Differential expression of estrogen receptor-α and -β and androgen receptor in the ovaries of marmosets and humans

Saunders, Philippa T.K.; Millar, Michael R.; Williams, Karin; Macpherson, Sheila; Harkiss, Diana; Anderson, Richard A.; Orr, Brigid; Groome, Nigel P.; Scobie, Graeme; Fraser, Hamish M.

doi:10.1095/biolreprod63.4.1098

Cited by 183Estrogen and related hormone effectsReproductive Biology and FertilityOvarian function and disorders

Differential expression of estrogen receptor-α and -β and androgen receptor in the ovaries of marmosets and humans

Saunders, Philippa T.K., Millar, Michael R., Williams, Karin, Macpherson, Sheila, Harkiss, Diana, Anderson, Richard A., Orr, Brigid, Groome, Nigel P. +2 more·2000·Biology of Reproduction

DOI 10.1095/biolreprod63.4.1098

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Abstract

Estrogens and androgens are essential for the maturation of the ovarian follicle and normal fertility in the female. We have used antibodies specific for both forms of estrogen receptor (alpha [ERalpha] and beta [ERbeta]) and androgen receptor (AR) to investigate the pattern of receptor expression in ovaries obtained from women and from a New World primate, the Common marmoset (Callthrix jacchus). On Western blots, three antibodies directed against different peptides within human ERbeta all recognized recombinant human (h) ERbeta but did not bind to recombinant hERalpha. The ERbeta protein was extracted from human ovary and prostate and marmoset ovary. In marmoset and human ovaries, ERbeta protein was detected in the nuclei of granulosa cells in all sizes of follicle (both before and after formation of the antrum), and it was also detected in thecal cells, corpora lutea, surface epithelium, and stroma. In contrast, ERalpha protein was not detected in the nuclei of granulosa cells in preantral follicles, was low/absent from stromal and thecal cells, but was expressed in granulosa cells of antral follicles and in the surface epithelium. The pattern of expression of AR protein more closely resembled that of ERbeta than ERalpha. In conclusion, three independent antibodies have demonstrated convincingly that ERbeta is expressed in a wide range of cells in the primate ovary. Granulosa cells in preantral follicles could contain ERbeta:beta dimers. In antral follicles, however, ERalpha is also expressed, and the formation of homo- or heterodimers containing ERalpha may influence the pattern of gene activation within these cells.

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Detailed immunohistochemical studies using fixed full-thickness endometrial tissues with validated antibodies have identified nuclear staining for AR, ERalpha and ERbeta in the human endometrium during the normal menstrual cycle.
“Detailed immunohistochemical studies using fixed full-thickness endometrial tissues in combination with validated antibodies [27] have identified nuclear staining for AR, ERalpha and ERbeta in the human endometrium during the normal menstrual cycle [16,18,28,29].”
From Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders (2018) · cites this paper as [27]
The Materials and Methods (pp. 1–2) describe validated receptor antibodies and fixed, paraffin-embedded ovarian tissue from women and marmosets. They do not describe full-thickness endometrial tissue, so the tissue specification attached to this citation is unsupported. The separate citations [16,18,28,29] are offered for the endometrial nuclear-staining finding. (LLM, conf=0.86)
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Authors: Saunders, P. T. K., Millar, M. R., Williams, K., Macpherson, S., Harkiss, D., Anderson, R. A., Orr, B., Groome, N. P., Scobie, G., & Fraser, H. M.
Affiliations: Oxford Brookes University (GB)
Corresponding author: Saunders, Philippa T.K.
ORCID: Saunders, Philippa T.K.
Williams, Karin
Anderson, Richard A.
Venue: Biology of Reproduction
Publisher: Oxford University Press (OUP)
Published: 2000-10-01
Volume: 63
Issue: 4
Pages: 1098-1105
ISSN: 0006-3363 (ISSN-L)
1529-7268
DOI: 10.1095/biolreprod63.4.1098
OpenAlex: W1971365457
Cited by: 175
References: 49
Citations by year: 2025: 2 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 6 · 2015: 6 · 2014: 6 · 2013: 2 · 2012: 2
FWCI: 9.36
Type: journal article
Language: en
Open access: closed
Locations: Biology of Reproduction (publishedVersion)
PubMed (publishedVersion)
BioOne Complete (BioOne) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords: estrogen receptor alpha, estrogen receptor beta, androgen receptor, marmoset, Callithrix jacchus, human ovary, granulosa cells, theca cells, corpus luteum, ovarian follicle maturation, receptor heterodimers, antibody specificity
MeSH terms: Amino Acid Sequence, Animals, Antibody Specificity, Callithrix, Female, Gene Expression Regulation, Ovarian Follicle, Humans, Molecular Sequence Data, Ovary, Receptors, Androgen, Receptors, Estrogen, Transcriptional Activation, Estrogen Receptor alpha, Estrogen Receptor beta

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Differential expression of estrogen receptor-α and -β and androgen receptor in the ovaries of marmosets and humans

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