both the transcriptome and the secretome of endometrial stromal cells. In androgen-target tissues, circulating precursors are activated to mediate local effects, and recent studies report that steroid concentrations detected in endometrial tissue are distinct to those detected in the peripheral circulation. New evidence suggests that decidualisation results in dynamic changes in the expression of androgen biosynthetic enzymes, highlighting a role for pre-receptor regulation of androgen action during the establishment of pregnancy. These results suggest that such enzymes could be future therapeutic targets for the treatment of infertility associated with endometrial dysfunction. In conclusion, these data support the hypothesis that androgens play a beneficial role in regulating the establishment and maintenance of pregnancy. Future studies should be focussed on investigating the safety and efficacy of androgen supplementation with the potential for utilisation of novel therapeutics, such as selective androgen receptor modulators, to improve reproductive outcomes in women.
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Local intracrine biosynthesis of androgens may play a critical role in maintenance of a decidual phenotype, with addition of flutamide reducing biosynthesis of the decidualisation marker IGFBP1.
“Complementary studies by Gibson et al. [43], in which primary cells were stimulated to decidualise, showed local intracrine biosynthesis of androgens may play a critical role in maintenance of a decidual phenotype, with addition of flutamide reducing biosynthesis of the decidualisation marker IGFBP1 [43,59].”
From Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders (2018) · cites this paper as [59]
The R41 Review section reports local androgen biosynthesis during decidualisation of human endometrial stromal cells and a significant decrease in IGFBP1 expression when intracrine androgen signalling was blocked. However, this paper reviews those findings from Gibson et al. (2016) rather than presenting the primary-cell experiment itself; it reports reduced IGFBP1 expression, not a direct measurement of IGFBP1 biosynthesis. (LLM, conf=0.86)
Experimental — accuracy not yet measuredBoth local activation and metabolism of androgens occur during decidualisation, and temporal regulation of intracrine androgen bioavailability is a critical mediator of endometrial competence during remodelling required for establishment of pregnancy.
“Taken together, these studies suggest both local activation and metabolism of androgens occur during decidualisation and that temporal regulation of intracrine androgen bioavailability is a critical mediator of endometrial competence during remodelling required for establishment of pregnancy [39,59].”
From Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders (2018) · cites this paper as [59]
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Cites
Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones
Payne, A. H., & Hales, D. B. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0030 · Cited by 1,766 · see citing works
Cyclic Decidualization of the Human Endometrium in Reproductive Health and Failure
Gellersen, B., & Brosens, J. J. (2014) · Endocrine Reviews · doi:10.1210/er.2014-1045 · Cited by 1,151 · see citing works
Immunology of placentation in eutherian mammals
Moffett, A., & Loke, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1897 · Cited by 843 · see citing works
Burger, H. G. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)02985-0 · Cited by 771 · cited 1× · see citing works
“Circulating concentrations of androgens remain relatively constant throughout the menstrual cycle, exceeding those of oestrogens (Burger 2002, Rothman et al.”
