Ethanol‐Inducible Cytochrome P450 (CYP2E1): Biochemistry, Molecular Biology and Clinical Relevance: 1996 Update

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Genetic Polymorphisms in the 5′-Flanking Region Change Transcriptional Regulation of the Human Cytochrome P450IIE1 Gene1

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Role of CYP2E1 in the Hepatotoxicity of Acetaminophen

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Ethanol Oxidation by Hepatic Microsomes: Adaptive Increase after Ethanol Feeding

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Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.

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Induction of Rat Hepatic N-Nitrosodimethylamine Demethylase by Acetone Is Due to Protein Stabilization

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Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol

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Ethanol Induces CYP2E1 by Protein Stabilization

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Markedly Enhanced Cytochrome P450 2E1 Induction and Lipid Peroxidation Is Associated with Severe Liver Injury in Fish Oil—Ethanol‐Fed Rats

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Identification of ethanol-inducible P-450 isozyme 3a as the acetone and acetol monooxygenase of rabbit microsomes.

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Vitamin E Dietary Supplementation Protects Against Carbon Tetrachloride—Induced Chronic Liver Damage and Cirrhosis

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Ethanol-inducible cytochrome P4502E1: Genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liver disease

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Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver

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Formation of 19(S)-, 19(R)-, and 18(R)-hydroxyeicosatetraenoic acids by alcohol-inducible cytochrome P450 2E1

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Multiple mechanisms in the regulation of ethanol‐inducible cytochrome P450IIE1

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Human Cytochrome P450 2E1 Is a Major Autoantigen Associated with Halothane Hepatitis

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Hydrogen peroxide formation and stoichiometry of hydroxylation reactions catalyzed by highly purified liver microsomal cytochrome P-450

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Fish Oil, Alcohol, and Liver Pathology: Role of Cytochrome P450 2E1

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Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver

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Ligand-dependent maintenance of ethanol-inducible cytochrome P-450 in primary rat hepatocyte cell cultures

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Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis.

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Reductive release of iron from ferritin by cation free radicals of paraquat and other bipyridyls.

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Introduction: Role of lipid peroxidation and oxidative stress in alcohol toxicity

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Mitochondrial glutathione depletion in alcoholic liver disease

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Role of cytochrome P4502E1 in alcoholic liver disease pathogenesis

Morimoto, M. S. S., Hagbjörk, A.-L., Nanji, A. A., Ingelman‐Sundberg, M., Lindros, K. O., Fu, P. C., Albano, E., & French, S. W. (1993) · Alcohol · doi:10.1016/0741-8329(93)90065-v · Cited by 152 · see citing works

Degradation of cytochrome P450 2E1: Selective loss after labilization of the enzyme

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Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects

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Detection of a protein-acetaldehyde adduct in the liver of rats fed alcohol chronically.

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Cytochrome P450 CYP 2E1 induction during chronic alcohol exposure occurs by a two-step mechanism associated with blood alcohol concentrations in rats.

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Effect of Ethanol on Cytochrome P450 2E1 (CYP2E1), Lipid Peroxidation, and Serum Protein Adduct Formation in Relation to Liver Pathology Pathogenesis

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Formation of acetaldehyde adducts with ethanol-inducible P450IIE1 in vivo

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Increased NADPH- and NADH-Dependent Production of Superoxide and Hydroxyl Radical by Microsomes after Chronic Ethanol Treatment

Rashba-Step, J., TURRO, N. J., & Cederbaum, A. I. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1054 · Cited by 133 · see citing works

The human CYP2E1 gene and lung cancer: DraI and RsaI restriction fragment length polymorphisms in a Finish study population

Hirvonen, A., Husgafvel‐Pursiainen, K., Anttila, S. L., Karjalainen, A., & Vainio, H. (1993) · Carcinogenesis · doi:10.1093/carcin/14.1.85 · Cited by 125 · see citing works

Alcohol‐Metabolizing Enzyme Polymorphisms and Alcoholism in Japan

Maezawa, Y., Yamauchi, M., Toda, G., Suzuki, H., & Sakurai, S. (1995) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb00972.x · Cited by 125 · see citing works

Hormone- and substrate-regulated intracellular degradation of cytochrome P450 (2E1) involving MgATP-activated rapid proteolysis in the endoplasmic reticulum membranes.

