Cited by 118Mitochondrial Function and PathologyAdipose Tissue and MetabolismThyroid Disorders and Treatments

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Triiodothyronine‐mediated upregulation of UCP2 and UCP3 mRNA expression in human skeletal muscle without coordinated induction of mitochondrial respiratory chain genes

Barbe, Pierre, Larrouy, Dominique, Boulanger, Catherine, Chevillotte, Emmanuel, Viguerie, Nathalie, Thalamas, Claire, Oliva Trastoy, Manel, Roques, Marina, Vidal, Hubert, Langin, Dominique·2001·The FASEB Journal

DOI 10.1096/fj.00-0502fje

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Abstract

Triiodothyronine (T3) increases mitochondrial respiration and promotes the uncoupling between oxygen consumption and ATP synthesis. T3 effect is mediated partly through transcriptional control of genes encoding mitochondrial proteins. We determined the effect of T3 on mRNA levels of uncoupling proteins (UCP) and proteins involved in the biogenesis of the respiratory chain in human skeletal muscle and on UCP2 mRNA expression in adipose tissue. Ten young, healthy males received 75 to 100 µg of T3 per day for 14 days. The increase in plasma‐free T3 levels was associated with an increase of resting metabolic rate and a decrease of respiratory quotient. In skeletal muscle, treatment with T3 induced a twofold increase of both UCP2 and UCP3 mRNA levels (p < 0.01). The mRNA levels of cytochrome c oxidase subunits 2 and 4, nuclear respiratory factor 1, mitochondrial transcription factor A, and the co‐activator PGC1 did not change during the treatment. In adipose tissue, UCP2 mRNA levels increased threefold. The direct effect of T3 on skeletal muscle and adipose tissue UCP2 and UCP3 mRNA expression was demonstrated in vitro in human primary cultures. Our data show that T3 induces UCP2 and UCP3 mRNA expression in humans. In skeletal muscle, UCP regulation by T3 is not associated with the transcriptional regulation of respiratory chain proteins.

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Authors: Barbe, P., Larrouy, D., Boulanger, C., Chevillotte, E., Viguerie, N., Thalamas, C., Oliva Trastoy, M., Roques, M., Vidal, H., & Langin, D.
Affiliations: Université Toulouse III - Paul Sabatier (FR)
Inserm (FR)
Hôpital Purpan (FR)
INSERM Unit 317 Institut Louis Bugnard Université Paul Sabatier Hôpital Rangueil Toulouse France
ORCID: Barbe, Pierre
Larrouy, Dominique
Viguerie, Nathalie
Thalamas, Claire
Vidal, Hubert
Langin, Dominique
Venue: The FASEB Journal
Publisher: Wiley
Published: 2000-11-09
Volume: 15
Issue: 1
Pages: 13-15
ISSN: 0892-6638 (ISSN-L)
1530-6860
DOI: 10.1096/fj.00-0502fje
OpenAlex: W2159785275
Cited by: 118
References: 49
Citations by year: 2026: 2 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 7 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 7
FWCI: 2.65
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The FASEB Journal (publishedVersion)
PubMed (publishedVersion)
Funders: Institut National de la Santé et de la Recherche Médicale (4P007E, 4P020D)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Keywords: triiodothyronine, uncoupling proteins, UCP2, UCP3, skeletal muscle, adipose tissue, mitochondrial uncoupling, mitochondrial transcription factors, PGC-1, resting metabolic rate, respiratory quotient
MeSH terms: Uncoupling Protein 2, Uncoupling Protein 3, Adipose Tissue, Carrier Proteins, Cells, Cultured, DNA, Mitochondrial, Electron Transport, Humans, Ion Channels, Male, Mitochondria, Models, Biological, Models, Genetic, Proteins, RNA, Messenger, Triiodothyronine, Uncoupling Agents, Up-Regulation, Muscle, Skeletal, Mitochondrial Proteins, Membrane Transport Proteins

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Triiodothyronine‐mediated upregulation of UCP2 and UCP3 mRNA expression in human skeletal muscle without coordinated induction of mitochondrial respiratory chain genes

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