BackgroundLabrie, F. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90116-a · Cited by 685 · see citing works
Yeh, S., Tsai, M.-Y., Xu, Q., Mu, X., Lardy, H. A., Huang, K., Lin, H., Yeh, S.-D., Altuwaijri, S., Zhou, X., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212474399 · Cited by 668 · see citing works
Ruíz-Alonso, M., Blesa, D., Díaz-Gimeno, P., Gómez, E., Sánchez, M. F., Carranza, F., Carrera, J., Vilella, F., Pellicer, A., & Simón, C. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.05.004 · Cited by 561 · see citing works
Ma, W., Song, H., Das, S. K., Paria, B. C., & Dey, S. K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530162100 · Cited by 544 · see citing works
Hormonal Control of Ovoimplantation
Psychoyos, A. (1974) · Vitamins and hormones · doi:10.1016/s0083-6729(08)60999-1 · Cited by 481 · see citing works
Robb, L., Li, R., Hartley, L., Nandurkar, H. H., Köentgen, F., & Begley, C. G. (1998) · Nature Medicine · doi:10.1038/nm0398-303 · Cited by 468 · see citing works
Ovarian and adrenal contribution to peripheral androgens during the menstrual cycle
ABRAHAM, G. E. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-39-2-340 · Cited by 436 · see citing works
Zumoff, B., Strain, G. W., Miller, L. K., & Rosner, W. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.4.7714119 · Cited by 392 · see citing works
Premature ovarian failure in androgen receptor-deficient mice
Shiina, H., Μatsumoto, T., Sato, T., Igarashi, K., Miyamoto, J., Takemasa, S., Sakari, M., Takada, I., Nakamura, T., METZGER, D., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506736102 · Cited by 332 · see citing works
Uterine leukocytes and decidualization
King, A. (2000) · Human Reproduction Update · doi:10.1093/humupd/6.1.28 · Cited by 332 · see citing works
The impact of embryonic development and endometrial maturity on the timing of implantation
Bergh, P. A., & Navot, D. (1992) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55259-5 · Cited by 328 · see citing works
The Human Endometrium as a Sensor of Embryo Quality1
Macklon, N., & Brosens, J. J. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.114.122846 · Cited by 320 · see citing works
Kimura, N., Mizokami, A., Oonuma, T., Sasano, H., & Nagura, H. (1993) · Journal of Histochemistry & Cytochemistry · doi:10.1177/41.5.8468448 · Cited by 298 · see citing works
Length of human pregnancy and contributors to its natural variation
Jukic, A. M. Z., Baird, D. D., Weinberg, C. R., McConnaughey, D. R., & Wilcox, A. J. (2013) · Human Reproduction · doi:10.1093/humrep/det297 · Cited by 298 · see citing works
Elevated Endometrial Androgen Receptor Expression in Women with Polycystic Ovarian Syndrome1
Apparao, K. B. C., Lovely, L. P., Gui, Y., Lininger, R. A., & Lessey, B. A. (2002) · Biology of Reproduction · doi:10.1095/biolreprod66.2.297 · Cited by 265 · see citing works
Rothman, M. S., Carlson, N. E., Xu, M., Wang, C., Swerdloff, R., Lee, P., Goh, V. H. H., Ridgway, E. C., & Wierman, M. E. (2011) · Steroids · doi:10.1016/j.steroids.2010.10.010 · Cited by 248 · see citing works
Decidualization of the human endometrial stromal cell: an enigmatic transformation
Dunn, C. L., KELLY, R. W., & Critchley, H. (2003) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)61745-2 · Cited by 245 · see citing works
Diverse roles of androgen receptor (AR) domains in AR-mediated signaling
Claessens, F., Denayer, S., Tilborgh, N. V., Kerkhofs, S., Helsen, C., & Haelens, A. (2008) · Nuclear Receptor Signaling · doi:10.1621/nrs.06008 · Cited by 232 · see citing works
Labrie, F. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.06.001 · Cited by 227 · see citing works
Molecular aspects of implantation failure
Koot, Y. E., Teklenburg, G., Salker, M. S., Brosens, J. J., & Macklon, N. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.05.017 · Cited by 222 · see citing works
Okon, M. A., Laird, S. M., Tuckerman, E. M., & Li, T. C. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00007-7 · Cited by 220 · see citing works
Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism
Rižner, T. L., & Penning, T. M. (2014) · Steroids · doi:10.1016/j.steroids.2013.10.012 · Cited by 217 · see citing works
