The DOI matches its Crossref record.
Oxidative and reductive metabolism by cytochrome P450 2E1
Abstract
We are constantly exposed to many potentially toxic chemicals. Most require metabolic activation to species responsible for cell injury. Although cytochrome P450 2E1 is only one of many different forms of cytochrome P450 that catalyze these reactions, it has an important role in human health as a result of being readily induced by acute and chronic alcohol ingestion. The enzyme efficiently catalyzes the low K m metabolism of compounds commonly used as solvents in industry and at home as well as components found in cigarette smoke, many of which are established carcinogens and hepatotoxins. As a result, there is the potential for increased risk to low level exposure to such chemicals while cytochrome P450 2E1 is induced. Many substrates have been identified for cytochrome P450 2E1. Of the 52 substrates for the enzyme identified in this review, the demethylation of N,N ‐dimethylnitrosamine and the hydroxylation of p ‐nitrophenol and chlorzoxazone are the most effective for monitoring the level of this enzyme. In addition to oxidative reactions, cytochrome P450 2E1 is also an efficient catalyst of reductive reactions. CCl 4 ‐induced hepatotoxicity is one of the best‐documented cases for the participation of cytochrome P450 2E1 in a toxicologically important reductive reaction. The reduction of oxygen to superoxide and peroxide are also important reductive reactions of the enzyme and could be important in lipid peroxidation. However, the role of this reaction in vivo remains controversial.—Koop, D. R. Oxidative and reductive metabolism by cytochrome P450 2E1. FASEB J. 6: 724‐730; 1992.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
The Free Radical Theory of Aging Matures
BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879
Cederbaum, A. I. (2012) · Clinics in Liver Disease · doi:10.1016/j.cld.2012.08.002 · Cited by 1,145
Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis
Lieber, C. S. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.07.008 · Cited by 699
Association of Acetaminophen Hepatotoxicity With Fasting and Ethanol Use
Whitcomb, D. C. (1994) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1994.03520230055038 · Cited by 470
Gender-related differences in pharmacokinetics and their clinical significance
Tanaka, E. (1999) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1046/j.1365-2710.1999.00246.x · Cited by 281
Lieber, C. S. (2005) · Clinics in Liver Disease · doi:10.1016/j.cld.2004.10.005 · Cited by 274
Ethanol Increases Cytochrome P4502E1 and Induces Oxidative Stress in Astrocytes
Montoliu, C., Sancho‐Tello, M., Azorin, I., Burgal, M., Vallés, S., Renau‐Piqueras, J., & Guerri, C. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65062561.x · Cited by 218
Sex-specific differences in CYP450 isoforms in humans
Scandlyn, M. J., Stuart, E. C., & Rosengren, R. J. (2008) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.4.4.413 · Cited by 199
Song, B. J., & Cederbaum, A. I. (1996) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01764.x · Cited by 148
Inactivation of oxidized and S-nitrosylated mitochondrial proteins in alcoholic fatty liver of rats
Moon, K.-H., Hood, B. L., Kim, B.-J., Hardwick, J. P., Conrads, T. P., Veenstra, T. D., & Song, B. J. (2006) · Hepatology · doi:10.1002/hep.21372 · Cited by 120
Lefebvre, P., Lalloyer, F., Baugé, E., Pawlak, M., Gheeraert, C., Dehondt, H., Vanhoutte, J., Woitrain, E., Hennuyer, N., Mazuy, C., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.92264 · Cited by 117
Kim, B., Hood, B. L., Aragon, R. A., Hardwick, J. P., Conrads, T. P., Veenstra, T. D., & Song, B. J. (2006) · PROTEOMICS · doi:10.1002/pmic.200500447 · Cited by 83
Abdelmegeed, M. A., Moon, K.-H., Chen, C., Gonzalez, F. J., & Song, B.-J. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.07.016 · Cited by 81
Suh, S., Hood, B. L., Kim, B., Conrads, T. P., Veenstra, T. D., & Song, B. J. (2004) · PROTEOMICS · doi:10.1002/pmic.200400971 · Cited by 76
Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications
Song, B.-J., Abdelmegeed, M. A., Yoo, S.-H., Kim, B.-J., Jo, S. A., Jo, I., & Moon, K.-H. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.05.013 · Cited by 73
Nrf2 and Antioxidant Defense Against CYP2E1 Toxicity
Cederbaum, A. I. (2013) · Subcellular Biochemistry · doi:10.1007/978-94-007-5881-0_2 · Cited by 47
Moon, K.-H., Lee, Y.-M., & Song, B.-J. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.11.008 · Cited by 37
Characterization of a primary hepatocyte culture system for toxicological studies
Zurlo, J., & Arterburn, L. M. (1996) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/bf02722948 · Cited by 35
Metadata
- Authors
- Koop, D. R.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1992-01
- Volume
- 6
- Issue
- 2
- Pages
- 724-730
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2138145189
- Cited by
- 560
- References
- 0
- FWCI
- 23.24
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
