The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Cell migration through defined, synthetic extracellular matrix analogues
Abstract
We have developed synthetic hydrogel extracellular matrix (ECM) analogues that can be used to study mechanisms involved in cell migration, such as receptor‐ligand interactions and proteolysis. The biomimetic hydrogels consist of bioinert polyethylene glycol diacrylate derivatives with proteolytically degradable peptide sequences included in the backbone of the polymer and adhesive peptide sequences grafted to the network. Hydrogels have been developed that degrade as cells secrete proteolytic enzymes. Adhesive peptide sequences grafted to the hydrogel provide ligands that can interact with receptors on the cell surface to mediate adhesion and spreading. In this study, we have characterized the effects of adhesive ligand density on fibroblast migration through collagenase‐degradable and plasmin‐degradable hydrogels and on smooth muscle cell migration through elastase‐degradable hydrogels. In all three cases, we found that cell migration has a biphasic dependence on adhesion ligand concentration, with optimal migration at intermediate ligand levels. Furthermore, both adhesive and proteolytically degradable sequences were required for cell migration to occur. These synthetic ECM analogues may be useful for 3‐D mechanistic studies of many aspects of cell migration
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Cites
Cell Migration: A Physically Integrated Molecular Process
Lauffenburger, D. A., & Horwitz, A. F. (1996) · Cell · doi:10.1016/s0092-8674(00)81280-5 · Cited by 3,915
Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness
Palecek, S. P., Loftus, J. C., Ginsberg, M. H., Lauffenburger, D. A., & Horwitz, A. F. (1997) · Nature · doi:10.1038/385537a0 · Cited by 1,427
Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing
Hern, D. L., & Hubbell, J. A. (1998) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199802)39:2<266::aid-jbm14>3.0.co;2-b · Cited by 904
Mann, B. K., Gobin, A. S., Tsai, A. T., Schmedlen, R. H., & West, J. L. (2001) · Biomaterials · doi:10.1016/s0142-9612(01)00051-5 · Cited by 704
Self-citationThe biology of cell locomotion within three-dimensional extracellular matrix
Friedl, P., & Br�cker, E.-B. (2000) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s000180050498 · Cited by 656
Polymeric Biomaterials with Degradation Sites for Proteases Involved in Cell Migration
West, J. L., & Hubbell, J. A. (1999) · Macromolecules · doi:10.1021/ma981296k · Cited by 625
Self-citationDiMilla, P., Stone, J., Quinn, J., Albelda, S., & Lauffenburger, D. (1993) · The Journal of cell biology · doi:10.1083/jcb.122.3.729 · Cited by 600
Huttenlocher, A. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80112-x · Cited by 513
Tethered-TGF-β increases extracellular matrix production of vascular smooth muscle cells
Mann, B. K., Schmedlen, R. H., & West, J. L. (2001) · Biomaterials · doi:10.1016/s0142-9612(00)00196-4 · Cited by 449
Self-citationElbert, D. L., & Hubbell, J. A. (2001) · Biomacromolecules · doi:10.1021/bm0056299 · Cited by 409
Cited by
Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551
Hydrogels as extracellular matrix mimics for 3D cell culture
Tibbitt, M. W., & Anseth, K. S. (2009) · Biotechnology and Bioengineering · doi:10.1002/bit.22361 · Cited by 2,727
RGD modified polymers: biomaterials for stimulated cell adhesion and beyond
Hersel, U., Dahmen, C., & Kessler, H. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00343-0 · Cited by 2,582
Cell-laden microengineered gelatin methacrylate hydrogels
Nichol, J. W., Koshy, S. T., Bae, H., Hwang, C. M., Yamanlar, S., & Khademhosseini, A. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.064 · Cited by 2,377
Lutolf, M. P., Lauer-Fields, J. L., Schmoekel, H. G., Metters, A. T., Weber, F. E., Fields, G. B., & Hubbell, J. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0737381100 · Cited by 1,508
Metadata
- Authors
- Gobin, A. S., & West, J. L.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2002-03-26
- Volume
- 16
- Issue
- 7
- Pages
- 751-753
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1562490776
- Cited by
- 257
- References
- 23
- FWCI
- 5.26
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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