Casey, M. L., MacDonald, P. C., & Andersson, S. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117569 · Cited by 212 · see citing works
Modulation of Androgen Receptor Activation Function 2 by Testosterone and Dihydrotestosterone
Askew, E. B., Gampe, R. T., Stanley, T. B., Faggart, J. L., & Wilson, E. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703268200 · Cited by 208 · see citing works
Attar, E., Tokunaga, H., Imir, G., Yilmaz, M. B., Redwine, D., Putman, M., Gurates, B., Attar, R., Yaegashi, N., Hales, D. B., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1180 · Cited by 207 · see citing works
Barad, D., Brill, H., & Gleicher, N. (2007) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-007-9178-x · Cited by 207 · see citing works
Huhtinen, K., Desai, R., Ståhle, M., Salminen, A., Handelsman, D. J., Perheentupa, A., & Poutanen, M. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1154 · Cited by 195 · see citing works
Profiling the gene signature of endometrial receptivity: clinical results
Garrido‐Gómez, T., Ruíz-Alonso, M., Blesa, D., Díaz-Gimeno, P., Vilella, F., & Simón, C. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.12.005 · Cited by 189 · see citing works
Aghajanova, L., Hamilton, A., Kwintkiewicz, J., Vo, K. C., & Giudice, L. C. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.108.070300 · Cited by 168 · see citing works
STRUCTURAL ORGANIZATION OF THE HUMAN ANDROGEN RECEPTOR GENE
Kuiper, G. G. J. M., Faber, P. W., van Rooij, H. C. J., et al. (1989) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.002r001 · Cited by 168 · see citing works
Do androgens have a direct effect on endometrial function? An in vitro study
Tuckerman, E. M., Okon, M. A., Li, T.-C., & Laird, S. M. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(00)00711-1 · Cited by 167 · see citing works
Cloke, B., Huhtinen, K., Fusi, L., Kajihara, T., Yliheikkilä, M., Ho, K.-K., Teklenburg, G., Lavery, S., Jones, M. C., Trew, G., et al. (2008) · Endocrinology · doi:10.1210/en.2008-0356 · Cited by 159 · see citing works
Tsai, S.-J., Wu, M.-H., Lin, C.-C., Sun, H. S., & Chen, H.-M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8082 · Cited by 155 · see citing works
Walters, K. A., Allan, C. M., Jimenez, M., Lim, P., Davey, R. A., Zajac, J. D., Illingworth, P. J., & Handelsman, D. J. (2007) · Endocrinology · doi:10.1210/en.2007-0248 · Cited by 147 · see citing works
Perrone, A. M., Cerpolini, S., Salfi, N., Ceccarelli, C., Giorgi, L. B. D., Formelli, G., Casadio, P., Ghi, T., Pelusi, G., Pelusi, C., et al. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01380.x · Cited by 143 · see citing works
Mertens, H. J. M. M., Heineman, M. J., Theunissen, P. H. M. H., et al. (2001) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(00)00554-6 · Cited by 143 · see citing works
Horie, K., Takakura, K., Imai, K., Liao, S., & Mori, T. (1992) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137595 · Cited by 140 · see citing works
Laws, M. J., Taylor, R. N., Sidell, N., DeMayo, F. J., Lydon, J. P., Gutstein, D. E., Bagchi, M. K., & Bagchi, I. C. (2008) · Development · doi:10.1242/dev.019810 · Cited by 140 · see citing works
Slayden, O. D., Nayak, N. R., Burton, K. A., Chwalisż, K., Cameron, S. T., Critchley, H., Baird, D. T., & Brenner, R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.6.7606 · Cited by 140 · see citing works
Androgen actions in the ovary: balance is key
Prizant, H., Gleicher, N., & Sen, A. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0296 · Cited by 136 · see citing works
Hormone receptor dynamics in a receptive human endometrium
Critchley, H. O. D., & Saunders, P. T. K. (2009) · Reproductive Sciences · doi:10.1177/1933719108331121 · Cited by 133 · see citing works
Self-citationDas, A., Mantena, S. R., Kannan, A., Evans, D. B., Bagchi, M. K., & Bagchi, I. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901647106 · Cited by 131 · see citing works
Hypoandrogenism in association with diminished functional ovarian reserve
Gleicher, N., Kim, A., Weghofer, A., Kushnir, V. A., Shohat-Tal, A., Lazzaroni, E., Lee, H., & Barad, D. H. (2013) · Human Reproduction · doi:10.1093/humrep/det033 · Cited by 130 · see citing works