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Induction of CYP2E1 in Liver, Kidney, Brain and Intestine During Chronic Ethanol Administration and Withdrawal: Evidence That CYP2E1 Possesses a Rapid Phase Half-Life of 6 Hours or Less

Roberts, B. J., Shoaf, S. E., Jeong, K. S., & Song, B. J. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2774 · Cited by 116 · see citing works

Detection of antibodies against proteins modified by hydroxyethyl free radicals in patients with alcoholic cirrhosis

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Cytochrome P4502E1 hydroxyethyl radical adducts as the major antigen in autoantibody formation among alcoholics

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Regulation of Hepatic Microsomal Cytochrome P450IIE1 Level by Dietary Lipids and Carbohydrates in Rats

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Induction of Cytochrome P450 2E1 during Chronic Ethanol Exposure Occurs via Transcription of the Cyp 2E1 Gene When Blood Alcohol Concentrations Are High

Badger, T. M., Huang, J., Ronis, M. J. J., et al. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1117 · Cited by 109 · see citing works

Plasma levels of a novel noncyclooxygenase-derived prostanoid (8-isoprostane) correlate with severity of liver injury in experimental alcoholic liver disease.

Nanji, A. A., Khwaja, S., Tahan, S. R., et al. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38874-9 · Cited by 107 · see citing works

Restriction fragment length polymorphism of the human CYP 2E1 (cytochrome P450IIE1) gene and susceptibility to lung cancer

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Expression, induction, and catalytic activity of the ethanol-inducible cytochrome P450 (CYP2E1) in human fetal liver and hepatocytes.

Carpenter, S. P., Lasker, J. M., & Raucy, J. L. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08707-3 · Cited by 104 · see citing works

Dietary saturated fatty acids: A novel treatment for alcoholic liver disease

Nanji, A. A., Sadrzadeh, S. M. H., Yang, E. K., Fogt, F., Meydani, M., & Dannenberg, A. J. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90344-5 · Cited by 102 · see citing works

In Vivo Induction of Hepatic P4502E1 by Ethanol: Role of Increased Enzyme Synthesis

Tsutsumi, M., Lasker, J. M., Takahashi, T., & LIEBER, C. S. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1341 · Cited by 98 · see citing works

Role of the Liver-Enriched Transcription Factor HNF-1α in Expression of the CYP2E1 Gene

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Hydroxyl-radical production and ethanol oxidation by liver microsomes isolated from ethanol-treated rats

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Humoral immune response to acetaldehyde adducts in alcoholic patients.

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Rapid changes in cytochrome P4502E1 (CYP2E1) activity and other P450 isozymes following ethanol withdrawal in rats

Roberts, B. J., Shoaf, S. E., & Song, B. J. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00098-k · Cited by 82 · see citing works

Acetone‐regulated synthesis and degradation of cytochrome P4502E2 and cytochrome P4502B1 in rat liver

Ronis, M. J. J., Johansson, I., Hultenby, K. R., Lagercrantz, J., Glaumann, H., & Ingelman‐Sundberg, M. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb16026.x · Cited by 81 · see citing works

Drug-Induced Allergic Hepatitis

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Polyenylphosphatidylcholine attenuates non-alcoholic hepatic fibrosis and accelerates its regression

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Insulin down-regulates cytochrome P450 2B and 2E expression at the post-transcriptional level in the rat hepatoma cell line.

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Ethanol-derived immunoreactive species formed by free radical mechanisms.

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Medium chain triglycerides and vitamin E reduce the severity of established experimental alcoholic liver disease.

Nanji, A. A., Yang, E. K., Fogt, F., et al. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13125-x · Cited by 76 · see citing works

Pretranslational activation of cytochrome P450IIE during ketosis induced by a high fat diet.

Yun, Y., Casazza, J. P., Sohn, D. H., et al. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08939-4 · Cited by 76 · see citing works

Chlormethiazole as an efficient inhibitor of cytochrome P450 2E1 expression in rat liver.

