The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Obesity, diabetes, and neoplasia in yellow A vy /‐ mice: ectopic expression of the agouti gene
Abstract
The viable yellow A vy mutation results in a mottled yellow mouse that is obese, slightly larger than its nonyellow sibs, and more susceptible to tumor formation in those tissues sensitized by the strain genome. The mutation exhibits variable expressivity resulting in a continuum of coat color phenotypes, from clear yellow to pseudoagouti. The mouse agouti protein is a paracrine signaling molecule that induces hair follicle melanocytes to switch from the synthesis of black pigment to yellow pigment. Molecular cloning studies indicate that the obesity and growth effects of the A vy mutation result from ectopic expression of the normal agouti gene product. This review seeks to summarize the current state of knowledge regarding the obesity, stimulation of somatic growth, and enhancement of tumor formation caused by the A vy mutation, and to interpret these pleiotropic effects in terms of the normal function of the agouti protein.—Yen, T. T., Gill, A. M., Frigeri, L. G., Barsh, G. S., and Wolff, G. L. Obesity, diabetes, and neoplasia in yellow A vy /‐ mice: ectopic expression of the agouti gene. FASEB J. 8: 479‐488; 1994.
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Cites
The cloning of a family of genes that encode the melanocortin receptors
Mountjoy, K. G., Robbins, L. S., Mortrud, M. T., & Cone, R. D. (1992) · Science · doi:10.1126/science.1325670 · Cited by 1,635
Effects of parabiosis of obese with diabetes and normal mice.
Coleman, D. L. (1973) · Diabetologia · doi:10.1007/bf01221857 · Cited by 729
Impaired Glucose Tolerance as a Disorder of Insulin Action
Lillioja, S., Mott, D. M., Howard, B. V., Bennett, P. H., Yki-Järvinen, H., Freymond, D., Nyomba, B. L., Zurlo, F., Swinburn, B., & Bogardus, C. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805123181901 · Cited by 578
INFLUENCE OF MATERNAL PHENOTYPE ON METABOLIC DIFFERENTIATION OF AGOUTI LOCUS MUTANTS IN THE MOUSE
Wolff, G. L. (1978) · Genetics · doi:10.1093/genetics/88.3.529 · Cited by 95
Self-citation
Cited by
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030
Transposable elements: targets for early nutritional effects on epigenetic gene regulation
Waterland, R. A., & Jirtle, R. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5293-5300.2003 · Cited by 2,019
Epigenetics and the environment: emerging patterns and implications
Feil, R., & Fraga, M. F. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3142 · Cited by 1,929
Anatomy and regulation of the central melanocortin system
Cone, R. D. (2005) · Nature Neuroscience · doi:10.1038/nn1455 · Cited by 1,583
Metadata
- Authors
- Yen, T. T., Gill, A. M., Frigeri, L. G., Barsh, G. S., & Wolff, G. L.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1994-05
- Volume
- 8
- Issue
- 8
- Pages
- 479-488
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2133824155
- Cited by
- 308
- References
- 4
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Obesity, diabetes, and neoplasia in yellow A vy /‐ mice: ectopic expression of the agouti gene. https://app.cochat.ai/papers/10.1096/fasebj.8.8.8181666
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- Yen, T. T., Gill, A. M., Frigeri, L. G., Barsh, G. S., & Wolff, G. L. (1994). Obesity, diabetes, and neoplasia in yellow A vy /‐ mice: ectopic expression of the agouti gene. The FASEB Journal. https://doi.org/10.1096/fasebj.8.8.8181666
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