Cornillie, F. J., Lauweryns, J. M., & Brosens, I. A. (2010) · Gynecologic and Obstetric Investigation · doi:10.1159/000298983 · Cited by 118 · see citing works
Ruíz-Alonso, M., Galindo, N., Pellicer, A., et al. (2014) · Human Reproduction · doi:10.1093/humrep/deu070 · Cited by 114 · see citing works
Visualising androgen receptor activity in male and female mice
Dart, D. A., Waxman, J., Aboagye, E. O., & Bevan, C. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071694 · Cited by 112 · see citing works
Decidualisation and angiogenesis
Plaisier, M. (2010) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2010.10.011 · Cited by 111 · see citing works
Kajihara, T., Tanaka, K., Oguro, T., Tochigi, H., Prechapanich, J., Uchino, S., Itakura, A., Šućurović, S., Murakami, K., Brosens, J. J., et al. (2013) · Reproductive Sciences · doi:10.1177/1933719113497280 · Cited by 110 · see citing works
The cell biology of human implantation
Aplin, J. (1996) · Placenta · doi:10.1016/s0143-4004(96)90050-8 · Cited by 109 · see citing works
Gibson, D. A., Greaves, E., Critchley, H. O. D., & Saunders, P. T. K. (2015) · Human Reproduction · doi:10.1093/humrep/dev067 · Cited by 108 · see citing works
Self-citationParia, B. C., Lim, H. J., Wang, X., Liehr, J. G., Das, S. K., & Dey, S. K. (1998) · Endocrinology · doi:10.1210/endo.139.12.6386 · Cited by 104 · see citing works
Walters, K. A., McTavish, K. J., Seneviratne, M. G., Jimenez, M., McMahon, A. C., Allan, C. M., Salamonsen, L. A., & Handelsman, D. J. (2009) · Endocrinology · doi:10.1210/en.2008-1750 · Cited by 100 · see citing works
Kara, M., Aydın, T., Aran, T., Türktekin, N., & Özdemir, B. H. (2013) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2013.11.008 · Cited by 96 · see citing works
Chadha, S., Pache, T. D., Huikeshoven, F. J. M., Brinkmann, A. O., & van derKwast, T. H. (1994) · Human Pathology · doi:10.1016/0046-8177(94)90037-x · Cited by 94 · see citing works
Evidence for diminished midcycle ovarian androgen production in older reproductive aged women
Mushayandebvu, T., Castracane, V. D., Gimpel, T., Adel, T., & Santoro, N. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58203-x · Cited by 94 · see citing works
Expression of androgen receptor and 5α‐reductases in the human normal endometrium and its disorders
Ito, K., Suzuki, T., Akahira, J., Moriya, T., Kaneko, C., Utsunomiya, H., Yaegashi, N., Okamura, K., & Sasano, H. (2002) · International Journal of Cancer · doi:10.1002/ijc.10394 · Cited by 88 · see citing works
Review: The role of leukaemia inhibitory factor in the establishment of pregnancy
Vogiagis, D., & Salamonsen, L. A. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600181 · Cited by 84 · see citing works
Gibson, D. A., Simitsidellis, I., Cousins, F. L., Critchley, H. O. D., & Saunders, P. T. K. (2016) · Scientific Reports · doi:10.1038/srep19970 · Cited by 82 · see citing works
Self-citationSlayden, O. D. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.6.2668 · Cited by 79 · see citing works
Huhtinen, K., Saloniemi-Heinonen, T., Keski-Rahkonen, P., Desai, R., Laajala, D., Ståhle, M., Häkkinen, M. R., Awosanya, M., Suvitie, P., Kujari, H., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1913 · Cited by 75 · see citing works
Low-Dose Mifepristone Inhibits Endometrial Proliferation and Up-Regulates Androgen Receptor
Narvekar, N. N., Cameron, S. T., Critchley, H., Lin, S., Cheng, L., & Baird, D. T. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031945 · Cited by 74 · see citing works
Karpovich, N., Klemmt, P. A. B., Hwang, J. H., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0868 · Cited by 73 · see citing works
Marshall, E., Lowrey, J., MacPherson, S., Maybin, J. A., Collins, F., Critchley, H. O. D., & Saunders, P. T. K. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0272 · Cited by 66 · see citing works
Self-citationYu, J., Wu, J., Bagchi, I. C., Bagchi, M. K., Sidell, N., & Taylor, R. N. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.04.011 · Cited by 65 · see citing works
Catalano, R. D., Wilson, M. R., Boddy, S. C., & Jabbour, H. N. (2011) · Molecular Human Reproduction · doi:10.1093/molehr/gaq094 · Cited by 62 · see citing works
