The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic Niche
Open accessAbstract
Recent studies suggest that tumor-derived microvesicles (MV) act as a vehicle for exchange of genetic information between tumor and stromal cells, engendering a favorable microenvironment for cancer development. Within the tumor mass, all cell types may contribute to MV shedding, but specific contributions to tumor progression have yet to be established. Here we report that a subset of tumor-initiating cells expressing the mesenchymal stem cell marker CD105 in human renal cell carcinoma releases MVs that trigger angiogenesis and promote the formation of a premetastatic niche. MVs derived only from CD105-positive cancer stem cells conferred an activated angiogenic phenotype to normal human endothelial cells, stimulating their growth and vessel formation after in vivo implantation in immunocompromised severe combined immunodeficient (SCID) mice. Furthermore, treating SCID mice with MVs shed from CD105-positive cells greatly enhanced lung metastases induced by i.v. injection of renal carcinoma cells. Molecular characterization of CD105-positive MVs defines a set of proangiogenic mRNAs and microRNAs implicated in tumor progression and metastases. Our results define a specific source of cancer stem cell–derived MVs that contribute to triggering the angiogenic switch and coordinating metastatic diffusion during tumor progression. Cancer Res; 71(15); 5346–56. ©2011 AACR.
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1 retracted
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Stem cells, cancer, and cancer stem cells
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Shedding microvesicles: artefacts no more
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Cited by
Regulation of immune responses by extracellular vesicles
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Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis
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Targeting cancer stem cell pathways for cancer therapy
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Pre-metastatic niches: organ-specific homes for metastases
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Extracellular vesicles in cancer — implications for future improvements in cancer care
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Metadata
- Authors
- Grange, C., Tapparo, M., Collino, F., Vitillo, L., Damasco, C., Deregibus, M. C., Tetta, C., Bussolati, B., & Camussi, G.
- Venue
- Cancer Research
- Published
- 2011-07-28
- Volume
- 71
- Issue
- 15
- Pages
- 5346-5356
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2110576880
- Cited by
- 851
- References
- 48
- FWCI
- 20.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Grange, C., Tapparo, M., Collino, F., Vitillo, L., Damasco, C., Deregibus, M. C., Tetta, C., Bussolati, B., & Camussi, G. (2011). Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic Niche. Cancer Research. https://doi.org/10.1158/0008-5472.can-11-0241
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