The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.
The role of tumor lymphangiogenesis in metastatic spread
Abstract
The high mortality rates associated with cancer can be attributed to the metastatic spread of tumor cells from the site of their origin. Tumor cells invade either the blood or lymphatic vessels to access the general circulation and then establish themselves in other tissues. Clinicopathological data suggest that the lymphatics are an initial route for the spread of solid tumors. Detection of sentinel lymph nodes by biopsy provides significant information for staging and design‐ing therapeutic regimens. The role of angiogenesis in facilitating the growth of solid tumors has been well established, but the presence of lymphatic vessels and the relevance of lymphangiogenesis to tumor spread are less clear. Recently, the molecular pathway that signals for lymphangiogenesis and relatively specific markers for lymphatic endothelium have been described allowing analyses of tumor lymphangiogenesis to be performed in animal models. These studies demonstrate that tumor lymphangiogenesis is a major component of the metastatic process and implicate members of the VEGF family of growth factors as key mediators of lymphangiogenesis in both normal biology and tumors.—Stacker, S. A., Baldwin, M. E., Achen, M. G. The role of tumor lymphangiogenesis in metastatic spread. FASEB J. 16, 922–934 (2002)
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Cites
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Cited by
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VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells
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Transcriptional Control of Endothelial Cell Development
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“In addition, vascularization of solid tumors is essential for their growth and eventual metastasis (Carmeliet and Jain, 2000; Stacker et al., 2002).”
BackgroundCombinatorial Regulation of Endothelial Gene Expression by Ets and Forkhead Transcription Factors
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Metadata
- Authors
- STACKER, S. A., BALDWIN, M. E., & ACHEN, M. G.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2002-07
- Volume
- 16
- Issue
- 9
- Pages
- 922-934
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1996976458
- Cited by
- 296
- References
- 121
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