Milne, S. A., Henderson, T. A., KELLY, R. W., Saunders, P. T. K., Baird, D. T., & Critchley, H. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2338 · Cited by 59 · see citing works
Self-citationHukkanen, J., Mäntylä, M., Kangas, L., et al. (1998) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1998.tb01404.x · Cited by 59 · see citing works
Importance of Periodontal Disease in the Kidney Patient
Craig, R. G., Spittle, M. A., & Levin, N. W. (2002) · Blood Purification · doi:10.1159/000046994 · Cited by 59 · see citing works
Gleicher, N., Kim, A., Weghofer, A., Shohat-Tal, A., Lazzaroni, E., Lee, H., & Barad, D. H. (2012) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-012-9890-z · Cited by 56 · see citing works
Li, J., Yuan, H., Chen, Y., Wu, H., Wu, H., & Li, L. (2015) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2015.06.028 · Cited by 55 · see citing works
Androgens induce prolactin production by human endometrial stromal cells in vitro
Narukawa, S., Kanzaki, H., Inoue, T. K., Imai, K., Higuchi, T., Hatayama, H., Kariya, M., & Mori, T. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.1.8288699 · Cited by 55 · see citing works
Flutamide Counteracts the Antiproliferative Effects of Antiprogestins in the Primate Endometrium
Slayden, O. D., & Brenner, R. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021763 · Cited by 49 · see citing works
Effects of androgen on embryo implantation in the mouse delayed-implantation model
Diao, H., Su, R., Tan, H., Li, S.-J., Lei, W., Deng, W.-B., & Yang, Z. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.07.1341 · Cited by 49 · see citing works
Kajihara, T., Tochigi, H., Prechapanich, J., Uchino, S., Itakura, A., Brosens, J. J., & Ishihara, O. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.10.017 · Cited by 49 · see citing works
Hevir, N., Vouk, K., Šinkovec, J., Ribič-Pucelj, M., & Lanišnik Rižner, T. (2011) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2011.01.003 · Cited by 48 · see citing works
Gibson, D. A., McInnes, K. J., Critchley, H. O. D., & Saunders, P. T. K. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2140 · Cited by 44 · see citing works
Self-citationYen, P. M., Liu, Y., Palvimo, J. J., Trifiro, M. A., Whang, J., Pinsky, L., Jänne, O. A., & Chin, W. W. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.2.9886 · Cited by 41 · see citing works
Bukulmez, O., Hardy, D., Carr, B. R., Auchus, R., Toloubeydokhti, T., Word, R., & Mendelson, C. R. (2008) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2008-0248 · Cited by 40 · see citing works
Androgen receptor and 5α‐reductase are expressed in pelvic endometriosis
Carneiro, M. M., Morsch, D. M., Camargos, A. F., dos Reis, F. M., & Spritzer, P. M. (2007) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2007.01521.x · Cited by 37 · see citing works
Impact of ovulation and implantation timing on first‐trimester crown–rump length and gestational age
Mahendru, A. A., Daemen, A., Everett, T. R., Wilkinson, I. B., McEniery, C. M., Abdallah, Y., Timmerman, D., Bourne, T., & Lees, C. C. (2012) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.12277 · Cited by 34 · see citing works
Paria, B. C. (1998) · Endocrinology · doi:10.1210/en.139.12.5235 · Cited by 34 · see citing works
A study of recipient related predictors of success in oocyte donation program
Gupta, P., Banker, M., Patel, P. M., et al. (2012) · Journal of Human Reproductive Sciences · doi:10.4103/0974-1208.106336 · Cited by 29 · see citing works
Rhee, H. S., Oh, S. H., Ko, B. J., Han, D. M., Jeon, B. H., Park, H., Moon, H. B., & Kim, W. S. (2003) · Experimental & Molecular Medicine · doi:10.1038/emm.2003.22 · Cited by 28 · see citing works
Dehydroepiandrosterone supplementation increases baseline follicular phase progesterone levels
Weissman, A., Horowitz, E., Ravhon, A., Golan, A., & Levran, D. (2011) · Gynecological Endocrinology · doi:10.3109/09513590.2011.569611 · Cited by 27 · see citing works
Maintenance of Decidual Cell Reaction by Androgens in the Mouse1
Zhang, X., & Croy, B. A. (1996) · Biology of Reproduction · doi:10.1095/biolreprod55.3.519 · Cited by 27 · see citing works
Choi, J. P., Zheng, Y., Giles, K. A., Handelsman, D. J., & Simanainen, U. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.115.132241 · Cited by 27 · see citing works
