The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Altered angiogenesis and survival in human tumor‐derived endothelial cells
Abstract
Knowledge on the functional properties of tumor‐derived endothelial cells (TEC) can be relevant for the development of antiangiogenic therapeutic strategies. In the present study, we obtained and characterized endothelial cell lines from human renal carcinomas. TEC did not undergo senescence and showed constant expression of markers of endothelial activation and angiogenesis. In vitro, TEC, in contrast to normal endothelial cells, were resistant to apoptosis, proadhesive for renal carcinoma cells, and able to grow and organize in the absence of serum in persistent capillary‐like structures. In vivo, TEC were able to grow in immunodeficient mice and to form vascular structures connected with the circulation. At a molecular level, gene array analysis showed an increased expression of genes involved in survival and cell adhesion compared with expression in normal microvascular endothelial cells. Moreover, expression of angiopoietin‐1 and vascular endothelial growth factor (VEGF)‐D and the Akt survival pathway were up‐regulated. Inhibition of interaction of VEGFR‐2 or VEGFR‐3 with VEGF‐D but not of Tie‐2‐angiopoietin‐1 interaction with soluble receptors abrogated Akt activation and survival of TEC. These results indicate that at least some of the TEC within a tumor display abnormal characteristics in terms of survival and angiogenic properties and also indicate the presence of a functional autocrine pathway related to VEGF‐D.
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Cites
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VEGF-D promotes the metastatic spread of tumor cells via the lymphatics
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Cited by
Grange, C., Tapparo, M., Collino, F., Vitillo, L., Damasco, C., Deregibus, M. C., Tetta, C., Bussolati, B., & Camussi, G. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0241 · Cited by 851
Self-citationEndothelial Cell Heterogeneity
Aird, W. C. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006429 · Cited by 731
Eelen, G., de Zeeuw, P., Treps, L., Harjes, U., Wong, B. W., & Carmeliet, P. (2018) · Physiological Reviews · doi:10.1152/physrev.00001.2017 · Cited by 572
Tumor-Associated Endothelial Cells with Cytogenetic Abnormalities
Hida, K., Hida, Y., Amin, D. N., Flint, A. F., Panigrahy, D., Morton, C. C., & Klagsbrun, M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1567 · Cited by 470
Dudley, A. C. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006536 · Cited by 424
Metadata
- Authors
- Bussolati, B., Deambrosis, I., Russo, S., Deregibus, M. C., & Camussi, G.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2003-04-22
- Volume
- 17
- Issue
- 9
- Pages
- 1159-1161
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2133653109
- Cited by
- 288
- References
- 41
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- closed
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