Hu, Y., Мишин, В. М., Johansson, I., et al. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38876-2 · Cited by 73 · see citing works

Presence of functionally active cytochrome P-450IIE1 in the plasma membrane of rat hepatocytes

Wu, D., & Cederbaum, A. I. (1992) · Hepatology · doi:10.1002/hep.1840150326 · Cited by 69 · see citing works

CYP-2E1 Inhibitors Partially Ameliorate the Changes in Hepatic Fatty Acid Composition Induced in Rats by Chronic Administration of Ethanol and a High Fat Diet

Morimoto, M., Reitz, R. C., Morin, R. J., et al. (1995) · Journal of Nutrition · doi:10.1093/jn/125.12.2953 · Cited by 67 · see citing works

Evidence That Cytochrome-P450 2E1 Is Involved in the (ω-1)-Hydroxylation of Lauric Acid in Rat Liver Microsomes

Amet, Y., Berthou, F., Goasduff, T., Salaün, J., Lebreton, L., & Menez, J. F. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2305 · Cited by 67 · see citing works

Polymorphism at the P450IIE1 Locus Is Not Associated with Alcoholic Liver Disease in Caucasian Men

Carr, L. G., Hartleroad, J. Y., Liang, Y., Mendenhall, C. L., Moritz, T., & Thomasson, H. R. (1995) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb01489.x · Cited by 66 · see citing works

Additive effects of inducers and fasting on acetaminophen hepatotoxicity

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Expression of CYP2E1 during human fetal development: methylation of the CYP2E1 gene in human fetal and adult liver samples

Jones, S., Boobis, A. R., Moore, G. E., & Stanier, P. (1992) · Biochemical Pharmacology · doi:10.1016/0006-2952(92)90726-y · Cited by 63 · see citing works

Degradation of rat liver cytochromes P450 3A after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: Characterization of the proteolytic system

Correia, M. A., Davoll, S. H., Wrighton, S. A., et al. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90666-k · Cited by 63 · see citing works

Inactivation and degradation of human cytochrome P4502E1 by CCl4 in a transfected HepG2 cell line.

Dai, Y., & Cederbaum, A. I. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12225-8 · Cited by 63 · see citing works

Cytochrome P4502B follows a vesicular route to the plasma membrane in cultured rat hepatocytes

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cDNA and derived amino acid sequence of ethanol-inducible rabbit liver cytochrome P-450 isozyme 3a (P-450ALC).

Khani, S. C., Zaphiropoulos, P. G., Fujita, V. S., et al. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.3.638 · Cited by 62 · see citing works

Changes in Microsomal Phospholipases and Arachidonic Acid in Experimental Alcoholic Liver Injury: Relationship to Cytochrome P‐450 2E1 Induction and Conjugated Diene Formation

Nanji, A. A., Zhao, S., Lamb, R. G., et al. (1993) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1993.tb00806.x · Cited by 58 · see citing works

Enzyme-Specific Transport of Rat Liver Cytochrome P450 to the Golgi Apparatus

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Lipid hydroperoxide induced mitochondrial dysfunction following acute ethanol intoxication in rats

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Effects of In Utero Administration of Alcohol on Glutathione Levels in Brain and Liver

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A Structural Assignment for a Stable Acetaldehyde-Lysine Adduct

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Purification and properties of a cytochrome P450 arachidonic acid epoxygenase from rabbit renal cortex.

Laethem, R. M., Laethem, C. L., & Koop, D. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42801-3 · Cited by 49 · see citing works

ETHANOL INDUCES THE PRODUCTION OF ANTIBODIES TO ACETALDEHYDE-MODIFIED EPITOPES IN RATS

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Reductive beta-scission of the hydroperoxides of fatty acids and xenobiotics: role of alcohol-inducible cytochrome P-450.

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DNA strand cleavage as a sensitive assay for the production of hydroxyl radicals by microsomes: role of cytochrome P4502E1 in the increased activity after ethanol treatment

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Characterization of cytochrome P450 2E1 induction in a rat hepatoma FGC-4 cell model by ethanol

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Characterization of the cytochrome P-450 monooxygenase system of hamster liver microsomes

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