Regulation of Uterine 5α-Reductase Type 1 in Mice1
Minjarez, D. A., Konda, V. J. A., & Word, R. A. (2001) · Biology of Reproduction · doi:10.1095/biolreprod65.5.1378 · Cited by 11 · see citing works
Chen, Y., Saini, S., Zaman, M. S., Hirata, H., Shahryari, V., Deng, G., & Dahiya, R. (2010) · Molecular Carcinogenesis · doi:10.1002/mc.20680 · Cited by 8 · see citing works
(2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908998106 · Cited by 7 · see citing works
Reduction of Testosterone to 5α-Dihydrotestosterone by Human and Rat Uterine Tissues*
Rose, L. I., Reddy, V. V. R., & Biondi, R. J. (1978) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-46-5-766 · Cited by 6 · see citing works
Flagged first, then by citations
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Sorted by citations
Androgens and endometrium: new insights and new targets
Simitsidellis, I., Saunders, P. T. K., & Gibson, D. A. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.09.022 · Cited by 107 · see citing works
Self-citationEndometriosis and polycystic ovary syndrome are diametric disorders
Dinsdale, N. L., & Crespi, B. J. (2021) · Evolutionary Applications · doi:10.1111/eva.13244 · Cited by 90 · see citing works
“…Increased Testosterone Produced by ovarian theca cells, regulates folliculogenesis and decidualization (Couse et al., 2006; Gervásio et al., 2014; Gibson et al., 2016) Decreased Increased Sex hormone- binding globulin Influences bioavailability of sex hormones (Goldštajn et al., 2016) Increased…”
BackgroundAndrogens, oestrogens and endometrium: a fine balance between perfection and pathology
Gibson, D. A., Simitsidellis, I., Collins, F., & Saunders, P. T. K. (2020) · Journal of Endocrinology · doi:10.1530/joe-20-0106 · Cited by 76 · see citing works
Self-citationEndometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders
Gibson, D. A., Simitsidellis, I., Collins, F., & Saunders, P. T. K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103276 · Cited by 70 · see citing works
Self-citationDehydroepiandrosterone enhances decidualization in women of advanced reproductive age
Gibson, D. A., Simitsidellis, I., Kelepouri, O., Critchley, H. O. D., & Saunders, P. T. K. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.12.024 · Cited by 51 · see citing works
Self-citationGibson, D. A., Foster, P. A., Simitsidellis, I., Critchley, H. O. D., Kelepouri, O., Collins, F., & Saunders, P. T. K. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0037 · Cited by 10 · see citing works
Self-citationSteroid hormone profiling reveals altered adrenal androgen production in endometriosis
Simitsidellis, I., Ainslie, R. J., Taylor, A. E., Gilligan, L. C., Shaheen, F., Blanke, S., Anderson, C., Hapangama, D., Arlt, W., Horne, A. W., et al. (2026) · European Journal of Endocrinology · doi:10.1093/ejendo/lvag109 · Cited by 1 · see citing works
Self-citation
- Authors
- Gibson, D. A., Simitsidellis, I., & Saunders, P. T. K.
- Affiliations
- Centre for Inflammation Research (GB)
- Corresponding author
- Gibson, Douglas A
- Venue
- Journal of Molecular Endocrinology
- Publisher
- Bioscientifica
- Published
- 2016-07
- Volume
- 57
- Issue
- 1
- Pages
- R35-R47
- ISSN
- 0952-5041 (ISSN-L)
- 1479-6813
- OpenAlex
- W2338239994
- Cited by
- 42
- References
- 94
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 6 · 2020: 4 · 2019: 1 · 2018: 5 · 2017: 2
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Molecular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Medical Research Council (MR/N024524/1, G1100356/1)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- androgens, androgen receptor, decidualization, endometrial stromal cells, androgen production, progesterone, estradiol, selective androgen receptor modulators, endometrial dysfunction, infertility, preeclampsia, fetal growth restriction
- MeSH terms
- Androgens, Animals, Decidua, Endometrium, Estradiol, Female, Gene Expression Regulation, Humans, Pregnancy, Receptors, Androgen, Reproduction, Steroids, Signal Transduction, Gene Expression Regulation, Enzymologic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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